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公开(公告)号:US20100297064A1
公开(公告)日:2010-11-25
申请号:US12469303
申请日:2009-05-20
申请人: JULIA E. NOVAK , SCOTT R. PRESNELL , CINDY A. SPRECHER , DONALD C. FOSTER , RICHARD D. HOLLY , JANE A. GROSS , JANET V. JOHNSTON , ANDREW J. NELSON , STACEY R. DILLON , ANGELA K. HAMMOND
发明人: JULIA E. NOVAK , SCOTT R. PRESNELL , CINDY A. SPRECHER , DONALD C. FOSTER , RICHARD D. HOLLY , JANE A. GROSS , JANET V. JOHNSTON , ANDREW J. NELSON , STACEY R. DILLON , ANGELA K. HAMMOND
IPC分类号: A61K38/20 , A61K39/395 , A61K38/19 , A61P35/02
CPC分类号: C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译: 描述了与SEQ ID NO:2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列,包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆,单克隆,鼠,人源化或中和的抗体。 还描述了产生抗体的方法。
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公开(公告)号:US20100222557A1
公开(公告)日:2010-09-02
申请号:US12626307
申请日:2009-11-25
申请人: JULIA E. NOVAK , SCOTT R. PRESNELL , CINDY A. SPRECHER , DONALD C. FOSTER , RICHARD D. HOLLY , JANE A. GROSS , JANET V. JOHNSTON , ANDREW J. NELSON , STACEY R. DILLON , ANGELA K. HAMMOND
发明人: JULIA E. NOVAK , SCOTT R. PRESNELL , CINDY A. SPRECHER , DONALD C. FOSTER , RICHARD D. HOLLY , JANE A. GROSS , JANET V. JOHNSTON , ANDREW J. NELSON , STACEY R. DILLON , ANGELA K. HAMMOND
IPC分类号: C07K16/18
CPC分类号: C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译: 描述了与SEQ ID NO:2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列,包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆,单克隆,鼠,人源化或中和的抗体。 还描述了产生抗体的方法。
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公开(公告)号:US20100266597A1
公开(公告)日:2010-10-21
申请号:US12431623
申请日:2009-04-28
申请人: CINDY A. SPRECHER , ZEREN GAO , JOSEPH L. KUIJPER , MARIA M. DASOVICH , FRANCIS J. GRANT , SCOTT R. PRESNELL , THEODORE E. WHITMORE , ANGELA K. HAMMOND , JULIA E. NOVAK , JANE A. GROSS , STACEY R. DILLON
发明人: CINDY A. SPRECHER , ZEREN GAO , JOSEPH L. KUIJPER , MARIA M. DASOVICH , FRANCIS J. GRANT , SCOTT R. PRESNELL , THEODORE E. WHITMORE , ANGELA K. HAMMOND , JULIA E. NOVAK , JANE A. GROSS , STACEY R. DILLON
CPC分类号: C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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公开(公告)号:US20090149635A1
公开(公告)日:2009-06-11
申请号:US12193665
申请日:2008-08-18
申请人: CINDY A. SPRECHER , JOSEPH L. KUIJPER , MARIA M. DASOVICH , FRANCIS J. GRANT , ANGELA K. HAMMOND , JANE A. GROSS
发明人: CINDY A. SPRECHER , JOSEPH L. KUIJPER , MARIA M. DASOVICH , FRANCIS J. GRANT , ANGELA K. HAMMOND , JANE A. GROSS
IPC分类号: C07K16/00
CPC分类号: C07K16/24 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/52 , C07K2317/24
摘要: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译: 本发明涉及zcytor17lig多核苷酸,多肽和抗zcytor17抗体分子。 zcytor17lig是一种新型细胞因子。 多肽可用于刺激免疫系统的方法,体外和体内造血细胞的增殖和/或发育。 本发明还包括生产蛋白质的方法,用途及其抗体。
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公开(公告)号:US20110110946A1
公开(公告)日:2011-05-12
申请号:US12905971
申请日:2010-10-15
申请人: JANE A. GROSS , Wenfeng Xu , Karen L. Madden , David P. Yee
发明人: JANE A. GROSS , Wenfeng Xu , Karen L. Madden , David P. Yee
IPC分类号: A61K39/395 , A61P29/00 , A61P37/06 , A61P37/02 , A61P3/10 , A61P25/28 , A61P11/06 , A61P11/00 , A61P11/08 , A61P13/12 , A61P35/00 , A61P19/02 , A61P7/06
CPC分类号: C07K14/70578 , A61K38/00 , C07K16/2875 , C07K16/2878 , C07K2317/34 , C07K2317/76 , C07K2319/30
摘要: Soluble, secreted tumor necrosis factor receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise one cysteine-rich repeat that is homologous to other tumor necrosis factor receptors, such as transmembrane activator and CAML-interactor (TACI). The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides may also be used in methods that modulate B cell activation.
摘要翻译: 公开了可溶性,分泌的肿瘤坏死因子受体多肽,编码多肽的多核苷酸,以及相关的组合物和方法。 多肽包含与其它肿瘤坏死因子受体如跨膜激活因子和CAML相互作用因子(TACI)同源的富含半胱氨酸的重复序列。 多肽可用于检测配体,激动剂和拮抗剂。 多肽也可用于调节B细胞活化的方法。
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公开(公告)号:US20100130728A1
公开(公告)日:2010-05-27
申请号:US12612288
申请日:2009-11-04
申请人: MARK W. RIXON , JANE A. GROSS
发明人: MARK W. RIXON , JANE A. GROSS
IPC分类号: C07K16/00
CPC分类号: C07K16/241 , A61K38/00 , A61K39/3955 , A61K45/06 , C07K14/70578 , C07K2319/00 , C07K2319/30
摘要: Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptors.
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