公开(公告)号：US09974936B2

公开(公告)日：2018-05-22

申请号：US14426598

申请日：2014-02-20

Applicant: JUVIC INC.

Inventor： Hyung Il Jung ,  Hui Suk Yang

IPC: A61M37/00 ,  A61K9/00 ,  B81C1/00 ,  A61B5/00 ,  A61B17/20

CPC classification number: A61M37/0015 ,  A61B5/685 ,  A61B17/205 ,  A61K9/0021 ,  A61M2037/0053 ,  A61M2207/00 ,  B81C1/00111

Abstract: The present invention is directed to a method for manufacturing a microstructure, the method comprising: (a) placing a viscous composition on a substrate; and (b) applying negative pressure to the viscous composition to induce an extension of the viscous composition, thereby forming a microstructure, and a microstructure manufactured therefor. According to the present invention, a microstructure can be formed without performing a heat treatment by applying a negative pressure. Consequently, it is possible to mount on a microstructure various materials that are sensitive to heat and easily damaged or degenerated. According to the present invention, a microstructure can be manufactured in a non-contacting manner, that is, without being contacted with conventionally used another structure such as a mold or filler. This leads to overcome a loss caused during a process of separating a microstructure in contact or a cutting process involving a physical destruction after the completion of molding a microstructure and limit on the production yield.

公开(公告)号：US20180056053A1

公开(公告)日：2018-03-01

申请号：US15686845

申请日：2017-08-25

Applicant: JUVIC INC.

Inventor： Hyung Il JUNG ,  Mi Roo KIM ,  Hui Suk YANG ,  Su Yong KIM ,  Chi Song LEE

IPC: A61M37/00 ,  B05D1/18

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  B05D1/18

Abstract: Provided is a structure for transdermal delivery to deliver a material to a body. The structure for transdermal delivery includes a pillar which is a first dermal infiltration part, a microstructure which is connected to an end of one side of the pillar and serves as a second dermal infiltration part. The microstructure includes a body part formed of a biodegradable viscous composition, and a connection part which includes a first contact surface having viscosity generated by a viscous composition to allow the body part to be connected to the pillar and disposed opposite the end of the one side of the pillar.

公开(公告)号：US12048771B2

公开(公告)日：2024-07-30

申请号：US17283480

申请日：2019-10-04

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  JUVIC INC.

Inventor： Hyungil Jung ,  Huisuk Yang

IPC: A61K9/70 ,  A61K9/00 ,  A61M5/42 ,  A61M37/00

CPC classification number: A61K9/7092 ,  A61M5/422 ,  A61M37/0015 ,  A61K9/0021 ,  A61M2037/0023 ,  A61M2202/048

Abstract: A multifunctional microstructure patch is provided. The multifunctional microstructure patch, according to one embodiment of the present invention, comprises: a base layer having an opening part formed in the center thereof; a plurality of microstructures formed on one surface of the base layer and comprising a first drug; and a cover layer detachably bonded on the other surface of the base layer along the periphery of the opening part, and formed so as to cover the opening part.

公开(公告)号：US20230026393A1

公开(公告)日：2023-01-26

申请号：US17791725

申请日：2020-12-24

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSE UNIVERSITY ,  JUVIC INC.

Inventor： Hyung Il JUNG ,  Hui Suk YANG ,  Hyeon Jun KIM

IPC: A61M37/00 ,  A61K9/00

Abstract: A microneedle applicator is provided. A microneedle applicator according to an embodiment of the present invention comprises: a microneedle array; an operation member disposed on the upper portion of the microneedle array and operating such that a user applies an external force so as to insert a microneedle into skin; a housing for accommodating the microneedle array and the operation member; a first guide member disposed in at least one position on a lateral portion of the operation member or on a lateral portion of an interworking member of the operation member; and a second guide member which is disposed on the inner surface of the housing in a position corresponding to the first guide member so as to be engaged with the first guide member, and allows the first guide member to slide so as to prevent the microneedle array from rotating or horizontally distorting when the microneedle array uniformly vertically descends due to the external force.

公开(公告)号：US10245423B2

公开(公告)日：2019-04-02

申请号：US14889808

申请日：2014-05-02

Applicant: JUVIC INC.

Inventor： Hyung Il Jung ,  Hui Suk Yang ,  Su Yong Kim

IPC: A61M37/00 ,  B29C41/08 ,  C09D101/08 ,  A61K9/50 ,  B29L31/00

Abstract: The present invention relates to a method for manufacturing a microstructure, the method comprising the steps of: (a) preparing a viscous composition on a lower substrate; and (b) applying centrifugal force to the viscous composition to induce extension of the viscous composition, thereby manufacturing a microstructure. According to the present invention, (i) a microstructure having a micro-unit diameter and sufficient effective length and hardness is provided; (ii) any process that may destroy activation of a drug or cosmetic component, such as high-temperature treatment, organic solvent treatment, etc., is avoided; (iii) loss resulting from contact and separation is reduced; (iv) the limitation of aspect ratio of the manufactured microstructure is overcome; (v) the limitation of yield resulting from flatness is overcome; and (vi) microstructures of various shapes can be manufactured.

公开(公告)号：US20170105928A1

公开(公告)日：2017-04-20

申请号：US15105465

申请日：2016-03-28

Applicant: JUVIC INC.

Inventor： Hyung IL JUNG ,  Dangol MANITA

IPC: A61K9/00 ,  A61K31/165 ,  A61K9/50

Abstract: A viscous composition for transdermal drug delivery, a method of preparing the same, and a microstructure device prepared using the viscous composition are provided. Here, the viscous composition includes colloidal particles formed of a combination of a drug and a biodegradable polymer, and the biodegradable polymer includes a first amphiphilic polymer. The use of a solvent can be minimized to homogenize the drug in the biodegradable polymer including the first amphiphilic polymer, thereby forming colloidal particles. Therefore, since a separate solvent cannot be used, the microstructure device is expected to be a transdermal drug delivery system which is safe, efficient or useful for drugs which do not include a proper solvent, show poor bioavailability or have a high molecular weight.

公开(公告)号：US11382841B2

公开(公告)日：2022-07-12

申请号：US15744768

申请日：2016-07-13

Applicant: JUVIC INC.

Inventor： Hyung Il Jung ,  Hui Suk Yang

IPC: A61M5/00 ,  A61K8/02 ,  A61K8/67 ,  A61K8/73 ,  A61Q19/02 ,  B81B1/00 ,  B81C1/00 ,  A61K8/49 ,  A61K9/00

Abstract: The present invention relates to a method of manufacturing a microstructure, including: (a) forming a solid on a substrate; (b) fluidizing the solid by adding a solvent thereto; and (c) shaping the fluidized solid, and a microstructure manufactured using the method.

公开(公告)号：US20220008353A1

公开(公告)日：2022-01-13

申请号：US17283480

申请日：2019-10-04

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  JUVIC INC.

Inventor： Hyungil JUNG ,  Huisuk YANG

IPC: A61K9/70 ,  A61M5/42

Abstract: A multifunctional microstructure patch is provided. The multifunctional microstructure patch, according to one embodiment of the present invention, comprises: a base layer having an opening part formed in the center thereof; a plurality of microstructures formed on one surface of the base layer and comprising a first drug; and a cover layer detachably bonded on the other surface of the base layer along the periphery of the opening part, and formed so as to cover the opening part.

公开(公告)号：US20210170154A1

公开(公告)日：2021-06-10

申请号：US17183056

申请日：2021-02-23

Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  JUVIC INC.

Inventor： Hyung Il JUNG ,  Hui Suk YANG ,  Hyeon Jun KIM

IPC: A61M37/00

Abstract: The present invention relates to a perforated plate microstructure module, and more particularly, to a perforated plate microstructure module which can be used to deliver a drug into the skin.

公开(公告)号：US10737081B2

公开(公告)日：2020-08-11

申请号：US15028007

申请日：2014-06-17

Applicant: JUVIC INC.

Inventor： Hyung Il Jung ,  Shayan Fakhraeli Lahiji

IPC: A61M37/00

Abstract: The present invention relates to a painless and patchless shooting microstructure, and a microstructure shooting device. According to the present invention, it is possible to inject a microstructure into the skin within the time of less than one second, and the inconvenience of waiting for the decomposition of a microstructure and removing a patch are completely overcome. A patch-type conventional technology has a problem wherein it is difficult to be applied to a region having hair, but the present invention completely overcomes this problem. According to the present invention, it is possible to precisely control the permeation depth of a microstructure into the skin by controlling discharge power.