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公开(公告)号：US06322816B1
公开(公告)日：2001-11-27
申请号：US09463849
申请日：2000-02-01
申请人： Jürgen Zeidler , Jörg Neumann , Bernd Leipold , Jörg Rosenberg , Gunther Berndl , Jörg Breitenbach , Christiane Vollgraf
发明人： Jürgen Zeidler , Jörg Neumann , Bernd Leipold , Jörg Rosenberg , Gunther Berndl , Jörg Breitenbach , Christiane Vollgraf
IPC分类号： A61K914
CPC分类号： A61K9/2095 , A61K9/2009 , A61K9/2027 , A61K31/192
摘要： A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm3.
摘要翻译： 快速镇痛剂在具有多孔结构且密度大于1至高达2.5g / cm 3的佐剂基质中包含止痛物质布洛芬。
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公开(公告)号：US06787157B1
公开(公告)日：2004-09-07
申请号：US09037792
申请日：1998-03-10
IPC分类号： A61K910
CPC分类号： A61K45/06 , A61K9/146 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/2081 , A61K9/2095 , A61K31/355 , A61K31/375 , A61K2300/00
摘要： A solid or semisolid, at least two-phase active ingredient-containing formulation in which there is multiparticulate incorporation of one of the two phases into a matrix of the other phase, and at least one of the phases contains at least one active ingredient, obtainable by introducing particles of one phase into the other phase in a plastic state, and shaping the material while still plastic.
摘要翻译： 一种固体或半固体，至少两相活性成分的制剂，其中将两相中的一种多颗粒结合到另一相的基质中，并且至少一个相含有至少一种活性成分，可获得 通过将一相的颗粒引入塑料状态的另一相中，并且在塑料的同时成型材料。
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公开(公告)号：US20130004578A1
公开(公告)日：2013-01-03
申请号：US13608482
申请日：2012-09-10
申请人： Jörg Rosenberg , Ulrich Reinhold , Bernd Liepold , Gunther Berndl , Jörg Breitenbach , Laman Alani , Soumojeet Ghosh
发明人： Jörg Rosenberg , Ulrich Reinhold , Bernd Liepold , Gunther Berndl , Jörg Breitenbach , Laman Alani , Soumojeet Ghosh
IPC分类号： A61K9/00 , A61P31/18 , A61K31/513
CPC分类号： A61K9/1694 , A61K9/1617 , A61K9/1635 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/204 , A61K9/2077 , A61K9/2095 , A61K9/2866 , A61K31/00 , A61K31/426 , A61K31/427 , A61K31/513 , A61K47/32 , A61P31/18 , A61K2300/00
摘要： The present invention provides a pharmaceutical dosage formulation, and more particularly, a pharmaceutical dosage formulation comprising an HIV protease inhibitor.
摘要翻译： 本发明提供药物剂量制剂，更具体地，提供包含HIV蛋白酶抑制剂的药物剂型。
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公开(公告)号：US20090302493A1
公开(公告)日：2009-12-10
申请号：US12279385
申请日：2007-03-12
申请人： Thomas Kessler , Jörg Breitenbach , Christoph Schmidt , Matthias Degenhardt , Jörg Rosenberg , Harald Krull , Gunther Berndl
发明人： Thomas Kessler , Jörg Breitenbach , Christoph Schmidt , Matthias Degenhardt , Jörg Rosenberg , Harald Krull , Gunther Berndl
IPC分类号： B29C47/60
CPC分类号： A61J3/00 , A61K9/2027 , A61K9/2095 , A61K9/2893 , A61K47/32 , B01F7/0045 , B29C35/02 , B29C48/022 , B29C48/03 , B29C48/04 , B29C48/08 , B29C48/2564 , B29C48/268 , B29C48/2886 , B29C48/29 , B29C48/395 , B29C48/40 , B29C48/402 , B29C48/404 , B29C48/505 , B29C48/52 , B29C48/54 , B29C48/55 , B29C48/56 , B29C48/57 , B29C48/625 , B29C48/65 , B29C48/67 , B29C48/76 , B29C48/83 , B29C48/865 , B29C48/875 , B29C48/906 , B29C48/914 , B29K2105/0005 , B29K2105/0035 , B29K2105/0038 , B29K2105/0064 , B29K2105/16
摘要： A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (R; A), (ii) at least one reverse-flight section (D), and (iii) a discharging section (E), wherein the processing elements defining the reverse-flight section (R; D) comprise at least one reverse-flight element (14) which is based on a screw-type element having a conveying direction being opposite to the general conveying direction of the extruder.
摘要翻译： 一种制备活性成分的固体分散体的方法，包括将活性成分和基质形成剂加入到挤出机中并形成均匀的挤出物，其中挤出机包括至少两个旋转轴（2），每个轴 2）承载沿轴向布置的多个处理元件，处理元件限定（i）进料和输送段（R; A），（ii）至少一个反向飞行段（D）和（iii） ）排出部分（E），其中限定反向飞行部分（R; D）的处理元件包括至少一个反向飞行元件（14），该反向飞行元件基于螺旋型元件，其具有与 挤出机的一般输送方向。
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5.发明申请Self-Emulsifying Active Ingredient Formulation and the Use of this Formulation 审中-公开自乳化活性成分配方及使用该配方公开(公告)号：US20120225953A1
公开(公告)日：2012-09-06
申请号：US13449971
申请日：2012-04-18
申请人： Gunther Berndl , Jörg Breitenbach , Robert Heger , Michael Stadler , Peter Wilke , Jörg Rosenberg
发明人： Gunther Berndl , Jörg Breitenbach , Robert Heger , Michael Stadler , Peter Wilke , Jörg Rosenberg
CPC分类号： A61K9/107 , A61K9/1075 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38 , B29C48/04 , B29C48/919
摘要： The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.
摘要翻译： 本发明涉及基于活性成分组分的自乳化制剂和具有脂质组分和粘合剂组分的制剂基质，以及将该制剂用作生命科学领域中的剂型。 本发明还描述了一种通过混合制剂组分以形成塑料混合物并且在适当时通过使用熔体挤出有利地制备配方作为剂型的方法来生产自乳化制剂。 制剂在水或水性介质中自发形成乳液。
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公开(公告)号：US08197829B2
公开(公告)日：2012-06-12
申请号：US10296451
申请日：2001-05-29
申请人： Gunther Berndl , Jörg Breitenbach , Robert Heger , Michael Stadler , Peter Wilke , Jörg Rosenberg
发明人： Gunther Berndl , Jörg Breitenbach , Robert Heger , Michael Stadler , Peter Wilke , Jörg Rosenberg
摘要： The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.
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7.发明授权Mechanically stable pharmaceutical presentations form containing liquid or semisolid surface-active substances 有权包含液体或半固体表面活性物质的机械稳定的药物呈现形式公开(公告)号：US06599528B1
公开(公告)日：2003-07-29
申请号：US09936349
申请日：2001-09-11
IPC分类号： A61K948
CPC分类号： A61K9/1617 , A61K9/1635 , A61K9/1694
摘要： The present invention relates to mechanically stable pharmaceutical presentations for oral administration, comprising in addition to one or more active ingredients and at least one melt-processable matrix-forming excipient more than 10 and up to 40% by weight of a surface-active substance with an HLB of from 2 to 18, which is liquid at 20° C. or has a drop point in the range from 20 to 50° C.
摘要翻译： 本发明涉及用于口服给药的机械稳定的药物表现，除了一种或多种活性成分和至少一种可熔融加工的基质形成赋形剂之外，还含有超过10重量％至多40重量％的表面活性物质， HLB为2至18，其在20℃下为液体或具有在20至50℃范围内的下降点。
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8.发明授权公开(公告)号：US08470347B2
公开(公告)日：2013-06-25
申请号：US10296451
申请日：2001-05-29
申请人： Gunther Berndl , Jörg Breitenbach , Robert Heger , Michael Stadler , Peter Wilke , Jörg Rosenberg
发明人： Gunther Berndl , Jörg Breitenbach , Robert Heger , Michael Stadler , Peter Wilke , Jörg Rosenberg
CPC分类号： A61K9/107 , A61K9/1075 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38 , B29C47/0011 , B29C47/8895
摘要： The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.
摘要翻译： 本发明涉及基于活性成分组分的自乳化制剂和具有脂质组分和粘合剂组分的制剂基质，以及将该制剂用作生命科学领域中的剂型。 本发明还描述了一种通过混合制剂组分以形成塑料混合物并且在适当时通过使用熔体挤出有利地制备配方作为剂型的方法来生产自乳化制剂。 制剂在水或水性介质中自发形成乳液。
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9.发明申请公开(公告)号：US20110123652A1
公开(公告)日：2011-05-26
申请号：US12899227
申请日：2010-10-06
申请人： Gunther Berndl , Jörg Breitenbach , Jörg Rosenberg , Robert Heger , Michael Stadler , Peter Wilke
发明人： Gunther Berndl , Jörg Breitenbach , Jörg Rosenberg , Robert Heger , Michael Stadler , Peter Wilke
IPC分类号： A61K36/752 , A61K31/167
CPC分类号： A61K9/107 , A61K9/1075 , A61K9/1617 , A61K9/1635 , A61K9/1652 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/38 , B29C48/04 , B29C48/919
摘要： The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.
摘要翻译： 本发明涉及基于活性成分组分的自乳化制剂和具有脂质组分和粘合剂组分的制剂基质，以及将该制剂用作生命科学领域中的剂型。 本发明还描述了一种通过混合制剂组分以形成塑料混合物并且在适当时通过使用熔体挤出有利地制备配方作为剂型的方法来生产自乳化制剂。 制剂在水或水性介质中自发形成乳液。
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10.发明授权Solid medicaments obtained by extrusion of an isomalt-containing polymer-active substance melt 失效通过挤出异麦芽酮糖醇聚合物 - 活性物质熔体获得的固体药物公开(公告)号：US06187342B1
公开(公告)日：2001-02-13
申请号：US09029362
申请日：1998-02-24
IPC分类号： A61K910
CPC分类号： A61K9/2027 , A61K9/2013 , A61K9/2018 , A61K9/2095 , A61K31/277
摘要： The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients, A) 10-90% by weight of a melt-processable, water-soluble polymer, B) 5-85% by weight of isomalt, and C) 0-5% by weight of lecithin, where the total of all the ingredients is to be equal to 100% by weight.
摘要翻译： 本发明涉及可通过挤出获得的固体药物形式，随后成形无溶剂的熔体，除了一种或多种活性成分之外还包含A）10-90重量％的可熔融加工的水溶性聚合物，B） 5-85重量％的异麦芽糖醇，和C）0-5重量％的卵磷脂，其中所有成分的总量等于100重量％。
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