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公开(公告)号：US5750646A
公开(公告)日：1998-05-12
申请号：US408197
申请日：1995-03-22
摘要： A linear peptide which is an analog of a naturally occurring, biologically active peptide having an active site and a binding site responsible for the binding of the peptide to a receptor on a target cell, cleavage of a peptide bond in the active site to the naturally occurring peptide being unnecessary for in vivo biological activity, the analog having a non-peptide bond instead of a peptide bond between an amino acid of the active site and an adjacent amino acid, and having the same binding site as the naturally occurring peptide, so that the analog is capable of acting as a competitive inhibitor of the naturally occurring peptide by binding to the receptor and, by virtue of the non-peptide bond, failing to exhibit the in vivo activity of the naturally occurring peptide.
摘要翻译： 线性肽，其是具有活性位点的天然存在的生物活性肽的类似物，以及负责肽与靶细胞上的受体结合的结合位点，将活性位点中的肽键切割成天然 发生的肽对于体内生物活性是不必要的，该类似物具有非肽键而不是活性位点的氨基酸与相邻氨基酸之间的肽键，并且具有与天然存在的肽相同的结合位点，因此 该类似物能够通过结合受体而作为天然存在的肽的竞争性抑制剂，并且由于非肽键，不能显示出天然存在的肽的体内活性。
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公开(公告)号：US5663295A
公开(公告)日：1997-09-02
申请号：US352391
申请日：1994-12-08
IPC分类号： A61K38/00 , A61P25/00 , C07K5/02 , C07K5/027 , C07K5/065 , C07K5/087 , C07K5/107 , C07K7/06 , C07K14/575 , C07K14/655 , C07K7/00
CPC分类号： C07K7/06 , C07K5/0202 , C07K5/0205 , C07K5/0207 , C07K5/0812 , C07K5/1016 , A61K38/00
摘要： Opioid peptides including those of the formula ##STR1## in which A.sub.1 is the identifying group of an amino acid selected from 3,4-dihydroxyphenylalanine, 3,4-dimethoxyphenylalanine, azatyrosine, and 2,6-dimethyltyrosine; A.sub.2 is the identifying group of an amino acid selected from D-Ala and D-Arg; A.sub.3 is H, or the identifying group of an amino acid selected from of 3,4-dihydroxyphenylalanine and 3,4-dimethoxyphenylalanine, A.sub.4 is H, cyclohexylmethyl, the identifying group of an amino acid selected from 3,4-dihydroxyphenylalanine, 3,4-dimethoxyphenylalanine, Phe, and substituted Phe with its benzene ring substituted by halogen, NO.sub.2, OH, or CH.sub.3 ; A.sub.5 is the identifying group of a D- or L-amino acid selected from Leu, Nle, Lys, Met and Met(O), or is deleted together with R.sub.4 --CH attached thereto; each R.sub.1 and R.sub.2 is --H, --C(NH.sub.2).dbd.NH, or C.sub.1-12 alkyl; R.sub.3 is ##STR2## R.sub.4 is ##STR3## and R.sub.5 is --(CH.sub.2).sub.n+1 OH, ##STR4## wherein m is 0-6, n is 0-6, and X is H, C.sub.1-12 alkyl, C.sub.6-12 aryl, C.sub.7-18 aralkyl, C.sub.7-18 alkaryl, C.sub.7-18 alkayl, C.sub.6-17 pyridylalkyl, or C.sub.6-17 alkylpyridyl; provided that when one of R.sub.1 and R.sub.2 is --C(NH.sub.2).dbd.NH, the other must be H; or a pharmaceutically acceptable salt thereof.
摘要翻译： 阿片样肽包括式“IMAGE”的那些，其中A1是选自3,4-二羟基苯丙氨酸，3,4-二甲氧基苯丙氨酸，氨甲酰酪氨酸和2,6-二甲基酪氨酸的氨基酸的鉴定基团; A2是选自D-Ala和D-Arg的氨基酸的鉴定基团; A3是H，或选自3,4-二羟基苯丙氨酸和3,4-二甲氧基苯丙氨酸的氨基酸的鉴定基团，A4是H，环己基甲基，选自3,4-二羟基苯丙氨酸， 4-二甲氧基苯丙氨酸，Phe和取代的Phe，其苯环被卤素，NO 2，OH或CH 3取代; A5是选自Leu，Nle，Lys，Met和Met（O）的D-或L-氨基酸的鉴定基团，或与其连接的R4-CH一起缺失; 每个R 1和R 2是-H，-C（NH 2）= NH或C 1-12烷基; R3是
，R4是 ，R5是 - （CH2）n + 1OH，其中m是0-6，n是0-6，X是H，C1-12烷基，C6-12 芳基，C7-18芳烷基，C7-18烷芳基，C7-18烷基，C6-17吡啶基烷基或C6-17烷基吡啶基; 条件是当R 1和R 2中的一个是-C（NH 2）= NH时，另一个必须是H; 或其药学上可接受的盐。 -
公开(公告)号：US5073541A
公开(公告)日：1991-12-17
申请号：US231136
申请日：1988-08-11
IPC分类号： A61K38/04 , A61K38/00 , A61P35/00 , C07K14/655
CPC分类号： C07K14/6555 , A61K38/00
摘要： A method of treating a mammal suffering from cancer by administering to the mammal somatostatin or an analog thereof, the analog being a hexapeptide analog or higher, in a dosage of at least 25 .mu.g/kg/day.
摘要翻译： 通过以至少25μg/ kg /天的剂量向哺乳动物生长抑素或其类似物（类似物为六肽类似物或更高剂量）治疗患有癌症的哺乳动物的方法。
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公开(公告)号：US5162497A
公开(公告)日：1992-11-10
申请号：US282328
申请日：1988-12-09
IPC分类号： A61K38/00 , C07K7/02 , C07K7/08 , C07K7/18 , C07K14/575 , C07K14/685
CPC分类号： C07K7/086 , C07K14/57572 , C07K14/685 , C07K7/02 , C07K7/18 , A61K38/00 , Y10S514/803
摘要： A bradykinin analog which contains nine or ten amino acid residues and at least one [CH.sub.2 NH] pseudopeptide bond, the analog being useful as an antagonist or agonist of the naturally occuring bradykinin.
摘要翻译： 包含9或10个氨基酸残基和至少一个[CH 2 N H]假肽键的缓激肽类似物，该类似物可用作天然存在的缓激肽的拮抗剂或激动剂。
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公开(公告)号：US5708135A
公开(公告)日：1998-01-13
申请号：US578037
申请日：1995-12-26
申请人： David H. Coy , John E. Taylor
发明人： David H. Coy , John E. Taylor
IPC分类号： C07K7/02 , A61K38/00 , C07K20060101 , C07K7/00 , C07K14/655
CPC分类号： C07K14/6555 , A61K38/00 , Y10S930/16
摘要： A cyclic peptide analog of somatostatin wherein a disulfide bond links the N-terminus residue and the C-terminus residue.
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公开(公告)号：US4699461A
公开(公告)日：1987-10-13
申请号：US711248
申请日：1985-03-13
申请人： John E. Taylor , Ian W. Keene
发明人： John E. Taylor , Ian W. Keene
CPC分类号： G02B6/4422 , G02B6/4403 , G02B6/4407 , H01B5/108 , D07B1/147
摘要： An overhead electric conductor comprises a central tubular metal core, at least one layer of helically wound bare metal wires surrounding the core and, loosely housed in the bore of the core, at least one optical fibre element. The optical fibre element comprises a flexible tube of elongate transverse cross-section in which is loosely housed an optical fibre ribbon structure and which is resiliently set in such a form that it follows a path of smoothly curved undulations, the axes of curvature of which lie parallel to one another and normal to the axis of the tube. Should a tensile force applied to the overhead conductor be transferred to the loosely housed optical fibre element, the flexible tube of the element will tend to straighten in a lengthwise direction against the action of its resilient set thereby to reduce any tensile force that might otherwise be applied to the optical fibres and, when the tensile force is removed, the tube will return under the action of its resilient set towards its original form.
摘要翻译： 架空电导体包括中心管状金属芯，围绕芯的至少一层螺旋缠绕的裸金属线，并松散地容纳在芯的孔中，至少一个光纤元件。 光纤元件包括细长横截面的柔性管，其中松散地容纳光纤带结构，并且弹性地设置成使得其遵循平滑弯曲的起伏的路径，其曲率轴线位于 彼此平行并垂直于管轴。 如果施加到架空导体的拉力传递到松散收容的光纤元件，则该元件的柔性管将倾向于抵抗其弹性组的作用沿长度方向拉直，从而减小否则可能的任何张力 应用于光纤，并且当拉力被去除时，管将在其弹性组件的作用下返回到其原始形式。
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公开(公告)号：US08641519B2
公开(公告)日：2014-02-04
申请号：US13482446
申请日：2012-05-29
申请人： Mark E. Herrmann , Dow K. Hardy , John F. Acres , John E. Taylor , Scott N. Weller , Francis Josef Lichtenberger
发明人： Mark E. Herrmann , Dow K. Hardy , John F. Acres , John E. Taylor , Scott N. Weller , Francis Josef Lichtenberger
CPC分类号： A63F9/24 , G06F17/00 , G06Q30/02 , G07F17/32 , G07F17/3237
摘要： A distributed computer system is provided for collecting player information. Further, a scoring system is provided that rates a player based on one or more elements of the collected information. Players may be rated with respect to a number of characteristics. Responsive to a determined rating or score, action may be taken by the distributed system with regard to the player. For instance, the player may be provided a complimentary offer, provided an award, and invitation to come to a gambling location, presented an advertisement, or other action may be performed involving the player. Further, the distributed computer system may permit a player to manage their frequent player accounts and receive complimentary offers based on a set of criteria specified by the player.
摘要翻译： 提供分布式计算机系统来收集玩家信息。 此外，提供了一种评分系统，其基于收集的信息的一个或多个元素对玩家进行评分。 玩家可能会根据一些特征进行评级。 响应于确定的评分或分数，分配系统可以针对玩家采取行动。 例如，可以向玩家提供免费优惠，提供奖励，邀请来到赌博场所，呈现广告，或者可以涉及玩家的其他动作。 此外，分布式计算机系统可以允许玩家根据玩家指定的一套标准来管理他们的频繁的玩家帐户并接收免费优惠。
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公开(公告)号：US20090191962A1
公开(公告)日：2009-07-30
申请号：US12238849
申请日：2008-09-26
IPC分类号： A63F9/24
CPC分类号： G07F17/3244 , G07F17/32 , G07F17/3225 , G07F17/3237 , G07F17/3239 , G07F17/3255
摘要： A system and method is provided for incentivizing players to visit a gambling location. In one aspect, a qualified person is invited to play an electronic game which has a plurality of outcomes, at least one of which is a winning outcome. In one embodiment, the qualified person may be required to redeem the outcome at the gambling location. In another embodiment, the person may be required to redeem the outcome at a redemption location. In another aspect, a method is provided for permitting a person to take one or more actions within a gambling location and in response inviting the person to play an electronic game separate from the games offered in a gambling environment at the gambling location, where the game has a plurality of outcomes, at least one of which is a winning outcome, and if the person obtains a winning outcome, requiring the person to redeem the at least one outcome at the gambling location. In one embodiment, the method includes the acts of qualifying a person. Qualification may require specific acts, for example, referring another person, and/or providing an invitation to play an electronic game to another person. Various systems and method assist in tracking and maintaining such referrals. Additionally group gaming in and amongst referrals and/or designated groups may be performed, and in some embodiment required for qualification and/or redemption. Further, another aspect relates to providing special incentives, for example for referral of a new player, for providing casino affiliation or membership information, among others.
摘要翻译： 提供了一种系统和方法，用于激励玩家访问赌博场所。 一方面，合格的人被邀请玩具有多个结果的电子游戏，其中至少一个是获胜结果。 在一个实施例中，可能需要合格的人员在赌博地点兑换结果。 在另一个实施例中，该人可能被要求在兑换地点兑换结果。 在另一方面，提供了一种允许一个人在赌博位置内采取一个或多个动作的方法，并且作为响应邀请该人与在赌博地点的赌博环境中提供的游戏分开玩一个电子游戏，其中该游戏 具有多个结果，其中至少一个是获胜结果，并且如果该人获得获胜结果，则要求该人在该赌博地点兑换该至少一个结果。 在一个实施例中，该方法包括限定人员的行为。 资格可能需要特定的行为，例如引用另一个人，和/或提供向另一个人玩电子游戏的邀请。 各种系统和方法有助于跟踪和维护这种转介。 此外，可以执行在转介和/或指定群组内和之间的组游戏，并且在某些实施例中需要资格和/或兑换。 此外，另一方面涉及提供特别的激励，例如用于转介新玩家，用于提供赌场附属或会员信息等。
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公开(公告)号：US20080146345A1
公开(公告)日：2008-06-19
申请号：US11840262
申请日：2007-08-17
IPC分类号： G06F17/00
CPC分类号： G07F17/32 , G07F17/3239 , G07F17/3255 , G07F17/329
摘要： A system and method is provided for incentivizing players to visit a gambling location. In one aspect, a qualified person is invited to play an electronic game which has a plurality of outcomes, at least one of which is a winning outcome. In one embodiment, the qualified person may be required to redeem the outcome at the gambling location. In another embodiment, the person may be required to redeem the outcome at a redemption location. In another aspect, a method is provided for permitting a person to take one or more actions within a gambling location and in response inviting the person to play an electronic game separate from the games offered in a gambling environment at the gambling location, where the game has a plurality of outcomes, at least one of which is a winning outcome, and if the person obtains a winning outcome, requiring the person to redeem the at least one outcome at the gambling location. In one embodiment, the method includes the acts of qualifying a person, and in response to the act of qualifying the person, performing acts of providing an award to the qualified person and inviting the person to visit a gambling location to redeem the award. A method is provided for incentivizing players to return to a gambling location after a previous visit. One aspect relates to a method for providing additional incentives to a frequent player program member to visit a gambling location such as a casino. In one example, the ease of using the Internet or other remote technologies is combined with advantages of a frequent player program to encourage players to return to the casino. A prize may be revealed in an online game, and the prize may need to be redeemed at the location of the casino. In one example game format, the player may be provided game credits to a player to play one or more online games that reveal prizes. The prizes may include, for example, an amount of non-cashable credit that may be used by the player to play one or more games located at the gambling location, thus encouraging player return. Other prizes, such as, for example, complimentary offers and/or promotional prizes may be awarded that can only be redeemed by the player by returning to the gambling location. Further, another aspect relates to providing special incentives for remote entry of casino affiliation or membership cards. The special incentives may include providing a prize or award to frequent player program members that remotely use his or her membership. In one example, the player is provided an indication of winning an incentive during play of an online game. In another example, the player may be required to obtain the winnings at the casino to encourage players to return to the casino.
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公开(公告)号：US20080146323A1
公开(公告)日：2008-06-19
申请号：US11841728
申请日：2007-08-20
IPC分类号： A63F9/24
CPC分类号： G07F17/32 , G07F17/3239 , G07F17/3255
摘要： A system and method is provided for incentivizing players to visit a gambling location. In one aspect, a qualified person is invited to play an electronic game which has a plurality of outcomes, at least one of which is a winning outcome. In one embodiment, the qualified person may be required to redeem the outcome at the gambling location. In another embodiment, the person may be required to redeem the outcome at a redemption location. In another aspect, a method is provided for permitting a person to take one or more actions within a gambling location and in response inviting the person to play an electronic game separate from the games offered in a gambling environment at the gambling location, where the game has a plurality of outcomes, at least one of which is a winning outcome, and if the person obtains a winning outcome, requiring the person to redeem the at least one outcome at the gambling location. In one embodiment, the method includes the acts of qualifying a person, and in response to the act of qualifying the person, performing acts of providing an award to the qualified person and inviting the person to visit a gambling location to redeem the award. A method is provided for incentivizing players to return to a gambling location after a previous visit. One aspect relates to a method for providing additional incentives to a frequent player program member to visit a gambling location such as a casino. In one example, the ease of using the Internet or other remote technologies is combined with advantages of a frequent player program to encourage players to return to the casino. A prize may be revealed in an online game, and the prize may need to be redeemed at the location of the casino. In one example game format, the player may be provided game credits to a player to play one or more online games that reveal prizes. The prizes may include, for example, an amount of non-cashable credit that may be used by the player to play one or more games located at the gambling location, thus encouraging player return. Other prizes, such as, for example, complimentary offers and/or promotional prizes may be awarded that can only be redeemed by the player by returning to the gambling location. Further, another aspect relates to providing special incentives for remote entry of casino affiliation or membership cards. The special incentives may include providing a prize or award to frequent player program members that remotely use his or her membership. In one example, the player is provided an indication of winning an incentive during play of an online game. In another example, the player may be required to obtain the winnings at the casino to encourage players to return to the casino.
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