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公开(公告)号：US20230128198A1
公开(公告)日：2023-04-27
申请号：US17794641
申请日：2021-01-22
发明人： Dai CHENG , Mingming CHEN , Amin LI , Haijun LI , Guiqun YANG
IPC分类号： C07D401/14 , C07D417/14 , C07D405/14 , C07D413/14 , C07D409/14 , C07D401/12
摘要： Provided are compounds of formula (I), or pharmaceutically acceptable salts thereof, which can be used for inhibiting the activity of Aurora A and treating cancer mediated by Aurora A.
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公开(公告)号：US20220119390A1
公开(公告)日：2022-04-21
申请号：US17561381
申请日：2021-12-23
发明人： Haiquan FANG , Mingming CHEN , Guiqun YANG , Yuelei DU , Yanping WANG , Tong WU , Qinglong LI , Lei ZHANG , Shaojing HU
IPC分类号： C07D471/14 , A61P35/00
摘要： Disclosed are tricyclic compounds as bromodomain and extra-terminal (BET) inhibitors which are shown as formula I, their synthesis and their use for treating diseases. More particularly, disclosed are fused heterocyclic derivatives useful as inhibitors of BET, methods for producing such compounds and methods for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.
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公开(公告)号：US20210403582A1
公开(公告)日：2021-12-30
申请号：US17407264
申请日：2021-08-20
发明人： Qinghao LIU , Jun TAO , Wenlai ZHOU , Shanshan HE , Haiyan YANG , Hongling WANG , Guiqun YANG
摘要： Provided is a binding molecule specific for LIF and use thereof. Specifically, provided is an isolated antibody or an antigen-binding fragment thereof that binds to LIF and inhibits the activity of LIF. Also provided are uses of the isolated antibody or the antigen-binding fragment thereof in treatment of diseases.
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公开(公告)号：US20240199548A1
公开(公告)日：2024-06-20
申请号：US18283834
申请日：2022-03-25
发明人： Yang YE , Xiuwei LI , Guiqun YANG , Fashun YAN , Yanping WANG , Wei LONG
IPC分类号： C07D209/44 , A61K31/4035 , A61K31/437 , A61K45/06 , C07D471/04
CPC分类号： C07D209/44 , A61K31/4035 , A61K31/437 , A61K45/06 , C07D471/04
摘要： Compounds of general Formula S-1, S-2, S-3 and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.
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公开(公告)号：US20240116909A1
公开(公告)日：2024-04-11
申请号：US18284897
申请日：2022-03-29
发明人： Yang YE , Xiuwei LI , Guiqun YANG , Fashun YAN , Yanping WANG , Wei LONG
IPC分类号： C07D409/12 , C07D495/04 , C07D519/00 , C07D495/14 , C07D471/04
CPC分类号： C07D409/12 , C07D495/04 , C07D519/00 , C07D495/14 , C07D471/04
摘要： Compounds of general Formula I, II, III, IV, V and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.
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公开(公告)号：US20210179617A1
公开(公告)日：2021-06-17
申请号：US17129983
申请日：2020-12-22
发明人： Haiquan FANG , Mingming CHEN , Guiqun YANG , Yuelei DU , Yanping WANG , Tong WU , Qinglong LI , Lei ZHANG , Shaojing HU
IPC分类号： C07D471/14 , A61P35/00
摘要： Disclosed are tricyclic compounds as bromodomain and extra-terminal (BET) inhibitors which are shown as formula I, their synthesis and their use for treating diseases. More particularly, disclosed are fused heterocyclic derivatives useful as inhibitors of BET, methods for producing such compounds and methods for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.
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