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公开(公告)号：US20110135602A1
公开(公告)日：2011-06-09
申请号：US12735882
申请日：2008-12-02
摘要： The invention relates to suppressor of the endogenous human interferon-gamma (hlFN-γ) applicable in treatment of diseases associated with impaired activity of endogenous hlFN-γ, especially autoimmune diseases and for prevention of graft arteriosclerosis and rejection of organs in allograft transplanted patients. It is based on inactive analogues of the hlFN-γ with pre-served affinity to the hlFN-γ receptor, genetically modified in the domain responsible for triggering the signal transduction pathway.
摘要翻译： 本发明涉及内源性人干扰素-γ（hlFN-γ）的抑制剂，其适用于治疗与内源性hILF-γ的活性受损，特别是自身免疫性疾病相关的疾病，以及用于预防移植物移植患者的移植物动脉硬化和器官排斥。 它基于具有对hILF-γ受体的预先亲和力的hILF-γ的无活性类似物，在负责触发信号转导途径的结构域中被遗传修饰。
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公开(公告)号：US20140212383A1
公开(公告)日：2014-07-31
申请号：US14243861
申请日：2014-04-02
IPC分类号： C07K14/57
CPC分类号： C07K14/57 , A61K38/00 , A61K38/217
摘要： The invention relates to suppressors of endogenous human interferon-gamma (INF-γ) applicable in treatment of diseases associated with impaired activity of endogenous IFN-γ. The suppressors of the invention are useful in treating autoimmune diseases and for prevention of graft arteriosclerosis and rejection of organs in allograft transplanted patients. The invention includes inactive analogues or variants of IFN-γ having preserved affinity to the IFN-γ receptor, genetically modified in the domain responsible for triggering the signal transduction pathway.
摘要翻译： 本发明涉及适用于治疗与内源性IFN-γ活性受损有关的疾病的内源性人干扰素-γ（INF-γ）抑制剂。 本发明的抑制剂可用于治疗自体免疫疾病和预防移植物移植患者的移植物动脉硬化和器官排斥。 本发明包括对负责触发信号转导途径的结构域经遗传修饰的IFN-γ受体具有保护亲和性的无活性类似物或变体。
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公开(公告)号：US07973133B2
公开(公告)日：2011-07-05
申请号：US11886853
申请日：2005-10-05
CPC分类号： C07K14/57 , A61K38/00 , C07K14/56 , C07K2319/00
摘要： The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity to the hIFN-ϝ receptor. The derivatives represent genetically modified variants of hIFN-ϝ where the C-terminal part of the molecule is either deleted or replaced with a polypeptide sequence of another human protein and a recombinant hIFN-ϝ inactivated by physical or chemical methods.
摘要翻译： 本发明涉及自身免疫性疾病，特别是多发性硬化症中的内源性人干扰素-γ（hIFN-γ）抑制剂。 更准确地说，本发明涉及hIFN-γ的灭活蛋白衍生物; 与hIFN-gamma保持亲和力; 受体。 衍生物表示hIFN-γ的遗传修饰变体，其中分子的C末端部分被缺失或被另一种人类蛋白质和重组hIFN-γ的多肽序列替代; 通过物理或化学方法灭活。
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公开(公告)号：US20090208452A1
公开(公告)日：2009-08-20
申请号：US11886853
申请日：2005-10-05
CPC分类号： C07K14/57 , A61K38/00 , C07K14/56 , C07K2319/00
摘要： The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity to the hIFN-ϝ receptor. The derivatives represent genetically modified variants of hIFN-ϝ where the C-terminal part of the molecule is either deleted or replaced with a polypeptide sequence of another human protein and a recombinant hIFN-ϝ inactivated by physical or chemical methods.
摘要翻译： 本发明涉及自身免疫性疾病，特别是多发性硬化症中的内源性人干扰素-γ（hIFN-γ）抑制剂。 更准确地说，本发明涉及具有保留的hIFN-γ受体亲和力的hIFN-γ的灭活蛋白衍生物。 衍生物表示hIFN-γ的遗传修饰变体，其中分子的C末端部分被缺失或被另一种人蛋白质的多肽序列替代，并且通过物理或化学方法灭活的重组hIFN-γ。
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公开(公告)号：US20110286966A1
公开(公告)日：2011-11-24
申请号：US13036341
申请日：2011-02-28
CPC分类号： C07K14/57 , A61K38/00 , C07K14/56 , C07K2319/00
摘要： Modified endogenous human interferon-gamma (hIFN-γ), biologically inactive but preserving binding affinity to the hIFN-γ receptor, has applicability in the treatment of autoimmune diseases, especially multiple sclerosis.
摘要翻译： 修饰的内源性人干扰素-γ（hIFN-γ）对hIFN-γ受体具有生物活性但保留的结合亲和力，可用于治疗自身免疫性疾病，特别是多发性硬化症。
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公开(公告)号：US20110218325A1
公开(公告)日：2011-09-08
申请号：US13036386
申请日：2011-02-28
IPC分类号： C07K14/57
CPC分类号： C07K14/57 , A61K38/00 , C07K14/56 , C07K2319/00
摘要： Inactivated protein derivatives of the hIFN-γ that preserve affinity to the hIFN-γ receptor are useful in the treatment of autoimmune diseases, especially multiple sclerosis.
摘要翻译： 保留对hIFN-γ受体亲和力的hIFN-γ的灭活蛋白衍生物可用于治疗自身免疫性疾病，特别是多发性硬化症。
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公开(公告)号：US20100158865A1
公开(公告)日：2010-06-24
申请号：US12656170
申请日：2010-01-20
IPC分类号： A61K38/21
CPC分类号： C07K14/57 , A61K38/00 , C07K14/56 , C07K2319/00
摘要： The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity to the hIFN-ϝ receptor. The derivatives represent genetically modified variants of hIFN-ϝ, where the C-terminal part of the molecule is either deleted or replaced with a polypeptide sequence of another human protein and a recombinant hIFN-ϝ, inactivated by physical or chemical methods.
摘要翻译： 本发明涉及自身免疫性疾病，特别是多发性硬化症中的内源性人干扰素-γ（hIFN-γ）抑制剂。 更准确地说，本发明涉及hIFN-γ的灭活蛋白衍生物; 与hIFN-gamma保持亲和力; 受体。 衍生物代表hIFN-γ的遗传修饰的变体，其中分子的C末端部分被缺失或用另一种人蛋白质的多肽序列和重组hIFN-γ替代，通过物理或化学方法失活。
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公开(公告)号：US20130043807A1
公开(公告)日：2013-02-21
申请号：US13570820
申请日：2012-08-09
申请人： Ammar Burayez , Ivan Ivanov , William A. Hunt , John W. Matthews
发明人： Ammar Burayez , Ivan Ivanov , William A. Hunt , John W. Matthews
IPC分类号： H05B37/02
CPC分类号： H05B41/391 , H05B37/02
摘要： Various techniques are provided for implementing a lighting device variable control using a variable inductor. In various examples, the variable control may be implemented with a plurality of continuous or stepped settings. The variable control may be adjusted by a user-actuated movement of a part of the lighting device, such as the depression of a tail cap or another appropriate physical control to change the inductance of the variable inductor. An oscillating signal may be induced in a variable inductor circuit that includes the variable inductor. The oscillating signal may exhibit characteristics, such as frequency, that change with the inductance of the variable inductor. Such characteristics may be measured to determine a setting of the variable control and which may be used to adjust the brightness or other attributes of the lighting device.
摘要翻译： 提供了各种技术来实现使用可变电感器的照明装置可变控制。 在各种示例中，可以用多个连续或阶梯式设置实现可变控制。 可变控制可以通过照明装置的一部分的用户启动的移动来调节，例如按下尾帽或另一适当的物理控制以改变可变电感器的电感。 可以在包括可变电感器的可变电感器电路中感应振荡信号。 振荡信号可以表现出随着可变电感器的电感而变化的诸如频率的特性。 可以测量这样的特性以确定可变控制的设置，并且其可以用于调节照明装置的亮度或其他属性。
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公开(公告)号：US07880674B2
公开(公告)日：2011-02-01
申请号：US10548087
申请日：2004-03-08
申请人： Ivan Ivanov , Hristo Prodanov , Velislav Panayotov
发明人： Ivan Ivanov , Hristo Prodanov , Velislav Panayotov
IPC分类号： H01Q3/00
CPC分类号： H01Q1/3208 , G01S3/42 , H01Q1/325 , H01Q3/04 , H01Q3/2605 , H01Q3/30
摘要： Tracking system for flat mobile antenna, which includes: sensors for angular velocity (1), which sense the rotation of the antenna around their axes; sensors, sensing the orientation of the antenna according to vertical axis (2); control block (3), which calculates necessary corrections of the direction of antenna beam and which is connected to outputs of sensors (1, 2) and with inputs of driving block (4) and beam control block (5); at least one motor (7), which changes the orientation of the antenna and which is connected to the output of driving block (4) and which drives the antenna panel (8); block for electronic beam steering (5), which is connected to antenna panel (8); power supply block, which converts the voltage from the electrical network of the vehicle into suitable values for providing of power supply of all blocks of the system.
摘要翻译： 用于平板移动天线的跟踪系统，其包括：用于角速度（1）的传感器，其感测天线绕其轴的旋转; 传感器，根据垂直轴（2）感测天线的方向; 控制块（3），其计算天线波束的方向的必要校正，并且连接到传感器（1,2）的输出和驱动块（4）和波束控制块（5）的输入; 至少一个电动机（7），其改变所述天线的方位并连接到所述驱动块（4）的输出并驱动所述天线板（8）; 用于电子束转向（5）的块，其连接到天线面板（8）; 电源块，其将来自车辆电网的电压转换成用于提供系统的所有块的电源的适当值。
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公开(公告)号：US10274845B2
公开(公告)日：2019-04-30
申请号：US13091457
申请日：2011-04-21
申请人： Ivan Ivanov , Taoufik Mbarek , Mathias Huesing , Burkhard Corves
发明人： Ivan Ivanov , Taoufik Mbarek , Mathias Huesing , Burkhard Corves
摘要： An optical module, in particular for microlithography, includes an optical element and a support unit. The optical element has at least one optically utilized area, which defines a rotational axis of symmetry. To support the optical element the support unit has a plurality of more than three support elements. Each of the support elements in the area of a first end is connected with the optical element and in the area of a second end is connected with the support structure. The support unit is designed such that the degree of freedom of rotation of the optical element around the rotational axis of symmetry is restricted, while the position or orientation of the optical element in the other five degrees of freedom is spatially adjustable via the support unit.
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