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1.发明申请Methods for Lowering Elevated Uric Acid Levels Using Intravenous Injections of PEG-Uricase 有权使用静脉注射PEG-Uricase降低尿酸水平升高的方法公开(公告)号：US20070274977A1
公开(公告)日：2007-11-29
申请号：US11539475
申请日：2006-10-06
CPC分类号： A61K38/44 , A61K47/60 , C12Y107/03003
摘要： A method for lowering elevated uric acid levels in patients is disclosed and consists of administering to the patients an intravenous injection of PEG-uricase having a dosage from about 4 to about 12 mg.
摘要翻译： 公开了一种降低患者尿酸水平升高的方法，其中包括给患者静脉注射约4至约12mg剂量的PEG-尿酸酶。
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2.发明授权Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase 有权使用静脉注射PEG-尿酸酶降低尿酸水平的方法公开(公告)号：US08148123B2
公开(公告)日：2012-04-03
申请号：US11539475
申请日：2006-10-06
CPC分类号： A61K38/44 , A61K47/60 , C12Y107/03003
摘要： A method for lowering elevated uric acid levels in patients is disclosed and consists of administering to the patients an intravenous injection of PEG-uricase having a dosage from about 4 to about 12 mg.
摘要翻译： 公开了一种降低患者尿酸水平升高的方法，其中包括给患者静脉注射约4至约12mg剂量的PEG-尿酸酶。
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3.发明申请Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates 有权用于制备非免疫原性聚合物共轭物的无集料的尿酸氧化酶公开(公告)号：US20080057048A1
公开(公告)日：2008-03-06
申请号：US11882750
申请日：2007-08-03
申请人： Merry Sherman , Mark Saifer , L. Williams , Michael Hershfield , Susan Kelly
发明人： Merry Sherman , Mark Saifer , L. Williams , Michael Hershfield , Susan Kelly
CPC分类号： A61K47/48215 , A61K38/00 , A61K47/60 , C12N9/0046 , C12N9/96
摘要： A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.
摘要翻译： 基本上不含大量聚集体的天然存在或重组的蛋白质，特别是猪尿酸氧化酶（尿酸酶）的突变蛋白质可通过与足够少数量的聚合物链共轭而使其基本上不具有免疫原性，使得蛋白质的生物活性 基本上保留在缀合物中。 这种缀合物非常适合用于治疗慢性病症，因为它们与由含有痕量的大聚集体的蛋白质制剂制备的类似共轭物相比不太可能诱导抗体形成和/或加速清除。
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公开(公告)号：US20080031864A1
公开(公告)日：2008-02-07
申请号：US11833590
申请日：2007-08-03
申请人： L. Williams , Michael Hershfield , Susan Kelly , Mark Saifer , Merry Sherman
发明人： L. Williams , Michael Hershfield , Susan Kelly , Mark Saifer , Merry Sherman
CPC分类号： C12N9/0048 , A61K38/00 , A61K47/60 , C12N9/0046 , C12N9/0093 , C12N9/96 , C12Y107/03003
摘要： A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75% of the uricolytic activity of the unmodified enzyme.
摘要翻译： 共价偶联于聚（乙二醇）或聚（环氧乙烷）（均称为PEG））的天然存在或重组的尿酸氧化酶（尿酸酶），其中平均2至10股PEG与每个尿酸酶亚基缀合， PEG具有约5kDa至100kDa的平均分子量。 所得的PEG-尿酸酶缀合物基本上是非免疫原性的，并且保留未修饰酶的尿溶酶活性的至少75％。
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公开(公告)号：US07056713B1
公开(公告)日：2006-06-06
申请号：US09762097
申请日：1999-08-05
申请人： Michael Hershfield , Susan J. Kelly
发明人： Michael Hershfield , Susan J. Kelly
CPC分类号： C12N9/0046
摘要： The present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are particularly useful as, for example, intermediates for making improved modified uricase proteins with reduced immunogenicity and increased bioavailability.
摘要翻译： 本发明一般涉及尿酸氧化酶（尿酸酶）蛋白质和编码其的核酸分子。 特别地，本发明涉及尿嘧啶蛋白质，其特别用作例如用于制备具有降低的免疫原性和增加的生物利用度的改良的改良的尿酸酶蛋白质的中间体。
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公开(公告)号：US20060188971A1
公开(公告)日：2006-08-24
申请号：US11357028
申请日：2006-02-21
申请人： Michael Hershfield , Susan Kelly
发明人： Michael Hershfield , Susan Kelly
IPC分类号： C12N9/06
CPC分类号： C12N9/0046
摘要： The present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are particularly useful as, for example, intermediates for making improved modified uricase proteins with reduced immunogenicity and increased bioavailability.
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