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    Non-invasive quantification of glucose control, aging, and advanced maillard products by stimulated fluorescence
    1.
    发明授权
    Non-invasive quantification of glucose control, aging, and advanced maillard products by stimulated fluorescence 失效
    通过刺激荧光对葡萄糖控制，衰老和晚期美拉德产品进行非侵入性定量

    公开(公告)号：US5601079A

    公开(公告)日：1997-02-11

    申请号：US307125

    申请日：1994-09-16

    申请人： Jacob Y. Wong ,  Bent Formby ,  Charles M. Peterson

    发明人： Jacob Y. Wong ,  Bent Formby ,  Charles M. Peterson

    IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1495 ,  G01N21/27 ,  A61B6/00

    CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/6826

    摘要： An apparatus for measuring the concentration of selected solute in a solution. This apparatus is particulary suitable for measuring the concentration of blood components, such as blood late Maillard products. A beam of exposing light is imaged through a wall of a containment vessel onto a region of the sample adjacent to this wall to induce from said selected solute emission of light that includes at least one emission peak that can be used to calculate the concentration of this solute. At least one detector is positioned to maximize the strength of detected signal, if other components of this solution strongly absorb the emitted light. The exposing light is directed such that the detected signal is maximized as a function of the path of this exposing light. A particular embodiment is a low-cost, non-invasive blood Maillard products concentration detector. In this embodiment, the containment vessel is preferably one of the patient's fingers. At least two additional detected signals are monitored and processed at wavenumbers suitable for eliminating temperatures and pressure effects on the calculated blood glucose levels.

    摘要翻译： 一种用于测量溶液中所选溶质浓度的装置。 该装置特别适用于测量血液成分的浓度，如血后期美拉德产品。 将曝光光束通过容纳容器的壁成像到与该壁相邻的样品的区域上，以诱导所述选定的溶质发射光，其包括至少一个可用于计算该浓度的发射峰 溶质。 如果该解决方案的其他组件强烈地吸收发射的光，则至少设置一个检测器以使检测到的信号的强度最大化。 引导曝光光使得检测到的信号被最大化为该曝光光的路径的函数。 一个特定的实施方案是低成本，无创血液美拉德产品浓度检测器。 在该实施例中，容纳容器优选为患者手指之一。 在适于消除对计算出的血糖水平的温度和压力影响的波数下监测和处理至少两个附加的检测信号。

    Non-invasive blood chemistry measurement by stimulated infrared relaxation emission
    2.
    发明授权
    Non-invasive blood chemistry measurement by stimulated infrared relaxation emission 失效
    通过受刺激的红外弛豫发射进行非侵入性血液化学测量

    公开(公告)号：US5370114A

    公开(公告)日：1994-12-06

    申请号：US852085

    申请日：1992-03-12

    申请人： Jacob Y. Wong ,  Bent Formby ,  Charles M. Peterson

    发明人： Jacob Y. Wong ,  Bent Formby ,  Charles M. Peterson

    IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1495 ,  G01N21/27 ,  A61B6/00

    CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/6826

    摘要： An apparatus for measuring the concentration of a selected solute in a solution. This apparatus is particularly suitable for measuring the concentration of blood components, such as blood glucose. A beam of exposing light is imaged through a wall of a containment vessel onto a region of the sample adjacent to this wall to induce from said selected solute emission of light that includes at least one emission peak that can be used to calculate the concentration of this solute. At least one detector is positioned to maximize the strength of detected signal, if other components of this solution strongly absorb the emitted light. The exposing light is directed such that the detected signal is maximized as a function of the path of this exposing light. A particular embodiment is a non-invasive blood glucose tester that can be used painlessly by diabetics to monitor their blood glucose levels. In this embodiment, the containment vessel is preferably one of the patient's fingers. At least two additional detected signals are monitored and processed at wavenumbers suitable for eliminating temperature and pressure effects on the calculated blood glucose levels.

    摘要翻译： 一种用于测量溶液中选定溶质的浓度的装置。 该装置特别适用于测定血液成分浓度，例如血糖。 将曝光光束通过容纳容器的壁成像到与该壁相邻的样品的区域上，以诱导所述选定的溶质发射光，其包括至少一个可用于计算该浓度的发射峰 溶质。 如果该解决方案的其他组件强烈地吸收发射的光，则至少设置一个检测器以使检测到的信号的强度最大化。 引导曝光光使得检测到的信号被最大化为该曝光光的路径的函数。 一个特定的实施方案是可以由糖尿病患者无痛地用于监测其血糖水平的非侵入性血糖测试仪。 在该实施例中，容纳容器优选为患者手指之一。 在适于消除对计算出的血糖水平的温度和压力影响的波数处监测和处理至少两个额外的检测信号。

    Polynucleic acid sequences that are functionally associated with the development of autoimmune disease
    3.
    发明授权
    Polynucleic acid sequences that are functionally associated with the development of autoimmune disease 失效
    与自身免疫性疾病发展功能相关的多核酸序列

    公开(公告)号：US5763591A

    公开(公告)日：1998-06-09

    申请号：US621502

    申请日：1996-03-25

    申请人： Hiroo Toyoda ,  Bent Formby

    发明人： Hiroo Toyoda ,  Bent Formby

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C07K14/4713 ,  A61K38/00

    摘要： The present invention provides polynucleic acid sequences that are functionally associated with autoimmune diseases, such as, for example, insulin-dependent diabetes mellitus. Significantly, quantities of transcriptional and translational product encoded by the invention polynucleic acid sequences are elevated in mammals having a predisposition to autoimmune disease, as compared to their quantities in normal mammals. In accordance with the present invention, there also are provided polypeptides encoded by the invention polynucleic acid sequences, antibodies that are capable of binding to the invention polypeptides, as well as methods and kits for screening for autoimmune diseases.

    摘要翻译： 本发明提供了与自身免疫性疾病（例如胰岛素依赖性糖尿病）功能相关的多核酸序列。 显着地，与其正常哺乳动物的量相比，本发明编码的多核酸序列的转录和翻译产物的数量在具有自身免疫疾病倾向的哺乳动物中升高。 根据本发明，还提供了由本发明编码的多核酸序列的多肽，能够结合本发明多肽的抗体以及用于筛选自身免疫性疾病的方法和试剂盒。