公开(公告)号：US20190117704A1

公开(公告)日：2019-04-25

申请号：US16223724

申请日：2018-12-18

Applicant: Japan Science and Technology Agency

Inventor： Makoto SUEMATSU ,  Yasuhito TOKUMOTO ,  Shinpei TAMAKI

IPC: A61K35/30 ,  C12N5/00 ,  C12M1/34 ,  C12N5/079 ,  C12M3/00

Abstract: The present invention provides a method for producing adult oligodendrocyte progenitor cells from proliferative oligodendrocyte progenitor cells, and a pharmaceutical composition having for an active ingredient thereof adult OPC produced according to that method. The method for producing adult OPC of the present invention is characterized by inducing proliferating OPC to differentiate into adult OPC by culturing in the presence of a ligand of a thyroid hormone receptor or retinoic acid receptor in a low oxygen environment. The present invention further provides adult OPC produced according to the production method of the present invention, and a pharmaceutical composition having these adult OPC as an active ingredient thereof.

公开(公告)号：US20170067020A1

公开(公告)日：2017-03-09

申请号：US15112027

申请日：2015-01-21

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Makoto SUEMATSU ,  Yasuhito TOKUMOTO ,  Shinpei TAMAKI

IPC: C12N5/0797 ,  A61K35/30 ,  G01N33/50

CPC classification number: C12N5/0623 ,  A61K35/30 ,  C12N2500/02 ,  C12N2500/38 ,  C12N2501/385 ,  C12N2501/395 ,  G01N33/5058

Abstract: The present invention provides a method for producing adult oligodendrocyte progenitor cells from proliferative oligodendrocyte progenitor cells, and a pharmaceutical composition having for an active ingredient thereof adult OPC produced according to that method. The method for producing adult OPC of the present invention is characterized by inducing proliferating OPC to differentiate into adult OPC by culturing in the presence of a ligand of a thyroid hormone receptor or retinoic acid receptor in a low oxygen environment. The present invention further provides adult OPC produced according to the production method of the present invention, and a pharmaceutical composition having these adult OPC as an active ingredient thereof.

Abstract translation: 本发明提供了一种从增殖性少突神经母细胞祖细胞产生成体少突胶质细胞祖细胞的方法，以及具有活性成分的成分根据该方法生产的OPC的药物组合物。 本发明的成人OPC的制造方法的特征在于，通过在低氧环境下在甲状腺激素受体或视黄酸受体的配体的存在下培养，诱导增殖OPC分化成成人OPC。 本发明还提供了根据本发明的制备方法制备的成人OPC和具有这些成人OPC作为其活性成分的药物组合物。