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公开(公告)号：US06322816B1
公开(公告)日：2001-11-27
申请号：US09463849
申请日：2000-02-01
申请人： Jürgen Zeidler , Jörg Neumann , Bernd Leipold , Jörg Rosenberg , Gunther Berndl , Jörg Breitenbach , Christiane Vollgraf
发明人： Jürgen Zeidler , Jörg Neumann , Bernd Leipold , Jörg Rosenberg , Gunther Berndl , Jörg Breitenbach , Christiane Vollgraf
IPC分类号： A61K914
CPC分类号： A61K9/2095 , A61K9/2009 , A61K9/2027 , A61K31/192
摘要： A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm3.
摘要翻译： 快速镇痛剂在具有多孔结构且密度大于1至高达2.5g / cm 3的佐剂基质中包含止痛物质布洛芬。
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公开(公告)号：US06787157B1
公开(公告)日：2004-09-07
申请号：US09037792
申请日：1998-03-10
IPC分类号： A61K910
CPC分类号： A61K45/06 , A61K9/146 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/2081 , A61K9/2095 , A61K31/355 , A61K31/375 , A61K2300/00
摘要： A solid or semisolid, at least two-phase active ingredient-containing formulation in which there is multiparticulate incorporation of one of the two phases into a matrix of the other phase, and at least one of the phases contains at least one active ingredient, obtainable by introducing particles of one phase into the other phase in a plastic state, and shaping the material while still plastic.
摘要翻译： 一种固体或半固体，至少两相活性成分的制剂，其中将两相中的一种多颗粒结合到另一相的基质中，并且至少一个相含有至少一种活性成分，可获得 通过将一相的颗粒引入塑料状态的另一相中，并且在塑料的同时成型材料。
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3.发明授权Solid medicaments obtained by extrusion of an isomalt-containing polymer-active substance melt 失效通过挤出异麦芽酮糖醇聚合物 - 活性物质熔体获得的固体药物公开(公告)号：US06187342B1
公开(公告)日：2001-02-13
申请号：US09029362
申请日：1998-02-24
IPC分类号： A61K910
CPC分类号： A61K9/2027 , A61K9/2013 , A61K9/2018 , A61K9/2095 , A61K31/277
摘要： The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients, A) 10-90% by weight of a melt-processable, water-soluble polymer, B) 5-85% by weight of isomalt, and C) 0-5% by weight of lecithin, where the total of all the ingredients is to be equal to 100% by weight.
摘要翻译： 本发明涉及可通过挤出获得的固体药物形式，随后成形无溶剂的熔体，除了一种或多种活性成分之外还包含A）10-90重量％的可熔融加工的水溶性聚合物，B） 5-85重量％的异麦芽糖醇，和C）0-5重量％的卵磷脂，其中所有成分的总量等于100重量％。
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4.发明授权公开(公告)号：US06547997B1
公开(公告)日：2003-04-15
申请号：US09554215
申请日：2000-05-11
IPC分类号： B29C4700
CPC分类号： A61K9/14 , A61K9/1688
摘要： Solvent-free noncrystalline bioactive substances are prepared from the corresponding crystalline bioactive substances in an extruder by melting the substances in the extruder under reduced pressure and in the absence of auxiliaries, cooling and comminuting.
摘要翻译： 无溶剂的非结晶生物活性物质由挤出机中相应的结晶生物活性物质通过在减压下熔融挤出机中的物质，并且在没有助剂，冷却和粉碎的情况下制备。
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公开(公告)号：US06488939B1
公开(公告)日：2002-12-03
申请号：US09857018
申请日：2001-05-31
申请人： Jürgen Zeidler , Jörg Rosenberg , Werner Maier , Jörg Neumann
发明人： Jürgen Zeidler , Jörg Rosenberg , Werner Maier , Jörg Neumann
IPC分类号： A61K900
CPC分类号： A61K9/2072 , A61J3/10
摘要： Solid, elongate dosage forms (10) with a long axis (11) and with a length (L) which is defined by projection of the ends (12, 13) of the dosage form to the long axis, where a cross-sectional area (14, 15, 16) oriented perpendicular to the long axis (11) has an area which is variable along the long axis (11) and increases from a cross-sectional area (15) which is located between the ends (12, 13) and has a minimal area essentially continuously toward the two ends (12, 13) up to in each case a cross-sectional area (14 and 16 respectively) with a maximal area, wherein the distance of the maximal cross-sectional area (14) which is located near one end (12) from the maximal cross-sectional area (16) which is located near the other end (13) is, projected on the long axis (11), more than half the length (L) of the dosage form (10), are described.
摘要翻译： 具有长轴（11）和长度（L）的固体，细长剂型（10），其长度（L）通过将剂型的端部（12,13）投影到长轴而限定，其中横截面积 垂直于长轴线（11）定向的区域（14,15,16）具有沿着长轴线（11）可变的区域，并且从位于端部（12,13）之间的横截面积（15）增加 ）并且具有基本上连续朝向两端（12,13）的最小面积，直到在每种情况下具有最大面积的截面面积（14和16），其中最大横截面积（14,13）的距离 ）位于靠近另一端（13）的最大横截面积（16）附近的一端（12）处，突出在长轴（11）上，大于其长度（L）的一半 描述了剂型（10）。
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