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公开(公告)号：US20180258401A1
公开(公告)日：2018-09-13
申请号：US15978918
申请日：2018-05-14
Applicant: JANSSEN BIOTECH, INC.
Inventor： Francis Karanu , Alireza Rezania
CPC classification number: C12N5/0676 , A61K35/39 , C12N2500/90 , C12N2501/115 , C12N2501/117 , C12N2501/155 , C12N2501/16 , C12N2501/385 , C12N2501/415 , C12N2506/02
Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention provides methods of characterization of cells differentiated into cells expressing markers characteristic of the pancreatic endocrine lineage utilizing unique surface markers. The present invention also provides methods to enrich or sort cells expressing markers characteristic of the pancreatic endocrine lineage. The present invention also provides methods to deplete cells that may contaminate populations of cells expressing markers characteristic of the pancreatic endocrine lineage formed by the methods of the present invention, thereby reducing the incidence of tumor formation in vivo following transplantation.
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公开(公告)号：US10329534B2
公开(公告)日：2019-06-25
申请号：US15978918
申请日：2018-05-14
Applicant: JANSSEN BIOTECH, INC.
Inventor： Francis Karanu , Alireza Rezania
Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention provides methods of characterization of cells differentiated into cells expressing markers characteristic of the pancreatic endocrine lineage utilizing unique surface markers. The present invention also provides methods to enrich or sort cells expressing markers characteristic of the pancreatic endocrine lineage. The present invention also provides methods to deplete cells that may contaminate populations of cells expressing markers characteristic of the pancreatic endocrine lineage formed by the methods of the present invention, thereby reducing the incidence of tumor formation in vivo following transplantation.
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