公开(公告)号：US20130297040A1

公开(公告)日：2013-11-07

申请号：US13979642

申请日：2012-01-16

申请人： Jacques Donnez ,  Anne Van Langendonkt ,  Sylvie Defrère ,  Jean-Michel Foidart ,  Christine Jérome ,  Brigitte Evrard ,  Raphaël Riva ,  Fabrice Krier ,  Mélanie Mestdagt

发明人： Jacques Donnez ,  Anne Van Langendonkt ,  Sylvie Defrère ,  Jean-Michel Foidart ,  Christine Jérome ,  Brigitte Evrard ,  Raphaël Riva ,  Fabrice Krier ,  Mélanie Mestdagt

IPC分类号： A61K9/00

CPC分类号： A61K9/00 ,  A61K9/0024 ,  A61K31/138 ,  A61K31/192 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/565 ,  A61K31/566 ,  A61K31/567 ,  A61K31/57 ,  A61K31/635 ,  A61K38/09

摘要： The present invention relates to an implant comprising: —a core material comprising polydimethylsiloxane or at least one hydrogel polymer; —a tube encasing said core material comprising an ethylene vinyl acetate polymer or at least one hydrogel polymer; —a sealant for closure of the open ends of said tube comprising polydimethylsiloxane or a mono-, di-, or triacetoxy derivative thereof, or at least one hydrogel polymer; and —at least one active ingredient; wherein said at least one active ingredient is selected from the group comprising celecoxib, sulindac, tamoxifen, oestrogen, oestradiol, ethinyl oestradiol, mestranol, dienogest, norgestrel, levonorgestrel, desogestrel, norgestimate, ethynodiol diacetate, leuprorelin, buserelin, gonrelin, triptorelin, nafarelin, deslorelin, histrelin, and supprelin; and with the proviso that when the sealant is said at least one hydrogelpolymer, the core material comprises polydimethylsiloxane. Furthermore, the invention relates to an implant for use as a medicament. In particular, the invention relates to an implant for use in the treatment of endometriosis.

摘要翻译： 本发明涉及一种植入物，其包含： - 包含聚二甲基硅氧烷或至少一种水凝胶聚合物的核心材料; - 包围所述芯材料的管，其包含乙烯乙酸乙烯酯聚合物或至少一种水凝胶聚合物; - 用于封闭所述管的开口端的密封剂，其包含聚二甲基硅氧烷或其单 - ，二 - 或三乙酰氧基衍生物或至少一种水凝胶聚合物; 和至少一种活性成分; 其中所述至少一种活性成分选自塞来昔布，舒林酸，他莫昔芬，雌激素，雌二醇，炔雌醇，雌孕酮，依诺孕，炔诺孕酮，左炔诺孕酮，去氧孕烯，诺孕酯，炔雌醇二乙酸酯，亮丙瑞林，布舍瑞林，天冬氨素，曲普瑞林， ，deslorelin，histrelin和supprelin; 并且条件是当密封剂被称为至少一种水凝胶聚合物时，芯材料包括聚二甲基硅氧烷。 此外，本发明涉及用作药物的植入物。 特别地，本发明涉及用于治疗子宫内膜异位症的植入物。

公开(公告)号：US20100185211A1

公开(公告)日：2010-07-22

申请号：US12665504

申请日：2008-06-12

申请人： Benoit Herman ,  Benoit Raucent ,  Khanh Tran Duy ,  Jacques Donnez ,  Roland Polet

发明人： Benoit Herman ,  Benoit Raucent ,  Khanh Tran Duy ,  Jacques Donnez ,  Roland Polet

IPC分类号： A61B19/00

CPC分类号： B25J9/1065 ,  A61B34/30 ,  A61B90/11 ,  A61B90/50 ,  A61B2090/506 ,  B25J17/0266

摘要： The present invention concerns hybrid manual-robotic system for supporting and moving a surgical instrument having active main structure (100) that comprises: a) a base (2) for attachment to an operating table having an operating surface (150); b) a hexahedral-shape frame (3), which shape is formed from a first (5, 5′) and second (4, 4′) pair of opposing parallelograms and opposing proximal (6′) and distal (6) rectangles, which frame (3) is formed by at least seven links (7, 8, 9, 10, 11, 12, 13, 22, 23) connected by revolute joints (14, 15, 16, 17, 18, 19, 20, 26, 27, 109), whereby a) a pair of parallel base links (7, 13) of the proximal rectangle (6′) is coupled to the base (2) by two revolute joints (116, 117), and are configured to lie and remain essentially perpendicular to the plane of the 10 operating surface (150) and to revolve around their longitudinal axes that coincide with the axes of revolution of joints (116, 117), whereby b) said revolute joints are configured to allow the hexahedral frame (3) to freely adopt a cube, or parallelepiped restricted by said perpendicular coupling; and whereby c) the distal rectangle (6) is coupled through a transmission means (200) to said instrument.

摘要翻译： 本发明涉及用于支撑和移动具有活动主体结构（100）的手术器械的混合手动机器人系统，其包括：a）用于附接到具有操作表面（150）的操作台的基座（2）; b）六面体形框架（3），其形状由第一（5,5'）和第二（4,4''）对相对平行四边形和相对的近端（6'）和远端（6）矩形形成， 所述框架（3）由至少七个通过旋转接头（14,15,16,17,18,19,20）连接的连杆（7,8,9,10,11,12,13,22,23）形成， 26，27，109），其中a）所述近侧矩形（6'）的一对平行基座连接件（7,13）通过两个旋转接头（116,117）联接到所述基座（2）上，并被配置 基本上垂直于10操作表面（150）的平面并且围绕其与接头（116,117）的旋转轴线重合的纵向轴线旋转，由此b）所述旋转接头被配置为允许 六面体框架（3）自由地采用立方体，或由所述垂直耦合限制的平行六面体; 并且由此c）所述远侧矩形（6）通过传动装置（200）联接到所述仪器。

公开(公告)号：US20100215713A1

公开(公告)日：2010-08-26

申请号：US12681075

申请日：2008-09-30

申请人： Marie-Madeleine Dolmans-Van Der Vorst ,  Christiani Andrade Amorim ,  Anne Van Langendonckt ,  Jacques Donnez

发明人： Marie-Madeleine Dolmans-Van Der Vorst ,  Christiani Andrade Amorim ,  Anne Van Langendonckt ,  Jacques Donnez

IPC分类号： A61F2/00 ,  A61K38/22 ,  A61K38/28 ,  A61K38/43 ,  A61K31/34 ,  A61K31/355 ,  A61K31/522 ,  A61K38/20 ,  A61P15/08

CPC分类号： A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/414 ,  A61L2300/428 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/624

摘要： The present invention provides for a device comprising a scaffold composition, a bioactive composition and a bio-in-hibiting composition, wherein said bioactive and bio-inhibiting compositions are incorporated into or coated onto said scaffold composition, wherein said scaffold composition temporally supports survival and growth of resident follicles, migration and multiplication of stroma cells and spreading and organization of endothelial cells and new vessels wherein said bioactive composition regulates development of a resident follicle, formation of new blood vessels and chemoattraction and proliferation of stroma cells and wherein the bio-inhibiting composition regulates inhibition of the development of a second resident follicle. The presence of the bio-inhibiting composition within the scaffold is involved in the quiescence of the follicles in the primordial stage, which is important to restore fertility.

摘要翻译： 本发明提供了一种包含支架组合物，生物活性组合物和生物吸收组合物的装置，其中所述生物活性和生物抑制组合物掺入或涂覆到所述支架组合物上，其中所述支架组合物暂时支持存活和 居民卵泡的生长，基质细胞的迁移和增殖以及内皮细胞和新血管的扩散和组织，其中所述生物活性组合物调节居民卵泡的形成，新血管的形成和基质细胞的化学吸收和增殖，并且其中生物抑制 组成调节抑制第二次居民卵泡的发育。 支架内生物抑制组合物的存在参与原始阶段卵泡的静止，这对于恢复生育是重要的。

公开(公告)号：US08475469B2

公开(公告)日：2013-07-02

申请号：US12271466

申请日：2008-11-14

申请人： Christian Walter ,  Jacques Donnez

发明人： Christian Walter ,  Jacques Donnez

IPC分类号： A61B17/42

CPC分类号： A61B17/4241

摘要： A medical instrument has a rod-shaped body which has a distal end section which can be inserted through a vagina into an uterus. A bell-shaped element is mounted on the rod-shaped body. The bell-shaped element being slidingly displaceable along said rod-shaped body at least between an axial position on said rod-shaped body close to a proximal end thereof and up to said distal end section inserted in an uterus.

摘要翻译： 医疗器械具有杆状体，其具有能够通过阴道插入子宫的远端部。 钟形元件安装在杆状体上。 所述钟形元件至少在所述杆状体上的轴向位置之间至少位于所述棒状本体的近端，并且直到所述插入子宫内的所述远端部分沿所述杆状体滑动移动。

公开(公告)号：US5449354A

公开(公告)日：1995-09-12

申请号：US162926

申请日：1993-12-08

申请人： Ellie Konwitz ,  Jacques Donnez

发明人： Ellie Konwitz ,  Jacques Donnez

IPC分类号： A61B17/42 ,  A61B18/22 ,  A61B18/24 ,  A61B17/36

CPC分类号： A61B18/24 ,  A61B2017/4216 ,  A61B2018/2238

摘要： A device for treating the interior of a body cavity with laser energy includes a cannula having a distal end adapted to be inserted into the body cavity to be treated, and a proximal end to be located externally of the body cavity when the distal end is inserted therein, and an optical fiber axially movable within the cannula to either a retracted, non-operative position or to an extended, operative position. The optical fiber has a proximal end to be coupled to a source of laser energy, and a distal end to project outwardly of the cannula in the extended, operative position of the optical fiber. The distal end of the optical fiber has a roughened outer surface for scattering the laser energy laterally outwardly of the optical fiber.

摘要翻译： 用于用激光能量处理体腔内部的装置包括具有适于被插入待治疗的体腔中的远端的插管，以及当远端插入时位于体腔外部的近端 以及在套管内可轴向移动到缩回的非操作位置或延伸的操作位置的光纤。 光纤具有近端以与激光能量源耦合，并且远端在光纤的延伸的操作位置中向套管伸出的外端。 光纤的远端具有粗糙的外表面，用于在光纤横向向外散射激光能量。

公开(公告)号：USD628694S1

公开(公告)日：2010-12-07

申请号：US29350529

申请日：2009-11-18

申请人： Jacques Donnez

设计人： Jacques Donnez

公开(公告)号：US20090131954A1

公开(公告)日：2009-05-21

申请号：US12271466

申请日：2008-11-14

申请人： Walter Christian ,  Jacques Donnez

发明人： Walter Christian ,  Jacques Donnez

IPC分类号： A61B17/42

CPC分类号： A61B17/4241

摘要： A medical instrument has a rod-shaped body which has a distal end section which can be inserted through a vagina into an uterus. A bell-shaped element is mounted on the rod-shaped body. The bell-shaped element being slidingly displaceable along said rod-shaped body at least between an axial position on said rod-shaped body close to a proximal end thereof and up to said distal end section inserted in an uterus.

摘要翻译： 医疗器械具有杆状体，其具有能够通过阴道插入子宫的远端部。 钟形元件安装在杆状体上。 所述钟形元件至少在所述杆状体上的轴向位置之间至少位于所述棒状本体的近端，并且直到所述插入子宫内的所述远端部分沿所述杆状体滑动移动。

公开(公告)号：US5733279A

公开(公告)日：1998-03-31

申请号：US576487

申请日：1995-12-21

申请人： Ellie Konwitz ,  Jacques Donnez ,  Orit Frankel

发明人： Ellie Konwitz ,  Jacques Donnez ,  Orit Frankel

IPC分类号： A61B17/42 ,  A61B18/22 ,  A61B18/24 ,  A61B17/36

CPC分类号： A61B18/24 ,  A61B2017/4216 ,  A61B2018/2238 ,  A61B2090/036

摘要： A device for treating the interior of a body cavity with laser energy includes an optical fiber having a distal end to be inserted into the body cavity to be treated, and a proximal end to be located externally of the body cavity and to be coupled to a source of laser energy; a second fiber axially movable with respect to the optical fiber and mechanically coupled to its distal end to cause it to move in the lateral direction; and a stiffening spine normally supporting the distal ends of the two fibers in side-by-side relation, but permitting the distal end of one fiber to move laterally with respect to the other fiber.

摘要翻译： 用于用激光能量处理体腔内部的装置包括具有待插入待处理的体腔中的远端的光纤，以及位于体腔外部的近端，并且连接至 激光能源; 相对于光纤可轴向移动的第二纤维，并且机械地联接到其远端以使其在横向方向上移动; 并且加强脊通常以并排关系支撑两根纤维的远端，但允许一根纤维的远端相对于另一纤维横向移动。