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公开(公告)号：US06495518B1
公开(公告)日：2002-12-17
申请号：US09450071
申请日：1999-11-29
申请人： Jack J. Hawiger , Daniel Robinson , Ruth Ann Veach , Xue Yan Liu , Danya Liu , Sheila Timmons , Robert D. Collins
发明人： Jack J. Hawiger , Daniel Robinson , Ruth Ann Veach , Xue Yan Liu , Danya Liu , Sheila Timmons , Robert D. Collins
IPC分类号： A61K3816
CPC分类号： C12N15/87 , A61K38/1709 , A61K39/00 , A61K47/62 , A61K47/65 , C07K14/475 , C07K14/50 , C07K14/501 , C07K2319/09 , C07K2319/10 , C07K2319/40 , C12N15/625 , Y02A50/403
摘要： The present invention relates to the delivery of biologically active molecules, such as peptides, nucleic acids and therapeutic agents, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized for purposes such as peptide therapy, gene transfer, and antisense therapy to regulate and/or eradicate systemic inflammatory response syndromes such as endotoxic shock.
摘要翻译： 本发明涉及将生物活性分子例如肽，核酸和治疗剂递送到细胞内部，通过向细胞施用包含与导入感受态信号肽连接的分子的复合物。 这种递送可用于诸如肽治疗，基因转移和反义治疗等目的，以调节和/或根除全身性炎症反应综合征，如内毒素性休克。
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2.发明授权
公开(公告)号：US4703039A
公开(公告)日：1987-10-27
申请号：US786241
申请日：1985-10-09
摘要： The disclosure concerns a synthetic conjugate, methods of constructing this conjugate, and methods of using a conjugate of this type to replace naturally occurring proteins or inhibiting the reaction between a naturally occurring protein and a defined site of biological activity in a vertebrate.
摘要翻译： 本公开涉及合成缀合物，构建该缀合物的方法，以及使用这种缀合物替代天然存在的蛋白质或抑制天然存在的蛋白质与脊椎动物中定义的生物活性位点之间的反应的方法。
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3.发明授权Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls 失效抑制血管性血友病因子与人血小板结合并诱导血小板与血管壁相互作用的方法
公开(公告)号：US4666884A
公开(公告)日：1987-05-19
申请号：US598711
申请日：1984-04-10
摘要： A method of inhibiting von Willebrand factor binding to human platelets induced with thrombin, ADP, or other stimuli has been developed. The administration of the small molecular weight peptide or the synthetic inhibitory molecule of the invention significantly inhibits thrombin or ADP-modified human platelets binding of von Willebrand factor, a plasma protein necessary for platelet interaction with blood vessels. The method of the invention is useful for inhibiting the formation of hemostatic platelet plugs and the initiation of thrombotic lesions. The blockage caused by hemostatic platelet plugs and the damage caused by thrombotic lesions are major factors in heart disease and stroke. The invention also includes a method of inducing the interaction of platelets with blood vessels by administration of a synthetic platelet reactive molecule.
摘要翻译： 已经开发了一种抑制von Willebrand因子结合凝血酶，ADP或其他刺激诱导的人血小板的方法。 本发明的小分子量肽或合成抑制性分子的施用显着抑制凝血酶或ADP修饰的人血小板结合血管性血友病因子，血小板与血管相互作用所必需的血浆蛋白。 本发明的方法可用于抑制止血栓塞形成和血栓形成病变的发生。 止血栓塞造成的堵塞以及由血栓形成病变引起的损伤是心脏病和中风的主要因素。 本发明还包括通过施用合成的血小板反应性分子诱导血小板与血管的相互作用的方法。
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公开(公告)号：US4661471A
公开(公告)日：1987-04-28
申请号：US599477
申请日：1984-04-10
摘要： A method of inhibiting thrombin or ADP-induced human platelet aggregation by fibrinogen has been developed. The administration of the small molecular weight peptide or the synthetic inhibitory molecule of the invention significantly inhibits thrombin or ADP-modified human platelets binding of fibrinogen, a plasma protein necessary for platelet aggregation. The method of the invention is useful for inhibiting of the formation of hemostatic platelet plugs and of the initiation of thrombotic lesions. The blockage caused by hemostatic platelet plugs and the damage caused by thrombotic lesions are major factors in heart disease and stroke. The invention also includes a method of inducing the formation of thrombin or ADP-modified platelet aggregates by administration of a synthetic aggregating molecule which represents a functional substitute for fibrinogen.
摘要翻译： 已经开发了通过纤维蛋白原抑制凝血酶或ADP诱导的人血小板聚集的方法。 本发明的小分子量肽或合成抑制性分子的给药显着抑制凝血酶或ADP修饰的人血小板结合纤维蛋白原，血小板聚集所必需的血浆蛋白。 本发明的方法可用于抑制止血栓塞的形成和血栓形成病变的起始。 止血栓塞造成的堵塞以及由血栓形成病变引起的损伤是心脏病和中风的主要因素。 本发明还包括通过施用代表纤维蛋白原的功能性替代物的合成聚集分子诱导凝血酶或ADP改性的血小板聚集体形成的方法。
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