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公开(公告)号：US20100297063A1
公开(公告)日：2010-11-25
申请号：US12469267
申请日：2009-05-20
申请人： JULIA E. NOVAK , SCOTT R. PRESNELL , CINDY A. SPRECHER , DONALD C. FOSTER , RICHARD D. HOLLY , JANE A. GROOS , JANET V. JOHNSTON , ANDREW J. NELSON , STACEY R. DILLON , ANGELA K. HAMMOND
发明人： JULIA E. NOVAK , SCOTT R. PRESNELL , CINDY A. SPRECHER , DONALD C. FOSTER , RICHARD D. HOLLY , JANE A. GROOS , JANET V. JOHNSTON , ANDREW J. NELSON , STACEY R. DILLON , ANGELA K. HAMMOND
IPC分类号： A61K38/19 , A61P35/00 , A61K38/20 , A61K39/395
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20100297064A1
公开(公告)日：2010-11-25
申请号：US12469303
申请日：2009-05-20
申请人： JULIA E. NOVAK , SCOTT R. PRESNELL , CINDY A. SPRECHER , DONALD C. FOSTER , RICHARD D. HOLLY , JANE A. GROSS , JANET V. JOHNSTON , ANDREW J. NELSON , STACEY R. DILLON , ANGELA K. HAMMOND
发明人： JULIA E. NOVAK , SCOTT R. PRESNELL , CINDY A. SPRECHER , DONALD C. FOSTER , RICHARD D. HOLLY , JANE A. GROSS , JANET V. JOHNSTON , ANDREW J. NELSON , STACEY R. DILLON , ANGELA K. HAMMOND
IPC分类号： A61K38/20 , A61K39/395 , A61K38/19 , A61P35/02
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
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公开(公告)号：US20100222557A1
公开(公告)日：2010-09-02
申请号：US12626307
申请日：2009-11-25
申请人： JULIA E. NOVAK , SCOTT R. PRESNELL , CINDY A. SPRECHER , DONALD C. FOSTER , RICHARD D. HOLLY , JANE A. GROSS , JANET V. JOHNSTON , ANDREW J. NELSON , STACEY R. DILLON , ANGELA K. HAMMOND
发明人： JULIA E. NOVAK , SCOTT R. PRESNELL , CINDY A. SPRECHER , DONALD C. FOSTER , RICHARD D. HOLLY , JANE A. GROSS , JANET V. JOHNSTON , ANDREW J. NELSON , STACEY R. DILLON , ANGELA K. HAMMOND
IPC分类号： C07K16/18
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
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公开(公告)号：US20100266597A1
公开(公告)日：2010-10-21
申请号：US12431623
申请日：2009-04-28
申请人： CINDY A. SPRECHER , ZEREN GAO , JOSEPH L. KUIJPER , MARIA M. DASOVICH , FRANCIS J. GRANT , SCOTT R. PRESNELL , THEODORE E. WHITMORE , ANGELA K. HAMMOND , JULIA E. NOVAK , JANE A. GROSS , STACEY R. DILLON
发明人： CINDY A. SPRECHER , ZEREN GAO , JOSEPH L. KUIJPER , MARIA M. DASOVICH , FRANCIS J. GRANT , SCOTT R. PRESNELL , THEODORE E. WHITMORE , ANGELA K. HAMMOND , JULIA E. NOVAK , JANE A. GROSS , STACEY R. DILLON
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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公开(公告)号：US20100210825A1
公开(公告)日：2010-08-19
申请号：US12540084
申请日：2009-08-12
申请人： WENFENG XU , WAYNE R. KINDSVOGEL , YASMIN A. CHANDRASEKHER , STACEY R. DILLON , JOYCE M. LEHNER , ANTHONY W. SIADAK , PALLAVUR V. SIVAKUMAR , MARGARET DOW MOORE
发明人： WENFENG XU , WAYNE R. KINDSVOGEL , YASMIN A. CHANDRASEKHER , STACEY R. DILLON , JOYCE M. LEHNER , ANTHONY W. SIADAK , PALLAVUR V. SIVAKUMAR , MARGARET DOW MOORE
IPC分类号： C07K16/28
CPC分类号： C07K16/244 , A61K49/0008 , A61K2039/505 , C07K16/2866 , C07K2319/30 , Y10S530/809
摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
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