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公开(公告)号：US5355394A
公开(公告)日：1994-10-11
申请号：US916835
申请日：1992-08-10
CPC分类号： A61K51/1282 , G21G1/06
摘要： The invention relates to a method for producing actinium-225 and bismuth-213. According to the invention, radium-226 is irradiated in the thermal neutron flux of a nuclear reactor, the thorium fraction of the irradiation product is then chemically isolated and therefrom the actinium and radium mixture growing continuously by decay therein is chemically separated, this mixture serving as "cow" for the desired radionuclides which are growing continuously.
摘要翻译： PCT No.PCT / EP91 / 00306 Sec。 371日期：1992年8月10日 102（e）日期1992年8月10日PCT 1991年2月18日提交PCT公布。 WO91 / 13443 PCT出版物 1991年9月5日，本发明涉及锕-225和铋-213的制造方法。 根据本发明，在核反应堆的热中子通量中照射镭-226，然后化学分离照射产物的钍馏分，由此通过其中的衰变连续生长的锕和镭混合物被化学分离，这种混合物 作为连续生长的所需放射性核素的“牛”。
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公开(公告)号：US06299666B1
公开(公告)日：2001-10-09
申请号：US09647174
申请日：2000-09-27
申请人： Christos Apostolidis , Willem Janssens , Lothar Koch , John McGinley , Roger Molinet , Michel Ougier , Jacques van Geel , Josef Möllenbeck , Hermann Schweickert
发明人： Christos Apostolidis , Willem Janssens , Lothar Koch , John McGinley , Roger Molinet , Michel Ougier , Jacques van Geel , Josef Möllenbeck , Hermann Schweickert
IPC分类号： C22B6002
摘要： This invention refers to a method for producing Actinium-225, comprising the steps of preparing a target (1) containing Radium-226, of irradiating this target with protons in a cyclotron and of chemically separating Actinium from the irradiated target material thereafter. According to the invention the proton energy in the cyclotron is adjusted such that the energy incident on the Ra-226 is between 10 and 20 MeV, preferably between 9 14 and 17 MeV. By this means the yield of production of the desired isotope Ac-225 is enhanced with respect to other radioisotopes.
摘要翻译： 本发明涉及一种制备锕-225的方法，包括以下步骤：制备含有镭-226的靶（1），用回旋加速器中的质子照射该靶，然后在其后化学分离锕。 根据本发明，调整回旋加速器中的质子能量，使得入射在Ra-226上的能量在10MeV之间，优选在914和17MeV之间。 通过这种方式，相对于其它放射性同位素，所需同位素Ac-225的产量提高。
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3.发明授权公开(公告)号：US06485695B1
公开(公告)日：2002-11-26
申请号：US09530670
申请日：2000-05-04
申请人： Lothar Koch , Christos Apostolidis , Roger Molinet , Bruno Brandalise , Willem Janssens , Jacques Van Geel
发明人： Lothar Koch , Christos Apostolidis , Roger Molinet , Bruno Brandalise , Willem Janssens , Jacques Van Geel
IPC分类号： C22B3000
CPC分类号： G21G4/08
摘要： This invention relates to a method and an apparatus for preparing Bi-213 to be integrated in a radioimmunocojugate for human therapeutic use. According to the invention the method comprises the sequence of steps as follows: a) an ampoule 5 containing colloid-free actinium-225, obtained from drying an actinium nitrate solution, is loaded into a container 20 provided with radiation panels 21; b) a dissolving medium is poured into the ampoule 5; c) the solution obtained in the ampoule is transferred into an ion exchange column 6; d) an elution medium is circulated through the column 6; e) the eluate containing eluted Bi-213 is pumped towards a vial 10 for quantification and quality control.
摘要翻译： 本发明涉及一种用于制备Bi-213的方法和装置，以集成在用于人类治疗用途的放射免疫缀合物中。 根据本发明，该方法包括如下步骤：a）将含有无胶体的锕-225的安瓿5装载到设置有辐射面板21的容器20中，该安瓿5从干燥硝酸硝酸溶液获得。 b）将溶解介质倒入安瓿5中; c）将安瓿中得到的溶液转移到离子交换塔6中; d）洗脱介质循环通过柱6; e）将含有洗脱的Bi-213的洗脱液泵送到小瓶10用于定量和质量控制。
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4.发明申请公开(公告)号：US20100020938A1
公开(公告)日：2010-01-28
申请号：US12518289
申请日：2007-12-07
申请人： Lothar Koch , Wolfgang Chrost , Horst Roloff
发明人： Lothar Koch , Wolfgang Chrost , Horst Roloff
IPC分类号： H01J35/14
摘要： A device and method for X-ray tube focal spot parameter control, wherein stray electrons are detected in an X-ray tube. The detected electrons lead to a signal having a characteristic pattern. The characteristic pattern may be evaluated, and based on the evaluation a controlling signal may be outputted so that a fast and exact controlling of the operating parameters of an X-ray tube may be carried out based on the detected stray electrons.
摘要翻译： 用于X射线管焦斑参数控制的装置和方法，其中在X射线管中检测杂散电子。 检测到的电子导致具有特征图案的信号。 可以评估特征图案，并且基于评估，可以输出控制信号，使得可以基于检测到的杂散电子快速且精确地控制X射线管的操作参数。
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公开(公告)号：US06400787B2
公开(公告)日：2002-06-04
申请号：US09861798
申请日：2001-05-21
申请人： Kay Niemax , Lars Hiddemann , Lothar Koch , Jean-Francois Babelot
发明人： Kay Niemax , Lars Hiddemann , Lothar Koch , Jean-Francois Babelot
IPC分类号： G21C1700
CPC分类号： G01N21/718
摘要： Described are a process and an apparatus for the remote measurement of uranium or plutonium in radioactive materials. in which the sample of the material to be analyzed is to be handled as little as possible. To attain that object it is proposed that the laser beam of a laser is focussed by means of a focussing unit onto the sample to be analyzed, so that a light-emitting plasma is generated, an image of the emission spectrum of the plasma is formed in a spectrograph by means of an imaging unit, and finally it is analyzed by means of an analyzing unit.
摘要翻译： 描述了放射性物质远程测量铀或钚的过程和设备。 其中要分析的材料的样品尽可能少地处理。 为了达到该目的，提出将激光的激光束通过聚焦单元聚焦到要分析的样品上，从而产生发光等离子体，形成等离子体的发射光谱的图像 在通过成像单元的光谱仪中，最后通过分析单元进行分析。
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公开(公告)号：US06259757B1
公开(公告)日：2001-07-10
申请号：US09029730
申请日：1998-07-06
申请人： Kay Niemax , Lars Hiddemann , Lothar Koch , Jean-Francois Babelot
发明人： Kay Niemax , Lars Hiddemann , Lothar Koch , Jean-Francois Babelot
IPC分类号： G21C1700
CPC分类号： G01N21/718
摘要： Described are a process and an apparatus for the remote measurement of uranium or plutonium in radioactive materials, in which the sample of the material to be analyzed is to be handled as little as possible. To attain that object it is proposed that the laser beam of a laser is focussed by means of a focussing unit onto the sample to be analyzed, so that a light-emitting plasma is generated, an image of the emission spectrum of the plasma is formed in a spectrograph by means of an imaging unit, and finally it is analyzed by means of an analyzing unit.
摘要翻译： 描述了用于远程测量放射性材料中的铀或钚的方法和装置，其中要分析的材料的样品尽可能少地处理。 为了达到该目的，提出将激光的激光束通过聚焦单元聚焦到要分析的样品上，从而产生发光等离子体，形成等离子体的发射光谱的图像 在通过成像单元的光谱仪中，最后通过分析单元进行分析。
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