公开(公告)号：US5112758A

公开(公告)日：1992-05-12

申请号：US192015

申请日：1988-05-09

申请人： Jack H. Fellman ,  Andrew S. Goldstein

发明人： Jack H. Fellman ,  Andrew S. Goldstein

IPC分类号： G01N33/483 ,  G01N33/50

CPC分类号： G01N33/50 ,  Y10T436/10 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25 ,  Y10T436/2525 ,  Y10T436/25625

摘要： A method of reducing the viscosity of a body fluid comprises mixing a body fluid with a cationic quaternary ammonium reagent. The body fluid is a mucopolysaccharide-containing body fluid which will be tested for a metabolite.

摘要翻译： 降低体液粘度的方法包括将体液与阳离子季铵试剂混合。 体液是含有粘多糖的体液，将被测试代谢物。

公开(公告)号：US5128136A

公开(公告)日：1992-07-07

申请号：US787556

申请日：1991-11-04

申请人： J. Peter Bentley ,  Jack H. Fellman

发明人： J. Peter Bentley ,  Jack H. Fellman

IPC分类号： A01N59/12 ,  A61K33/18 ,  A61L26/00

CPC分类号： A61L26/0066 ,  A01N59/12 ,  A61K33/18 ,  A61L26/0033 ,  A61L2300/106 ,  A61L2300/404 ,  Y10S514/801

摘要： A stabilized collagen gel is disclosed as are methods of making this collagen gel which is useful as a wound dressing to prevent dehydration of the subject being treated and infection of the wound. The collagen gel of the invention is stabilized by combining collagen (preferably in pharmaceutical grade collagen, which is atelopeptide collagen), with iodine or a composition capable of generating iodine. The collagen is flowable on first mixing and undergoes a phase transition to form a stable gel with sufficient structural integrity to form a wound dressing.

摘要翻译： 公开了一种稳定的胶原凝胶，作为制备该胶原凝胶的方法，其可用作伤口敷料以防止正在治疗的受试者的脱水和伤口的感染。 本发明的胶原凝胶通过将胶原蛋白（优选在药物级胶原，其是肽肽胶原）中与碘或能够产生碘的组合物结合来稳定化。 胶原蛋白在第一次混合时是可流动的，并且经历相变以形成具有足够结构完整性的稳定凝胶以形成伤口敷料。

公开(公告)号：US5017471A

公开(公告)日：1991-05-21

申请号：US236896

申请日：1988-08-26

申请人： Jack H. Fellman

发明人： Jack H. Fellman

IPC分类号： C12Q1/28 ,  G01N33/58

CPC分类号： C12Q1/28 ,  G01N33/581 ,  C12Q2326/00 ,  Y10S435/974

摘要： A storage-stable, non carcinogenic reagent for peroxidase detection useful in the diagnosis of AIDS and other diseases which comprises an aqueous solution of hydrogen peroxide and a chromogen therefor. Chromogens uniquely suitable for the purpose are:5 amino-indole7 amino-indole5 amino-benzimidazole7 amino-benzimidazole5 amino-benzothiazole7 amino-benzothiazole5 amino-benzoxazole7 amino-benzoxazole5 amino-indazole7 amino-indazole

摘要翻译： 用于过氧化物酶检测的储存稳定的非致癌试剂，其用于诊断艾滋病和其它疾病，其包括过氧化氢水溶液和其色原体。 唯一适用于此目的的色原是：5氨基 - 吲哚7氨基 - 吲哚5氨基 - 苯并咪唑7氨基 - 苯并咪唑5氨基 - 苯并噻唑7氨基 - 苯并噻唑5氨基 - 苯并恶唑7氨基 - 苯并恶唑5氨基 - 吲唑7氨基 - 吲唑

公开(公告)号：US06482309B1

公开(公告)日：2002-11-19

申请号：US09694110

申请日：2000-10-19

申请人： Terrence R. Green ,  Jack H. Fellman

发明人： Terrence R. Green ,  Jack H. Fellman

IPC分类号： C25B124

CPC分类号： C02F1/4674 ,  A61L2/035 ,  A61L2/18 ,  C02F1/46104 ,  C02F1/4672 ,  C02F2201/46165 ,  C02F2303/04

摘要： An anti-infective device generally comprising an oxidant generating formulation contained within at least a section of the device configured to electrolytically generate an anti-infective oxidant. The device has at least one of a cathode member and an anode member in the section of the device, configured to electrolyze the oxidant generating formulation to electrolytically generate the anti-infective oxidant. A power source is electrically connected to the cathode and anode members such that current passes between the cathode and anode members. In one embodiment, the oxidant generating formulation comprises a solid dispersed in a polymeric wall of the device. In a presently preferred embodiment, the cathode and anode members are completely embedded within the polymeric wall of the device, although in some embodiments they may be partially embedded within the polymeric wall of the device. In another embodiment, the oxidant generating formulation comprises a solution contained within a chamber in the device. The cathode and anode members are located within the chamber in contact with the solution. The electrolytically generated anti-infective substance is preferably elemental iodine. In one embodiment, the oxidant generating formulation comprises an iodide, which is oxidized at the anode member. In another embodiment, the oxidant generating formulation comprises an iodate which is reduced at the cathode member. Preferably, a proton donor is also present in the iodate containing oxidant generating formulation.

摘要翻译： 一种抗感染装置，通常包含氧化剂生成制剂，其包含在构造成电解产生抗感染氧化剂的装置的至少一部分内。 该装置在装置的截面中具有阴极部件和阳极部件中的至少一个，构造成电解氧化剂发生配方以电解产生抗感染氧化剂。 电源电连接到阴极和阳极部件，使得电流在阴极和阳极部件之间通过。 在一个实施方案中，氧化剂生成制剂包含分散在该装置的聚合物壁中的固体。 在目前优选的实施例中，阴极和阳极构件完全嵌入设备的聚合物壁内，尽管在一些实施方式中，它们可以部分地嵌入设备的聚合物壁内。 在另一个实施方案中，氧化剂生成制剂包含包含在装置中的室内的溶液。 阴极和阳极构件位于室内，与溶液接触。 电解产生的抗感染物质优选为元素碘。 在一个实施方案中，氧化剂生成制剂包含在阳极部件处被氧化的碘化物。 在另一个实施方案中，氧化剂生成制剂包含在阴极部件处还原的碘酸酯。 优选地，质子供体也存在于含碘酸的氧化剂生成制剂中。

公开(公告)号：US5232914A

公开(公告)日：1993-08-03

申请号：US677589

申请日：1991-03-29

申请人： Jack H. Fellman

发明人： Jack H. Fellman

IPC分类号： A61K33/18 ,  A01N59/12 ,  A61K31/70 ,  A61P17/00

CPC分类号： A61K33/18 ,  A01N59/12

摘要： A solid, storage-stable, germicidal, pre-iodine composition comprises in dry admixture with each other a solid oxy-compound of iodine, a solid reducing agent for the oxy-compound of iodine, and a solid desiccant used in amount sufficient to combine during the storage cycle of the composition with ambient and/or endogenous water. The oxy-compounds of iodine are iodic acid, iodine pentoxide, potassium iodate and sodium iodate. Preferred reducing agents are ascorbic acid, dihydroxy fumaric acid, the thiol sugars and cysteine. A preferred combination desiccant and iodine solvating agent is polyvinyl pyrrollidone having a molecular weight of from 10,000 to 1,000,000.The composition is storage-stable for an indefinite period. Upon the addition of water, the oxy-compound of iodine is reduced to nascent iodine, which, in application, serves its well-known germicidal function.

摘要翻译： 固体，储存稳定，杀菌，预碘组合物包含以下物质彼此干燥混合的固体氧化合物的碘，碘的氧化合物的固体还原剂和固体干燥剂，其用量足以组合 在组合物与环境和/或内源水的储存循环期间。 碘的氧化合物是碘酸，五氧化二磷，碘酸钾和碘酸钠。 优选的还原剂是抗坏血酸，二羟基富马酸，硫醇糖和半胱氨酸。 优选的组合干燥剂和碘溶剂是分子量为10,000至1,000,000的聚乙烯基吡咯烷酮。 该组合物在无限期存储稳定。 加入水后，碘的氧化合物被还原成新生的碘，其在应用中可用于其众所周知的杀菌功能。

公开(公告)号：US5326841A

公开(公告)日：1994-07-05

申请号：US370683

申请日：1989-06-23

申请人： Jack H. Fellman

发明人： Jack H. Fellman

IPC分类号： A61B19/04 ,  A61L31/06 ,  C08F226/00 ,  C08G18/08 ,  C08G63/685 ,  C08G77/54 ,  C08F20/04 ,  A61K31/74 ,  C08F20/52 ,  C08F20/70

CPC分类号： C08G77/54 ,  A61L31/06 ,  C08F226/00 ,  C08G18/0814 ,  C08G63/6854 ,  A61B42/00

摘要： Disclosed is an elastomeric article comprising the cross-linked, polymerized product of (i) a quaternary ammonium compound having the formula N.sup.+ R.sub.4 X.sup.- wherein at least one of the R groups is unsaturated alkyl and the remaining R groups alkyl or aryl and X is halogen or a small anion with (ii) a free-radical co-polymerizable compound.

摘要翻译： 公开了一种弹性体制品，其包含交联的聚合产物，其（i）具有式N + R4X-的季铵化合物，其中至少一个R基团是不饱和烷基，剩余的R基团是烷基或芳基，X是 卤素或小阴离子与（ii）自由基可共聚化合物。

公开(公告)号：US5081106A

公开(公告)日：1992-01-14

申请号：US553979

申请日：1990-07-16

申请人： J. Peter Bentley ,  Jack H. Fellman

发明人： J. Peter Bentley ,  Jack H. Fellman

IPC分类号： A61K33/18 ,  A61L26/00

CPC分类号： A61K33/18 ,  A61L26/0033 ,  A61L26/0066 ,  A61L2300/106 ,  A61L2300/404 ,  Y10S514/801 ,  Y10S514/944

摘要： A stabilized collagen gel is disclosed as are methods of making this collagen gel which is useful as a wound dressing to prevent dehydration of the subject being treated and infection of the wound. The collagen gel of the invention is stabilized by combining collagen (preferably a pharmaceutical grade collagen, which is atelopeptide collagen), with iodine or a composition capable of generating iodine. The collagen is flowable on first mixing and undergoes a phase transition to form a stable gel with sufficient structural integrity to form a wound dressing.

摘要翻译： 公开了一种稳定的胶原凝胶，作为制备该胶原凝胶的方法，其可用作伤口敷料以防止正在治疗的受试者的脱水和伤口的感染。 本发明的胶原凝胶通过将胶原（优选药物级胶原，其是肽肽胶原）与碘或能产生碘的组合物组合来稳定。 胶原蛋白在第一次混合时是可流动的，并且经历相变以形成具有足够结构完整性的稳定凝胶以形成伤口敷料。