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    Transdermal electrotransport delivery device including a cathodic reservoir containing a compatible antimicrobial agent
    1.
    发明授权
    Transdermal electrotransport delivery device including a cathodic reservoir containing a compatible antimicrobial agent 有权
    透皮电运输装置包括含有相容的抗微生物剂的阴极储存器

    公开(公告)号：US06181963B2

    公开(公告)日：2001-01-30

    申请号：US09433615

    申请日：1999-11-02

    申请人： Ivan W. Chin ,  Thomas O. Murdock ,  Michel J. N. Cormier

    发明人： Ivan W. Chin ,  Thomas O. Murdock ,  Michel J. N. Cormier

    IPC分类号： A61N130

    CPC分类号： A61N1/30

    摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. The cathode includes a cathodic electrode and a cathodic reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes i) a drug or an electrolyte salt or a mixture thereof and ii) a cetylpyridinium salt in an amount sufficient to inhibit microbial growth in the aqueous medium. The polymeric material is compatible with the cetylpyridinium salt. A process is also provided wherein when electric current flows from the source of electrical power so that the drug is transdermally delivered to the patient by electrotransport from the anodic reservoir, the cetylpyridinium salt is not transdermally delivered to the patient by electrotransport from the cathodic reservoir. A process for preparing a transdermal electrotransport drug delivery device is also provided.

    摘要翻译： 具有电连接到阳极和阴极的阳极，阴极和电源的透皮电运输药物递送装置。 阴极包括阴极电极和阴极储存器，阴极蓄电池包括由聚合物材料和与壳体接触的水性介质构成的壳体。 水性介质包括i）药物或电解质盐或其混合物，和ii）足以抑制水性介质中微生物生长的量的十六烷基吡啶鎓盐。 聚合物材料与十六烷基吡啶鎓盐相容。 还提供了一种方法，其中当电流从电源流出时，使得药物通过从阳极储存器的电转运经皮递送给患者，所以十六烷基吡啶鎓盐不会通过从阴极储存器的电转运经皮递送给患者。 还提供了一种制备透皮电转运药物递送装置的方法。

    Anhydrous drug reservoir for electrolytic transdermal delivery device
    2.
    发明授权
    Anhydrous drug reservoir for electrolytic transdermal delivery device 有权

    公开(公告)号：US06374136B1

    公开(公告)日：2002-04-16

    申请号：US09208808

    申请日：1998-12-09

    申请人： Thomas O. Murdock

    发明人： Thomas O. Murdock

    IPC分类号： A61N130

    CPC分类号： A61N1/0444 ,  A61N1/0448

    摘要： An electrode assembly and a method of forming an anhydrous reservoir layer of an electrode assembly in an electrotransport transdermal agent delivery device are provided. The reservoir layer is adapted to be placed in agent-transmitting relation with a body surface and an electrode in electrical contact with a power source and the reservoir layer. The method includes the steps of dissolving a beneficial agent in a solvent, applying the solvent and dissolved beneficial agent to a surface of a hydrophilic polymer filtration membrane, removing the solvent from the surface of the filtration membrane, and disposing the beneficial agent/filtration membrane within the electrode assembly.

    Electrotransport drug delivery reservoirs containing inert fillers
    3.
    发明授权
    Electrotransport drug delivery reservoirs containing inert fillers 失效
    电子输送含有惰性填料的药物输送储存器

    公开(公告)号：US06246904B1

    公开(公告)日：2001-06-12

    申请号：US08965881

    申请日：1997-11-07

    申请人： Thomas O. Murdock

    发明人： Thomas O. Murdock

    IPC分类号： A61N130

    CPC分类号： A61N1/0448

    摘要： A novel electrotransport drug delivery system (10) and therapeutic agent-containing reservoir (26, 28) for use therein are provided. An inert filler material effective to reduce the quantity of therapeutic agent otherwise present is incorporated in the reservoir (26, 28) along with the therapeutic agent to be delivered via electrotransport. Methods for making the reservoir (26, 28) and drug delivery system (10) are provided as well.

    摘要翻译： 提供了一种用于其中的新型电转运药物递送系统（10）和含治疗剂的储存器（26,28）。 将有效减少另外存在的治疗剂量的惰性填充剂与待经由电转运送的治疗剂一起并入储存器（26,28）中。 还提供了用于制备储存器（26,28）和药物递送系统（10）的方法。

    Enhanced electrotransport of therapeutic agents having polybasic anionic counter ions
    4.
    发明授权
    Enhanced electrotransport of therapeutic agents having polybasic anionic counter ions 失效
    具有多碱性阴离子抗衡离子的治疗剂的增强的电转运

    公开(公告)号：US6004577A

    公开(公告)日：1999-12-21

    申请号：US909678

    申请日：1997-08-12

    申请人： Thomas O. Murdock

    发明人： Thomas O. Murdock

    IPC分类号： A61K9/00 ,  A61K9/70

    CPC分类号： A61K9/0009

    摘要： Improved electrotransport of therapeutic agents which include agent cations and polybasic anionic counterions. Improved electrotransport is obtained by treating the therapeutic agent with a multivalent metal compound of the formula MX where M is a metallic cation having a valency of at least +2 and is reactive with the polybasic anionic counter ion and X is a pH-increasing anion. Reduction in species which compete with the therapeutic agent for electrotranport is obtained.

    摘要翻译： 包括药物阳离子和多元阴离子抗衡离子的治疗剂的改进的电转运。 通过用式MX的多价金属化合物处理治疗剂获得改进的电转运，其中M是至少为+2的化合价的金属阳离子，并且与多元阴离子抗衡离子反应，X是增加pH的阴离子。 获得与电解质治疗剂竞争的物种的减少。

    Polymeric foam reservoirs for an electrotransport delivery device
    5.
    发明授权
    Polymeric foam reservoirs for an electrotransport delivery device 失效
    用于电输送装置的聚合物泡沫储存器

    公开(公告)号：US06650934B2

    公开(公告)日：2003-11-18

    申请号：US08966437

    申请日：1997-11-07

    申请人： Thomas O. Murdock

    发明人： Thomas O. Murdock

    IPC分类号： A61N130

    CPC分类号： A61N1/0448 ,  A61K9/0009

    摘要： A method is provided for preparing a novel therapeutic agent-containing reservoir (26, 28) for use in conjunction with an electrotransport drug delivery system (10). A polymeric matrix is foamed in a selected atmosphere and then cross-linked to form a polymeric closed-cell foam matrix reservoir (26, 28). The method enables relatively smaller quantities of therapeutic agent to be loaded into the electrotransport system (10) and is especially useful for the transdermal delivery of more costly drugs, such as peptides and proteins produced from genetically engineered cell lines, and/or highly potent drugs for which a small dosage is efficacious. Reservoirs (26, 28) prepared according to this method and electrotransport devices (10) containing such reservoirs are also provided.

    摘要翻译： 提供了一种用于制备用于与电运输药物递送系统（10）结合使用的新颖治疗剂储存器（26,28）的方法。 聚合物基体在所选择的气氛中发泡，然后交联以形成聚合物闭孔泡沫基质储存器（26,28）。 该方法能够将相对较少量的治疗剂加载到电转运系统（10）中，并且特别可用于透皮递送更昂贵的药物，例如由遗传工程细胞系产生的肽和蛋白质和/或高效药物 其用量很小。 还提供了根据该方法制备的储存器（26,28）和包含这种储存器的电输送装置（10）。