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    METHOD FOR STERILIZING BLOOD PURIFIER AND BLOOD PURIFIER PACKAGE
    1.
    发明申请
    METHOD FOR STERILIZING BLOOD PURIFIER AND BLOOD PURIFIER PACKAGE 审中-公开
    灭菌血液净化器和血液净化器包装的方法

    公开(公告)号：US20150320921A1

    公开(公告)日：2015-11-12

    申请号：US14722898

    申请日：2015-05-27

    申请人： Takashi SUNOHARA ,  Yuuki HATAKEYAMA ,  Noriko MONDEN ,  Toshiaki MASUDA ,  Noriaki KATO ,  Kimihiro MABUCHI

    发明人： Kimihiro MABUCHI ,  Noriko MONDEN ,  Noriaki KATO ,  Yuuki HATAKEYAMA ,  Takashi SUNOHARA ,  Toshiaki MASUDA

    IPC分类号： A61M1/16 ,  B01D63/02 ,  B01D65/02 ,  B01D61/28

    CPC分类号： A61M1/169 ,  A61L2/087 ,  A61L2202/22 ,  A61M1/168 ,  A61M1/1682 ,  B01D61/28 ,  B01D63/02 ,  B01D65/022 ,  B01D67/0097 ,  B01D2321/28 ,  B01D2321/34

    摘要： The invention provides a method for sterilizing a blood purifier, as well as a blood purifier package. The method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and is highly reliable in safety when employed for hemocatharsis therapy. The method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.

    摘要翻译： 本发明提供了对血液净化器以及血液净化器包装进行灭菌的方法。 该方法有效地减少归因于在放射线或电子射线暴露期间和之后随着时间的选择性渗透分离膜的劣化的血液净化器的提取物的量，并且当用于血液透析治疗时其安全性是高度可靠的 。 通过将相同的血液净化器暴露于放射线和/或电子射线，将包含基本上干燥的选择性渗透性分离膜作为主要成分的血液净化器灭菌的方法的特征在于，将血液净化器密封 在包装袋中，与除氧剂和保湿剂一起，或与能够释放水分的除氧剂一起，然后通过上述曝光在这样的密封状态下灭菌。

    Method for sterilizing blood purifier and blood purifier package
    3.
    发明授权
    Method for sterilizing blood purifier and blood purifier package 有权
    灭菌方法和血液净化器包装

    公开(公告)号：US09056280B2

    公开(公告)日：2015-06-16

    申请号：US11577235

    申请日：2005-10-13

    申请人： Kimihiro Mabuchi ,  Noriko Monden ,  Noriaki Kato ,  Yuuki Hatakeyama ,  Takashi Sunohara ,  Toshiaki Masuda

    发明人： Kimihiro Mabuchi ,  Noriko Monden ,  Noriaki Kato ,  Yuuki Hatakeyama ,  Takashi Sunohara ,  Toshiaki Masuda

    IPC分类号： A61L2/00 ,  B01D65/02 ,  A61L2/08 ,  B01D67/00 ,  A61M1/16

    CPC分类号： A61M1/169 ,  A61L2/087 ,  A61L2202/22 ,  A61M1/168 ,  A61M1/1682 ,  B01D61/28 ,  B01D63/02 ,  B01D65/022 ,  B01D67/0097 ,  B01D2321/28 ,  B01D2321/34

    摘要： The present invention provides a method for sterilizing a blood purifier, which method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and which method is highly reliable in safety when employed for hemocatharsis therapy. The present invention also provides a blood purifier package.The present invention relates to a method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, and this method is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.

    摘要翻译： 本发明提供了一种对血液净化器进行灭菌的方法，该方法有效地减少归因于选择性渗透性分离膜的劣化的血液净化器的提取物的量随着放射线或电子射线暴露期间和之后的时间而变化 ，哪种方法在用于血液渗透治疗时安全性高度可靠。 本发明还提供一种血液净化器包装。 本发明涉及一种用于对通过将相同的血液净化器暴露于放射线和/或电子射线的基本干燥的选择性渗透性分离膜作为主要成分的血液净化器进行灭菌的方法，该方法是 其特征在于，将血液净化器与除氧剂和保湿剂一起密封在包装袋中，或与能够释放水分的除氧剂一起密封，然后通过上述曝光在这样的密封状态下灭菌。

    Method of treating a cellulosic hollow fiber
    5.
    发明授权
    Method of treating a cellulosic hollow fiber 失效
    处理纤维素中空纤维的方法

    公开(公告)号：US4609728A

    公开(公告)日：1986-09-02

    申请号：US511784

    申请日：1983-07-07

    申请人： Kurt Spranger ,  Bernd A. W. Beck

    发明人： Kurt Spranger ,  Bernd A. W. Beck

    IPC分类号： D01F11/02 ,  A61L2/07 ,  A61L2/08 ,  A61L2/20 ,  A61M1/18 ,  B01D65/02 ,  B01D65/06 ,  B01D67/00 ,  B01D71/10 ,  B01D13/04

    CPC分类号： B01D67/0088 ,  A61L2/07 ,  A61L2/08 ,  A61L2/20 ,  B01D65/022 ,  B01D67/0095 ,  B01D2321/08 ,  B01D2321/34

    摘要： Method of treating a cellulosic hollow fiber which is being particularly adapted for use in hemodialysis or a similar extracorporeal treatment of blood.According to the described method the hollow fiber, possibly after rinsing with an alcoholic solution or fluorinated hydrocarbons, is exposed to swelling with use of an aqueous solution prior to drying and/sterilization of the hollow fiber.Examples of aqueous solutions can be water, water/glycerol, and water/glycerol/alcohol. Preferably said aqueous solution contains glycerol in an amount of 4-35%, such as 12-35%, preferably 16-35%.The aqueous solution can be applied to the inside and/or the outside of the hollow fiber so as to bring about a diffusive and/or a convective transport of water and/or glycerol into the hollow fiber wall. The rate of diffusion can be increased by increasing the temperature of the aqueous solution, by increasing the contact time between the aqueous solution and the hollow fiber, or by increasing the glycerol content of the aqueous solution, and the convective transport of said substances is achieved by applying the aqueous solution under pressure.After drying, the hollow fiber can be sterilized either by temperature or by radiation without any substantial loss of permeability characteristics.

    摘要翻译： 特别适用于血液透析或血液类似体外治疗的纤维素中空纤维的处理方法。 根据所述方法，中空纤维可能在用醇溶液或氟化烃漂洗之后，在中空纤维的干燥和/灭菌之前，使用水溶液暴露于溶胀状态。 水溶液的实例可以是水，水/甘油和水/甘油/醇。 优选地，所述水溶液含有4-35％的甘油，例如12-35％，优选16-35％的甘油。 水溶液可以施加到中空纤维的内部和/或外部，以使水和/或甘油进入中空纤维壁的扩散和/或对流运输。 通过增加水溶液的温度，通过增加水溶液和中空纤维之间的接触时间，或通过增加水溶液的甘油含量，可以提高扩散速率，并实现所述物质的对流运输 通过在压力下施加水溶液。 干燥后，可以通过温度或辐射对中空纤维进行灭菌，而不会明显地损失渗透性。

    Materials and Methods for Reducing Biofouling in Water Treatment Membrane Systems
    7.
    发明申请
    Materials and Methods for Reducing Biofouling in Water Treatment Membrane Systems 有权
    减少生物污垢在水处理膜系统中的材料和方法

    公开(公告)号：US20160107126A1

    公开(公告)日：2016-04-21

    申请号：US14882773

    申请日：2015-10-14

    申请人： Clemson University

    发明人： Ezra Lucas Hoyt Cates

    IPC分类号： B01D65/02 ,  B01D63/02 ,  B01D63/10 ,  C02F1/44 ,  C02F1/469

    CPC分类号： C02F1/4695 ,  B01D63/02 ,  B01D63/10 ,  B01D65/08 ,  B01D2321/168 ,  B01D2321/34 ,  C02F1/307 ,  C02F1/44 ,  C02F1/441 ,  C02F1/442 ,  C02F1/444 ,  C02F1/445 ,  C02F1/447 ,  C02F2303/20

    摘要： Methods and systems for preventing biofouling of membranes utilized in water treatment processes (i.e., water treatment membranes) are described. Methods include X-ray excitation of luminescent materials capable of emitting in the violet to UV range (e.g., from about 180 nm to about 440 nm). X-rays are directed at water treatment modules to contact the luminescent materials within the modules and excite internal violet/UV to prevent biofouling of membranes. The methods can be utilized in conjunction with existing processing equipment and can prevent biofouling of water treatment membranes in high volume treatment processes in an environmentally friendly fashion.

    摘要翻译： 描述了用于防止在水处理过程中使用的膜的生物污垢的方法和系统（即，水处理膜）。 方法包括能够在紫外发射到UV范围（例如，约180nm至约440nm）的发光材料的X射线激发。 X射线指向水处理模块以接触模块内的发光材料并激发内部紫/紫外线以防止膜的生物污损。 这些方法可以与现有的加工设备一起使用，并且可以以环保的方式防止水处理膜在大量处理过程中的生物污染。

    Method For Sterilizing Blood Purifier And Blood Purifier Package
    8.
    发明申请
    Method For Sterilizing Blood Purifier And Blood Purifier Package 有权
    消毒血液净化器和血液净化器包装方法

    公开(公告)号：US20080087599A1

    公开(公告)日：2008-04-17

    申请号：US11577235

    申请日：2005-10-13

    申请人： Kimihiro Mabuchi ,  Noriko Monden ,  Noriaki Kato ,  Yuuki Hatakeyama ,  Takashi Sunohara ,  Toshiaki Masuda

    发明人： Kimihiro Mabuchi ,  Noriko Monden ,  Noriaki Kato ,  Yuuki Hatakeyama ,  Takashi Sunohara ,  Toshiaki Masuda

    IPC分类号： A61L2/08 ,  B01D63/00 ,  B01D63/02

    CPC分类号： A61M1/169 ,  A61L2/087 ,  A61L2202/22 ,  A61M1/168 ,  A61M1/1682 ,  B01D61/28 ,  B01D63/02 ,  B01D65/022 ,  B01D67/0097 ,  B01D2321/28 ,  B01D2321/34

    摘要： The present invention provides a method for sterilizing a blood purifier, which method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and which method is highly reliable in safety when employed for hemocatharsis therapy. The present invention also provides a blood purifier package.The present invention relates to a method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, and this method is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.

    摘要翻译： 本发明提供了一种对血液净化器进行灭菌的方法，该方法有效地减少归因于选择性渗透性分离膜的劣化的血液净化器的提取物的量随着放射线或电子射线暴露期间和之后的时间而变化 ，哪种方法在用于血液渗透治疗时安全性高度可靠。 本发明还提供一种血液净化器包装。 本发明涉及一种用于对通过将相同的血液净化器暴露于放射线和/或电子射线的基本干燥的选择性渗透性分离膜作为主要成分的血液净化器进行灭菌的方法，该方法是 其特征在于，将血液净化器与除氧剂和保湿剂一起密封在包装袋中，或与能够释放水分的除氧剂一起密封，然后通过上述曝光在这样的密封状态下灭菌。