公开(公告)号：US20240034764A1

公开(公告)日：2024-02-01

申请号：US18266001

申请日：2021-12-10

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Aleksey Vladimirovich KONONOV ,  Iuliia Viktorovna EVDOKIMOVSKAIA ,  Iana Andreevna SMIRNOVA ,  Stanislav Rudolfovich EVDOKIMOV ,  Elena Sergeevna KOLOSOVA ,  Sergei Andreevich AGEEV ,  Vladimir Sergeevich TSYMPILOV ,  Valery Vladimirovich SOLOVYEV ,  Pavel Andreevich IAKOVLEV ,  Dmitry Valentinovich MOROZOV

IPC: C07K14/54 ,  C12N15/63 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K14/5428 ,  C12N15/63 ,  A61P35/00 ,  C07K16/2818 ,  C07K2319/30

Abstract: The present invention relates to the field of biotechnology and medicine, in particular to an immunocytokine for activating the human IL-10Rα receptor. The invention further relates to nucleic acids encoding said immunocytokine, expression vectors, host cells and methods for producing same, methods for producing the immunocytokine, pharmaceutical compositions comprising the above immunocytokine, pharmaceutical compositions comprising the above immunocytokine and other therapeutically active compounds, methods for treating an oncological disease and the uses of the immunocytokine or pharmaceutical compositions thereof for treating an oncological disease.

公开(公告)号：US20220213209A1

公开(公告)日：2022-07-07

申请号：US17605933

申请日：2020-04-23

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Andrei Borisovich ULITIN ,  Olesya Nikolaevna KOZLOVA ,  Aleksandr Andreevich GORDEEV ,  Ksenia Mihailovna BURNYSHEVA ,  Anastasia Nikolaevna ISHUTINOVA ,  Aleksandra Aleksandrovna SOZONOVA ,  Sergei Andreevich AGEEV ,  Aleksandr Nikolaevich DORONIN ,  Vladimir Sergeevich TSYMPILOV ,  Ivan Vladimirovich MITROSHIN ,  Valery Vladimirovich SOLOVYEV ,  Iakov Iurevich USTIUGOV ,  Roman Alekseevich IVANOV ,  Dmitry Valentinovich MOROZOV

IPC: C07K16/28 ,  C07K16/46 ,  A61P35/00

Abstract: The present invention relates to biotechnology, in particular to antibodies or antigen-binding fragments thereof, and to use thereof. More particularly, the present invention relates to monoclonal antibodies that specifically bind to GITR. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with GITR.