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公开(公告)号：US09366673B2
公开(公告)日：2016-06-14
申请号：US13388042
申请日：2010-07-30
IPC分类号： A61K39/02 , A61P31/04 , C07K14/195 , C07K16/12 , A61K39/395 , A61P37/04 , G01N33/569 , A61K39/00
CPC分类号： G01N33/56955 , A61K39/00 , A61K39/0216 , A61K2039/55505 , A61K2039/55566 , C07K16/1257 , G01N2333/21
摘要： Provided herein are compositions and methods for eliciting an immune response against Porphyromonas gingivalis. The compositions and methods relate to P. gingivalis polypeptides and fragments and variants thereof and the corresponding polynucleotides which are useful in the diagnosis, prevention and therapy of P. gingivalis infections (e.g. periodontitis). Antibodies against the polypeptides and compositions and methods including these antibodies are also disclosed. The disclosure also describes methods for the detection, prevention and treatment of P. gingivalis infection (e.g. periodontitis).
摘要翻译： 本文提供了用于引发针对牙龈卟啉单胞菌的免疫应答的组合物和方法。 组合物和方法涉及牙龈卟啉单胞菌多肽及其片段和变体，以及可用于诊断，预防和治疗牙龈卟啉菌感染（例如牙周炎）的相应多核苷酸。 还公开了针对多肽的抗体以及包括这些抗体的组合物和方法。 本公开还描述了牙龈卟啉菌感染（例如牙周炎）的检测，预防和治疗方法。
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公开(公告)号：US20120156211A1
公开(公告)日：2012-06-21
申请号：US13388042
申请日：2010-07-30
IPC分类号： A61K39/02 , A61P31/04 , C07K14/195 , C07K16/12 , A61K39/395 , A61P37/04 , A61K31/7088
CPC分类号： G01N33/56955 , A61K39/00 , A61K39/0216 , A61K2039/55505 , A61K2039/55566 , C07K16/1257 , G01N2333/21
摘要： Provided herein are compositions and methods for eliciting an immune response against Porphyromonas gingivalis. The compositions and methods relate to P. gingivalis polypeptides and fragments and variants thereof and the corresponding polynucleotides which are useful in the diagnosis, prevention and therapy of P. gingivalis infections (e.g. periodontitis). Antibodies against the polypeptides and compositions and methods including these antibodies are also disclosed. The disclosure also describes methods for the detection, prevention and treatment of P. gingivalis infection (e.g. periodontitis).
摘要翻译： 本文提供了用于引发针对牙龈卟啉单胞菌的免疫应答的组合物和方法。 组合物和方法涉及牙龈卟啉单胞菌多肽及其片段和变体，以及可用于诊断，预防和治疗牙龈卟啉菌感染（例如牙周炎）的相应多核苷酸。 还公开了针对多肽的抗体以及包括这些抗体的组合物和方法。 本公开还描述了牙龈卟啉菌感染（例如牙周炎）的检测，预防和治疗方法。
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公开(公告)号：US20160228500A9
公开(公告)日：2016-08-11
申请号：US13555311
申请日：2012-07-23
申请人： Martina Ochs , Roger Brooks , Robert Charlebois , Jeremy Yethon
发明人： Martina Ochs , Roger Brooks , Robert Charlebois , Jeremy Yethon
IPC分类号： A61K38/16 , C07K14/315
CPC分类号： A61K38/164 , A61K38/00 , C07K14/3156 , C07K2319/21
摘要： Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PhtD and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
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公开(公告)号：US20130184200A1
公开(公告)日：2013-07-18
申请号：US13555311
申请日：2012-07-23
申请人： Martina Ochs , Roger Brooks , Robert Charlebois , Jeremy Yethon
发明人： Martina Ochs , Roger Brooks , Robert Charlebois , Jeremy Yethon
IPC分类号： A61K38/16 , C07K14/315
CPC分类号： A61K38/164 , A61K38/00 , C07K14/3156 , C07K2319/21
摘要： Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PhtD and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
摘要翻译： 本文提供了用于引发针对肺炎链球菌的免疫应答的组合物和方法。 更具体地，组合物和方法涉及免疫原性多肽，包括PhtD及其变体的片段，以及编码或表达多肽的核酸，载体和转染细胞。 还描述了制备和使用免疫原性多肽的方法。
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公开(公告)号：US20100297133A1
公开(公告)日：2010-11-25
申请号：US12670150
申请日：2008-07-23
申请人： Martina Ochs , Roger Brookes , Robert Charlebois , Jeremy Yethon
发明人： Martina Ochs , Roger Brookes , Robert Charlebois , Jeremy Yethon
IPC分类号： A61K39/395 , C07K16/12 , G01N33/53 , A61P31/04
CPC分类号： C07K16/1275 , A61K38/00 , A61K39/09 , A61K2039/505 , A61K2039/507 , C07K14/3156 , G01N33/56944
摘要： Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PhtD and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
摘要翻译： 本文提供了用于引发针对肺炎链球菌的免疫应答的组合物和方法。 更具体地，组合物和方法涉及免疫原性多肽，包括PhtD及其变体的片段，以及编码或表达多肽的核酸，载体和转染细胞。 还描述了制备和使用免疫原性多肽的方法。
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公开(公告)号：US08337846B2
公开(公告)日：2012-12-25
申请号：US12670150
申请日：2008-07-23
申请人： Martina Ochs , Roger Brookes , Robert Charlebois , Jeremy Yethon
发明人： Martina Ochs , Roger Brookes , Robert Charlebois , Jeremy Yethon
IPC分类号： A61K39/395 , C07K16/12
CPC分类号： C07K16/1275 , A61K38/00 , A61K39/09 , A61K2039/505 , A61K2039/507 , C07K14/3156 , G01N33/56944
摘要： Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PhtD and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
摘要翻译： 本文提供了用于引发针对肺炎链球菌的免疫应答的组合物和方法。 更具体地，组合物和方法涉及免疫原性多肽，包括PhtD及其变体的片段，以及编码或表达多肽的核酸，载体和转染细胞。 还描述了制备和使用免疫原性多肽的方法。
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公开(公告)号：US20140341942A1
公开(公告)日：2014-11-20
申请号：US14269501
申请日：2014-05-05
申请人： Eliud Oloo , Raymond Oomen , Martina Ochs , Jeremy Yethon
发明人： Eliud Oloo , Raymond Oomen , Martina Ochs , Jeremy Yethon
IPC分类号： C07K14/315 , C07K16/12
CPC分类号： C07K14/3156 , A61K39/092 , A61K2039/505 , A61K2039/55505 , C07K14/315 , C07K16/1275 , C07K2317/76
摘要： This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia The modified pneumolysm proteins comprise ammo acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided
摘要翻译： 本公开涉及缺乏溶血活性并可用作免疫原性组合物或针对由肺炎链球菌引起的侵袭性肺炎球菌疾病的疫苗的免疫原的改良的肺炎链球菌肺炎球菌（PLY）蛋白。经修饰的肺炎球菌蛋白包括在苏氨酸65处的氨基酸取代，甘氨酸 293和半胱氨酸428也提供了核酸，由此编码的多肽，含有其的组合物，使用这些核酸，多肽和组合物的方法
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公开(公告)号：US20110287046A1
公开(公告)日：2011-11-24
申请号：US13140894
申请日：2009-12-22
申请人： Eliud Oloo , Raymond Oomen , Martina Ochs , Jeremy Yethon
发明人： Eliud Oloo , Raymond Oomen , Martina Ochs , Jeremy Yethon
IPC分类号： A61K39/09 , C07H21/00 , C12N15/63 , A61P37/04 , C07K16/12 , C12N1/21 , C12N5/10 , A61P31/04 , C07K14/315 , C12P21/02
CPC分类号： C07K14/3156 , A61K39/092 , A61K2039/505 , A61K2039/55505 , C07K14/315 , C07K16/1275 , C07K2317/76
摘要： This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia. The modified pneumolysm proteins comprise ammo acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided
摘要翻译： 本公开涉及缺乏溶血活性的改良的肺炎链球菌肺炎球菌（PLY）蛋白，其可用作免疫原性组合物或针对由肺炎链球菌引起的侵袭性肺炎球菌疾病的疫苗的免疫原。 修饰的气溶蛋白包括在苏氨酸65，甘氨酸293和半胱氨酸428处的氨基酸取代。还提供了核酸，由此编码的多肽，含有其的组合物，使用此类核酸的方法，多肽和组合物
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公开(公告)号：US20110002962A1
公开(公告)日：2011-01-06
申请号：US12377446
申请日：2007-08-17
IPC分类号： A61K39/09 , C07K14/195 , A61K39/116 , A61P31/04
CPC分类号： C07K14/3156 , G01N33/56944 , G01N2400/10
摘要： Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PcpA and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
摘要翻译： 本文提供了用于引发针对肺炎链球菌的免疫应答的组合物和方法。 更具体地，组合物和方法涉及免疫原性多肽，包括PcpA及其变体的片段，以及编码或表达多肽的核酸，载体和转染的细胞。 还描述了制备和使用免疫原性多肽的方法。
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公开(公告)号：US08758766B2
公开(公告)日：2014-06-24
申请号：US13140894
申请日：2009-12-22
申请人： Eliud Oloo , Raymond Oomen , Martina Ochs , Jeremy Yethon
发明人： Eliud Oloo , Raymond Oomen , Martina Ochs , Jeremy Yethon
IPC分类号： A61K39/00 , A61K39/02 , A61K39/09 , A61K39/38 , C07K14/315
CPC分类号： C07K14/3156 , A61K39/092 , A61K2039/505 , A61K2039/55505 , C07K14/315 , C07K16/1275 , C07K2317/76
摘要： This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia. The modified pneumolysm proteins comprise ammo acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.
摘要翻译： 本公开涉及缺乏溶血活性的改良的肺炎链球菌肺炎球菌（PLY）蛋白，其可用作免疫原性组合物或针对由肺炎链球菌引起的侵袭性肺炎球菌疾病的疫苗的免疫原。 修饰的气溶蛋白包括在苏氨酸65，甘氨酸293和半胱氨酸428处的氨基酸取代。核酸，由此编码的多肽，含有其的组合物，使用此类核酸的方法，多肽和组合物也被提供。
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