公开(公告)号：US20240336629A1

公开(公告)日：2024-10-10

申请号：US18276269

申请日：2022-01-26

Applicant: JACOBIO PHARMACEUTICALS CO., LTD.

Inventor： Haijun LI ,  Mingming CHEN ,  Di KANG ,  Qinglong LI ,  Lei ZHANG ,  Man YAN ,  Wei LONG ,  Yanping WANG ,  Hao ZHANG ,  Cunbo MA ,  Amin LI

IPC: C07D513/14 ,  C07D471/14 ,  C07D498/14 ,  C12N9/99

CPC classification number: C07D513/14 ,  C07D471/14 ,  C07D498/14 ,  C12N9/99

Abstract: Provided are a compound of formula (I) that inhibit the activity of PARP7, a stereoisomer thereof, a deuterated derivative thereof, or a pharmaceutically acceptable salt thereof, an intermediate to prepare the compound, a process to prepare the compound, a composition comprising the same, and the methods of using the same.

公开(公告)号：US20230128198A1

公开(公告)日：2023-04-27

申请号：US17794641

申请日：2021-01-22

Applicant: JACOBIO PHARMACEUTICALS CO., LTD.

Inventor： Dai CHENG ,  Mingming CHEN ,  Amin LI ,  Haijun LI ,  Guiqun YANG

IPC: C07D401/14 ,  C07D417/14 ,  C07D405/14 ,  C07D413/14 ,  C07D409/14 ,  C07D401/12

Abstract: Provided are compounds of formula (I), or pharmaceutically acceptable salts thereof, which can be used for inhibiting the activity of Aurora A and treating cancer mediated by Aurora A.

公开(公告)号：US20240376075A1

公开(公告)日：2024-11-14

申请号：US18292360

申请日：2022-07-27

Applicant: Jacobio Pharmaceuticals Co., Ltd.

Inventor： Haijun LI ,  Guiqun YANG ,  Wei LONG ,  Yanping WANG

IPC: C07D401/14 ,  A61K31/4545

Abstract: Provided herein are salts of the compound 1 and new poly morph forms thereof, pharmaceutical composition including the compound 1 and new polymorph forms thereof, and methods of preparing them and using them.