公开(公告)号：US09974936B2

公开(公告)日：2018-05-22

申请号：US14426598

申请日：2014-02-20

Applicant: JUVIC INC.

Inventor： Hyung Il Jung ,  Hui Suk Yang

IPC: A61M37/00 ,  A61K9/00 ,  B81C1/00 ,  A61B5/00 ,  A61B17/20

CPC classification number: A61M37/0015 ,  A61B5/685 ,  A61B17/205 ,  A61K9/0021 ,  A61M2037/0053 ,  A61M2207/00 ,  B81C1/00111

Abstract: The present invention is directed to a method for manufacturing a microstructure, the method comprising: (a) placing a viscous composition on a substrate; and (b) applying negative pressure to the viscous composition to induce an extension of the viscous composition, thereby forming a microstructure, and a microstructure manufactured therefor. According to the present invention, a microstructure can be formed without performing a heat treatment by applying a negative pressure. Consequently, it is possible to mount on a microstructure various materials that are sensitive to heat and easily damaged or degenerated. According to the present invention, a microstructure can be manufactured in a non-contacting manner, that is, without being contacted with conventionally used another structure such as a mold or filler. This leads to overcome a loss caused during a process of separating a microstructure in contact or a cutting process involving a physical destruction after the completion of molding a microstructure and limit on the production yield.

公开(公告)号：US10245423B2

公开(公告)日：2019-04-02

申请号：US14889808

申请日：2014-05-02

Applicant: JUVIC INC.

Inventor： Hyung Il Jung ,  Hui Suk Yang ,  Su Yong Kim

IPC: A61M37/00 ,  B29C41/08 ,  C09D101/08 ,  A61K9/50 ,  B29L31/00

Abstract: The present invention relates to a method for manufacturing a microstructure, the method comprising the steps of: (a) preparing a viscous composition on a lower substrate; and (b) applying centrifugal force to the viscous composition to induce extension of the viscous composition, thereby manufacturing a microstructure. According to the present invention, (i) a microstructure having a micro-unit diameter and sufficient effective length and hardness is provided; (ii) any process that may destroy activation of a drug or cosmetic component, such as high-temperature treatment, organic solvent treatment, etc., is avoided; (iii) loss resulting from contact and separation is reduced; (iv) the limitation of aspect ratio of the manufactured microstructure is overcome; (v) the limitation of yield resulting from flatness is overcome; and (vi) microstructures of various shapes can be manufactured.

公开(公告)号：US09943674B2

公开(公告)日：2018-04-17

申请号：US14622716

申请日：2015-02-13

Applicant: JUVIC INC.

Inventor： Hyung Il Jung ,  Hui Suk Yang

IPC: A61M37/00 ,  A61K9/70 ,  A61K9/00 ,  B29C41/12 ,  B29C41/36 ,  A61K9/08 ,  A61K47/36 ,  B29L31/00

CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61K9/0097 ,  A61K9/08 ,  A61K9/703 ,  A61K47/36 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2037/0061 ,  B29C41/12 ,  B29C41/36 ,  B29L2031/7544 ,  B29L2031/756

Abstract: Disclosed are a microstructure-based drug delivery system comprising a microporous structure and a method for manufacturing the same, and more specifically, a detachable microstructure-based drug delivery system using a microporous structure layer and a method for manufacturing the same, thereby skipping a drying step which is essential for the manufacturing process of the existing biodegradable microneedle, and solving the problem in that the hardness of the microneedle is reduced when the microneedle contains drugs, failing to penetrate the skin. Here, the microstructure is implantable in the body through the insertion into the body and detachment from the microporous structure, and the detachable microstructure can be applied to wrinkled (skin movement) and corrugated parts through a detachment function thereof.

公开(公告)号：US11382841B2

公开(公告)日：2022-07-12

申请号：US15744768

申请日：2016-07-13

Applicant: JUVIC INC.

Inventor： Hyung Il Jung ,  Hui Suk Yang

IPC: A61M5/00 ,  A61K8/02 ,  A61K8/67 ,  A61K8/73 ,  A61Q19/02 ,  B81B1/00 ,  B81C1/00 ,  A61K8/49 ,  A61K9/00

Abstract: The present invention relates to a method of manufacturing a microstructure, including: (a) forming a solid on a substrate; (b) fluidizing the solid by adding a solvent thereto; and (c) shaping the fluidized solid, and a microstructure manufactured using the method.

公开(公告)号：US12233229B2

公开(公告)日：2025-02-25

申请号：US17183056

申请日：2021-02-23

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  JUVIC INC.

Inventor： Hyung Il Jung ,  Hui Suk Yang ,  Hyeon Jun Kim

IPC: A61M37/00

Abstract: The present invention relates to a perforated plate microstructure module, and more particularly, to a perforated plate microstructure module which can be used to deliver a drug into the skin.

公开(公告)号：US11104044B2

公开(公告)日：2021-08-31

申请号：US16093587

申请日：2017-04-12

Applicant: JUVIC INC.

Inventor： Hyung Il Jung ,  Hui Suk Yang

IPC: B29C41/50 ,  B29C41/04

Abstract: Provided is a rotating assembly. The rotating assembly is for forming a microstructure, and comprises: a rotating body rotatable about a rotary shaft; a first support member installed on the rotating body so as to be spaced apart from the rotational shaft and having a predetermined viscous composition disposed on an outer surface thereof; and a fluid communicating portion for communicating the inside and the outside of the rotating body, wherein when the rotating body rotates, the viscous composition is pulled in a radially outward direction of the rotary shaft, and the pulled viscous composition is cured through the fluid communicating portion, thereby forming a microstructure.