公开(公告)号：US20200031952A1

公开(公告)日：2020-01-30

申请号：US16564148

申请日：2019-09-09

Applicant: CLOSED JOINT STOCK COMPANY "BIOCAD"

Inventor： Andrey Borisovich ULITIN ,  Stanislav Rudolfovich EVDOKIMOV ,  Valeriy Vladimirovich SOLOVIEV ,  Yulia Sergeevna CHERNYKH ,  Olga Vladimirovna GONCHAROVA ,  Dmitriy Valerievich KORZHAVIN ,  Tatyana Veniaminovna CHERNOVSKAYA ,  Timofey Aleksandrovich NEMANKIN ,  Roman Alexeevich IVANOV ,  Dmitriy Valentinovich MOROZOV ,  Victoria Mikhailovna EKIMOVA ,  Ekaterina Vladimirovna SOFRONOVA ,  Yakov Yurevich USTYUGOV

IPC: C07K16/46 ,  A61K39/395 ,  A61K45/06 ,  C07K16/24

Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.

公开(公告)号：US20200369771A1

公开(公告)日：2020-11-26

申请号：US16605865

申请日：2018-04-11

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Andrey Borisovich ULITIN ,  Victoria Mikhailovna EKIMOVA ,  Ekaterina Vladimirovna SOFRONOVA, ,  Yulia Sergeevna CHERNYKH ,  Sergei Andreevich AGEEV ,  Anna Konstantinovna VLADIMIROVA ,  Aleksei Aleksandrovich ALEKSANDROV ,  Pavel Alekseevich GREBNEV ,  Valery Vladimirovich SOLOVYEV ,  Iakov Iurevich USTIUGOV ,  Pavel Andreevich IAKOVLEV ,  Timofey Aleksandrovich NEMANKIN ,  Dmitry Valentinovich MOROZOV

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

Abstract: The present invention relates to the field of biotechnology and provides antibodies that specifically binds to PD-L1. The invention also relates to DNA encoding said antibodies, to corresponding expression vectors and to methods of producing, and to methods of treatment using said antibodies.

公开(公告)号：US20170066843A1

公开(公告)日：2017-03-09

申请号：US15254225

申请日：2016-09-01

Applicant: CLOSED JOINT STOCK COMPANY "BIOCAD"

Inventor： Andrey Borisovich ULITIN ,  Stanislav Rudolfovich EVDOKIMOV ,  Valeriy Vladimirovich SOLOVIEV ,  Yulia Sergeevna CHERNYH ,  Olga Vladimirovna GONCHAROVA ,  Dmitriy Valerievich KORZHAVIN ,  Tatyana Veniaminovna CHERNOVSKAYA ,  Timofey Aleksandrovich NEMANKIN ,  Roman Alexeevich IVANOV ,  Dmitriy Valentinovich MOROZOV ,  Victoria Mikhailovna EKIMOVA ,  Ekaterina Vladimirovna SOFRONOVA ,  Yakov Yurevich USTYUGOV

IPC: C07K16/46 ,  A61K45/06 ,  C07K16/24 ,  A61K39/395

Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.

Abstract translation: 提出了单克隆IgG型抗体，其包含由VHH衍生物与轻链VL的可变结构域组合表示的可变结构域。 所述抗体可以包含位置44和45（Kabat编号）或其组合的氨基酸取代。 本发明的抗体具有增加的亲和力和改进的聚集稳定性。