公开(公告)号：US20200339544A1

公开(公告)日：2020-10-29

申请号：US16753847

申请日：2018-10-05

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Kirill Vadimovich ZAVIALOV ,  Svetlana Leonidovna GORBUNOVA ,  Artsiom Evgenievich SHEKHAUTSOU ,  Mariia Andreevna KASATKINA ,  Daria Dmitrievna BEKETOVA ,  Natalia Vladimirovna KOZHEMYAKINA ,  Kirill Igorevich KULISH ,  Elena Aleksandrovna MAKSIMENKO ,  Marina Viktorovna MELESHINA ,  Olga Anatolevna MELCHAEVA ,  Aleksei Leonidovich MINDICH ,  Dmitry Valentinovich MOROZOV ,  Aleksandra Vladimirovna POPKOVA ,  Ilia Alexeevich SMETANIN ,  Sergey Aleksandrovich SILONOV ,  Iaroslavna Alexandrovna SOLDATOVA ,  Georgii Viktorovich IAKOBSON

IPC: C07D403/06 ,  C07D239/42 ,  C07D213/74 ,  C07D413/10 ,  C07D401/06 ,  A61P35/00

Abstract: The present invention relates to novel compounds of formula I, or pharmaceutically acceptable salts, solvates or stereoisomers thereof, also to a pharmaceutical composition, a method for inhibiting biological activity of epidermal growth factor receptor (EGFR), a method for treating diseases or disorders mediated by the activation of EGFR and use of the present compounds or the present pharmaceutical composition for the treatment of a disease or disorder mediated by the activation of EGFR.