公开(公告)号：US20220162220A1

公开(公告)日：2022-05-26

申请号：US17493528

申请日：2021-10-04

Applicant: Japan Tobacco Inc.

Inventor： Masafumi Inoue ,  Yosuke Ogoshi ,  Takayuki Furukawa ,  Takuya Machida ,  Ikuo Mitani ,  Kazuhito Harada ,  Yuichi Nakagawa ,  Nobutaka YAMAOKA

IPC: C07D491/048

Abstract: The present invention provides a compound having a Pim-1 inhibitory activity.
The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like. wherein each symbol is as defined in the description.

公开(公告)号：US20240150367A1

公开(公告)日：2024-05-09

申请号：US18143720

申请日：2023-05-05

Applicant: Japan Tobacco Inc.

Inventor： Satoru Noji ,  Makoto Shiozaki ,  Tomoya Miura ,  Yoshinori Hara ,  Hiroshi Yamanaka ,  Katsuya Maeda ,  Akimi Hori ,  Masafumi Inoue ,  Yasunori Hase

IPC: C07D487/10 ,  A61K31/437 ,  A61K31/438 ,  A61K31/519 ,  A61K31/55 ,  C07D471/10 ,  C07D519/00

CPC classification number: C07D487/10 ,  A61K31/437 ,  A61K31/438 ,  A61K31/519 ,  A61K31/55 ,  C07D471/10 ,  C07D519/00

Abstract: A compound of the following general formula [I]:






wherein each symbol has the same meaning as defined herein, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical use of the same in treating organ transplant rejection, graft versus host reaction after transplantation, autoimmune disease, allergic disease and chronic myeloproliferative disease.

公开(公告)号：US11643417B2

公开(公告)日：2023-05-09

申请号：US17493528

申请日：2021-10-04

Applicant: Japan Tobacco Inc.

Inventor： Masafumi Inoue ,  Yosuke Ogoshi ,  Takayuki Furukawa ,  Takuya Machida ,  Ikuo Mitani ,  Kazuhito Harada ,  Yuichi Nakagawa ,  Nobutaka Yamaoka

IPC: C07D491/048 ,  C07D491/107 ,  C07D519/00 ,  A61K31/551 ,  A61P9/12 ,  A61P11/00 ,  A61P17/06 ,  A61P35/00 ,  A61P43/00

CPC classification number: C07D491/048

Abstract: The present invention provides a compound having a Pim-1 inhibitory activity.
The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like.




wherein each symbol is as defined in the description.

公开(公告)号：US20240116943A1

公开(公告)日：2024-04-11

申请号：US18124389

申请日：2023-03-21

Applicant: Japan Tobacco Inc.

Inventor： Masafumi Inoue ,  Yosuke Ogoshi ,  Takayuki Furukawa ,  Takuya Machida ,  Ikuo Mitani ,  Kazuhito Harada ,  Yuichi Nakagawa ,  Nobutaka Yamaoka

IPC: C07D491/048

CPC classification number: C07D491/048

Abstract: The present invention provides a compound having a Pim-1 inhibitory activity.
The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like.




wherein each symbol is as defined in the description.

公开(公告)号：US10981877B2

公开(公告)日：2021-04-20

申请号：US16319938

申请日：2017-07-28

Applicant: Japan Tobacco Inc.

Inventor： Takahisa Motomura ,  Masafumi Inoue ,  Hirotsugu Ito ,  Takuya Matsuo ,  Koichi Suzawa ,  Hiroshi Yamamoto ,  Tsubasa Takeichi ,  Yasuyuki Kajimoto ,  Takashi Inaba ,  Takao Ito ,  Takahiro Yamasaki ,  Yukishige Ikemoto

IPC: C07D231/12 ,  C07C45/64 ,  C07C43/23 ,  B01J23/44 ,  B01J31/02

Abstract: A production method of a compound represented by the formula [I]: or a pharmaceutically acceptable salt thereof, or a hydrate thereof.

公开(公告)号：US20230023377A1

公开(公告)日：2023-01-26

申请号：US17557174

申请日：2021-12-21

Applicant: Japan Tobacco Inc.

Inventor： Satoru Noji ,  Makoto Shiozaki ,  Tomoya Miura ,  Yoshinori Hara ,  Hiroshi Yamanaka ,  Katsuya Maeda ,  Akimi Hori ,  Masafumi Inoue ,  Yasunori Hase

IPC: C07D487/10 ,  C07D519/00 ,  A61K31/437 ,  A61K31/438 ,  A61K31/519 ,  A61K31/55 ,  C07D471/10

Abstract: A compound of the following general formula [I]: wherein each symbol has the same meaning as defined herein, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical use of the same in treating organ transplant rejection, graft versus host reaction after transplantation, autoimmune disease, allergic disease and chronic myeloproliferative disease.

公开(公告)号：US20140187534A1

公开(公告)日：2014-07-03

申请号：US14077446

申请日：2013-11-12

Applicant: Japan Tobacco Inc.

Inventor： Satoru Noji ,  Makoto Shiozaki ,  Tomoya Miura ,  Yoshinori Hara ,  Hiroshi Yamanaka ,  Katsuya Maeda ,  Akimi Hori ,  Masafumi Inoue ,  Yasunori Hase

IPC: C07D487/10 ,  C07D471/10

CPC classification number: C07D487/10 ,  A61K31/437 ,  A61K31/438 ,  A61K31/519 ,  A61K31/55 ,  C07D471/10 ,  C07D519/00

Abstract: A compound of the following general formula [I]: wherein each symbol has the same meaning as defined herein, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical use of the same in treating organ transplant rejection, graft versus host reaction after transplantation, autoimmune disease, allergic disease and chronic myeloproliferative disease.

Abstract translation: 下列通式[I]的化合物：其中每个符号具有如本文所定义的相同含义，或其药学上可接受的盐或其溶剂合物，以及其用于治疗器官移植排斥，移植物抗宿主 移植后反应，自身免疫性疾病，过敏性疾病和慢性骨髓增生性疾病。