公开(公告)号：US06248238B1

公开(公告)日：2001-06-19

申请号：US08845142

申请日：1997-04-21

申请人： Jacques Burtin ,  Michel Thomas ,  Pierre Valette

发明人： Jacques Burtin ,  Michel Thomas ,  Pierre Valette

IPC分类号： B01D6124

CPC分类号： B01D67/0088 ,  A61M1/16 ,  B01D63/021 ,  B01D65/022 ,  B01D67/0093

摘要： A medical apparatus for the extracorporeal treatment of blood or plasma comprises a semi-permeable membrane consisting of at least one electronegative polymer, such that the surface of the semi-permeable membrane has negative electric charges. Before the sterilization of the apparatus, and before or after the formation of the membrane, at least one cationic and anti-protease agent is incorporated in at least one part of the membrane, this agent undergoing bulk adsorption or semi-bulk adsorption in the membrane and/or being bound by an ionic interaction with the electronegative sites of the membrane.

摘要翻译： 用于血液或血浆的体外治疗的医疗装置包括由至少一种电负性聚合物组成的半透膜，使得半透膜的表面具有负电荷。 在装置的灭菌之前，以及在形成膜之前或之后，至少一种阳离子和抗蛋白酶试剂并入膜的至少一部分中，该试剂在膜中进行大量吸附或半散装吸附 和/或通过与膜的电负性位点的离子相互作用结合。

公开(公告)号：US06177013B1

公开(公告)日：2001-01-23

申请号：US09215264

申请日：1998-12-18

申请人： Michel Thomas ,  Pierre Valette

发明人： Michel Thomas ,  Pierre Valette

IPC分类号： B01D6100

CPC分类号： B01D67/0088 ,  A61L33/064 ,  A61L33/068 ,  A61L33/08 ,  B01D63/021 ,  B01D65/022 ,  B01D67/0011 ,  B01D69/02 ,  B01D69/08 ,  B01D69/081 ,  B01D71/42 ,  B01D2321/34 ,  B01D2321/346 ,  B01D2323/08 ,  B01D2323/12 ,  B01D2325/14 ,  B01D2325/26 ,  C08L39/06 ,  C08L79/02 ,  C08L71/02 ,  C08L5/02

摘要： The invention relates to the use of a neutral or cationic polymer for preventing activation of the contact phase of blood or plasma which comes into contact with a semi-permeable membrane based on polyacrylonitrile bearing fixed negative charges, which is fitted in apparatus for the treatment of blood or plasma by extra-corporal circulation, by combination of the neutral or cationic polymer, before or after formation of the membrane and before its sterilization, so as to modify the electrical properties of the membrane, the Zeta potential “Z” and the electrical resistivity “R” in order to obtain: either an electrokinetic index “I” of less than or equal to 0.8, “I” corresponding to Log10 (|Z|/R), or a positive Zeta potential “Z” of between 0 and 15 mV (limits not included).

摘要翻译： 本发明涉及中性或阳离子聚合物用于防止与基于聚丙烯腈的半透膜接触的血液或血浆的接触相活化的固定负电荷的用途，所述聚乙烯腈装在用于治疗 通过体外循环的血液或血浆，通过中性或阳离子聚合物的组合，在膜的形成之前和之后并在其灭菌之前，以改变膜的电性能，Zeta电位“Z”和电 电阻率“R”，以获得小于或等于0.8的电动指数“I”，对应于Log10（| Z | / R）的“I”或0和15之间的正Zeta电位“Z” mV（不包括限制）。

公开(公告)号：US06423232B1

公开(公告)日：2002-07-23

申请号：US09657281

申请日：2000-09-07

申请人： Michel Thomas ,  Pierre Valette

发明人： Michel Thomas ,  Pierre Valette

IPC分类号： B01D6114

CPC分类号： B01D67/0088 ,  A61L33/064 ,  A61L33/068 ,  A61L33/08 ,  B01D63/021 ,  B01D65/022 ,  B01D67/0011 ,  B01D69/02 ,  B01D69/08 ,  B01D69/081 ,  B01D71/42 ,  B01D2321/34 ,  B01D2321/346 ,  B01D2323/08 ,  B01D2323/12 ,  B01D2325/14 ,  B01D2325/26 ,  C08L39/06 ,  C08L79/02 ,  C08L71/02 ,  C08L5/02

摘要： A method for preventing activation of the contact phase of blood or plasma which comes into contact with a semi-permeable membrane based on polyacrylonitrile bearing fixed negative charges, which is fitted in apparatus for the treatment of blood or plasma, by extra-corporal circulation, said method comprising contacting blood or plasma with said semi-permeable membrane, wherein: a neutral or cationic polymer is combined with said semi-permeable membrane before or after formation of the membrane, and before sterilization of the membrane; the overall ionic capacity of the semi-permeable membrane, based on polyacrylonitrile bearing fixed negative charges and containing a neutral or cationic polymer, is negative; the overall ionic capacity of the semi-permeable membrane, based on polyacrylonitrile bearing fixed negative charges and containing a neutral or cationic polymer, is, as an absolute value, not more than 10% less than the overall ionic capacity of the same semi-permeable membrane without a neutral or cationic polymer, at least one of said polymer being present at the surface of the membrane; the semi-permeable membrane based on polyacrylonitrile bearing fixed negative charges and containing a neutral or cationic polymer complies, before sterilization, with the following two electrical characteristic: the electrokinetic index “I” is less than or equal to 0.8, “I” being equal to the logarithm, in base 10, of the ratio |Z|/R, where “Z” is the Zeta potential, as an absolute value, expressed in microvolts, of the surface of the membrane intended to come into contact with blood or plasma, and where “R” is the electrical resistivity of the membrane, expressed in ohm.centimeters, and the Zeta potential “Z” is negative.

摘要翻译： 一种用于防止与基于聚丙烯腈的半透膜接触的血液或血浆的接触相的活化的方法，所述聚合物具有固定的负电荷，其通过体外循环装配在用于治疗血液或血浆的装置中， 所述方法包括使血液或血浆与所述半透膜接触，其中：中膜或阳离子聚合物在所述膜形成之前或之后以及所述膜消毒之前与所述半透膜结合; 基于具有固定负电荷且含有中性或阳离子聚合物的聚丙烯腈的半透膜的总体离子容量为负数; 基于具有固定负电荷且含有中性或阳离子聚合物的聚丙烯腈的半透膜的总体离子容量作为绝对值不超过相同半渗透性的总体离子容量的10％以下 膜，不含中性或阳离子聚合物，所述聚合物中的至少一种存在于膜的表面; 基于具有固定负电荷且含有中性或阳离子聚合物的聚丙烯腈的半透膜在灭菌前符合以下两个电特性：电动指数“I”小于或等于0.8，“I”相等 以碱为基准10的比例| Z | / R，其中“Z”为ζ电位的绝对值（以微伏表示），用于与血液或血浆接触的膜表面 ，并且其中“R”是膜的电阻率，以欧姆计为单位，并且Zeta电位“Z”为负。

公开(公告)号：US06454998B1

公开(公告)日：2002-09-24

申请号：US09364052

申请日：1999-07-30

申请人： Michel Thomas ,  Pierre Valette

发明人： Michel Thomas ,  Pierre Valette

IPC分类号： A61M3700

CPC分类号： A61M1/16 ,  A61L33/068 ,  A61M1/3672 ,  A61M1/3673 ,  B01D61/28 ,  B01D63/021 ,  B01D65/022 ,  B01D67/0088 ,  B01D67/0093 ,  B01D71/42 ,  B01D2313/13 ,  B01D2321/34 ,  B01D2321/346 ,  C08L79/02

摘要： A coupling is connectable to an access of a blood compartment. The compartment has at least one inner surface intended to be coated with at least one molecular layer of a substance soluble in an aqueous solution and capable of increasing biocompatibility. A determined quantity of the substance is deposited inside the coupling in a form such that the substance is capable of undergoing, substantially without deterioration, an irradiation capable of sterilizing the coupling.

摘要翻译： 联接器可连接到血液隔室的通路。 隔室具有至少一个内表面，其旨在涂覆有至少一种可溶于水溶液的物质的分子层并且能够增加生物相容性。 确定量的物质以耦合器内部的形式沉积，使得物质能够基本上不损坏能够消除联接器的照射。

公开(公告)号：US6010475A

公开(公告)日：2000-01-04

申请号：US933032

申请日：1997-09-18

申请人： Michel Thomas ,  Pierre Valette

发明人： Michel Thomas ,  Pierre Valette

IPC分类号： A61L33/06 ,  A61M1/16 ,  A61M1/18 ,  A61M1/36 ,  B01D63/02 ,  B01D67/00 ,  A61M37/00 ,  A61M1/14 ,  A61L13/00

CPC分类号： A61M1/16 ,  A61L33/068 ,  A61M1/3672 ,  B01D61/28 ,  B01D63/021 ,  B01D65/022 ,  B01D67/0088 ,  B01D67/0093 ,  B01D71/42 ,  B01D2313/13 ,  B01D2321/34 ,  B01D2321/346

摘要： An apparatus for the treatment of blood or plasma by extracorporeal circulation includes a compartment for the circulation of blood. The compartment is provided with two accesses and has at least one inner surface intended to be coated, after sterilization, with at least one molecular layer of a substance soluble in an aqueous solution. The aqueous solution is capable of increasing the bicompatibility of the inner surface of the compartment. A determined quantity of the substance is deposited inside the blood compartment, at one of the accesses, in a form such that the substance is capable of undergoing, substantially without deterioration, an irradiation capable of sterilizing the apparatus. The quantity of substance is determined such that the circulation of a determined volume of aqueous solution through the blood compartment, starting from the access where the substance has been deposited, should result in the formation, by durable bonding, of at least one molecular layer of the substance on the inner surface of the blood compartment to be treated.

摘要翻译： 用于通过体外循环治疗血液或血浆的装置包括用于血液循环的隔室。 隔室设置有两个通道，并且具有至少一个内表面，其在灭菌后具有可溶于水溶液的物质的至少一个分子层。 水溶液能够增加隔室内表面的双相容性。 确定量的物质沉积在血液隔室内，在一个通路中，以使得物质能够基本上不会劣化能够对该装置进行灭菌的照射的形式进行。 确定物质的量，使得从沉积物质的入口开始，确定体积的水溶液通过血液隔室的循环将导致通过耐久结合形成至少一个分子层 待处理血液室内表面上的物质。