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公开(公告)号：US08697703B2
公开(公告)日：2014-04-15
申请号：US13521680
申请日：2011-01-14
IPC分类号： A61K31/495
CPC分类号： C07D401/06 , A61K31/496 , C07D215/48 , C07D217/26 , C07D251/48
摘要： The present invention relates to novel piperazine compounds; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial and to treat diseases for which blocking the Cav2.2 and Cav3.2 calcium channels is beneficial, e.g. to treat pain.
摘要翻译： 本发明涉及新型哌嗪化合物; 包含该化合物的药物组合物; 以及在治疗中使用化合物治疗阻断Cav2.2钙通道有益的疾病并治疗阻断Cav2.2和Cav3.2钙通道的疾病是有益的。 治疗疼痛。
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公开(公告)号：US20130072499A1
公开(公告)日：2013-03-21
申请号：US13521680
申请日：2011-01-14
IPC分类号： A61K31/496 , A61P29/00 , C07D401/10 , A61P25/06
CPC分类号： C07D401/06 , A61K31/496 , C07D215/48 , C07D217/26 , C07D251/48
摘要： The present invention relates to novel piperazine compounds; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial and to treat diseases for which blocking the Cav2.2 and Cav3.2 calcium channels is beneficial, e.g. to treat pain.
摘要翻译： 本发明涉及新型哌嗪化合物; 含有该化合物的药物组合物; 以及在治疗中使用化合物治疗阻断Cav2.2钙通道有益的疾病并治疗阻断Cav2.2和Cav3.2钙通道的疾病是有益的。 治疗疼痛。
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公开(公告)号：US08530478B2
公开(公告)日：2013-09-10
申请号：US13054265
申请日：2009-07-15
申请人： Paul John Beswick , Alister Campbell , Andrew Peter Cridland , Robert James Gleave , Jag Paul Heer , Neville Hubert Nicholson , Lee William Page , Sadie Vile
发明人： Paul John Beswick , Alister Campbell , Andrew Peter Cridland , Robert James Gleave , Jag Paul Heer , Neville Hubert Nicholson , Lee William Page , Sadie Vile
IPC分类号： A61K31/496 , C07D401/06
CPC分类号： C07D213/81
摘要： The present invention relates to novel piperazine derivatives (I); to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.
摘要翻译： 本发明涉及新型哌嗪衍生物（I）; 进行准备; 含有该衍生物的药物组合物; 以及在治疗中使用衍生物治疗阻断Cav2.2钙通道有益的疾病。
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公开(公告)号：US20110130379A1
公开(公告)日：2011-06-02
申请号：US13054265
申请日：2009-07-15
申请人： Paul John Beswick , Alister Campbell , Andrew Peter Cridland , Robert James Gleave , Jag Paul Heer , Neville Hubert Nicholson , Lee William Page , Sadie Vile
发明人： Paul John Beswick , Alister Campbell , Andrew Peter Cridland , Robert James Gleave , Jag Paul Heer , Neville Hubert Nicholson , Lee William Page , Sadie Vile
IPC分类号： A61K31/496 , C07D401/06 , A61P25/00 , C07D401/14
CPC分类号： C07D213/81
摘要： The present invention relates to novel piperazine derivatives (I); to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.
摘要翻译： 本发明涉及新型哌嗪衍生物（I）; 进行准备; 含有该衍生物的药物组合物; 以及在治疗中使用衍生物治疗阻断Cav2.2钙通道有益的疾病。
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![Pyrazolo[1,5-A]pyrimidine-carbonyl-piperazine derivatives](/abs-image/US/2012/01/10/US08093249B2/abs.jpg.150x150.jpg)
公开(公告)号：US08093249B2
公开(公告)日：2012-01-10
申请号：US12503135
申请日：2009-07-15
申请人： Jag Paul Heer , David Norton , Simon E Ward
发明人： Jag Paul Heer , David Norton , Simon E Ward
IPC分类号： A61K31/497 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel piperazine derivatives; to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.
摘要翻译： 本发明涉及新的哌嗪衍生物; 进行准备; 含有该衍生物的药物组合物; 以及在治疗中使用衍生物治疗阻断Cav2.2钙通道有益的疾病。
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公开(公告)号：US20100016330A1
公开(公告)日：2010-01-21
申请号：US12503135
申请日：2009-07-15
申请人： Jag Paul Heer , David Norton , Simon E. Ward
发明人： Jag Paul Heer , David Norton , Simon E. Ward
IPC分类号： A61K31/496 , C07D487/04 , A61P29/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel piperazine derivatives; to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.
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公开(公告)号：US08329730B2
公开(公告)日：2012-12-11
申请号：US12989700
申请日：2009-04-29
IPC分类号： C07D413/04 , A61K31/4725
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译： 本发明涉及具有药理活性的新型恶二唑衍生物，其制备方法，含有它们的药物组合物及其在治疗各种病症中的用途。
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公开(公告)号：US08222245B2
公开(公告)日：2012-07-17
申请号：US12747205
申请日：2008-12-19
申请人： Emmanuel Hubert Demont , Jag Paul Heer , John Skidmore , Ian David Wall , Jason Witherington , Thomas Daniel Heightman , David Nigel Hurst , Christopher Norbert Johnson
发明人： Emmanuel Hubert Demont , Jag Paul Heer , John Skidmore , Ian David Wall , Jason Witherington , Thomas Daniel Heightman , David Nigel Hurst , Christopher Norbert Johnson
IPC分类号： A61P17/00 , A61P37/00 , A61K31/55 , C07D223/16 , C07D267/14 , C07D271/06 , C07D413/04 , C07D413/14
CPC分类号： C07D223/16 , C07D267/14 , C07D271/06 , C07D413/04 , C07D413/14
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译： 本发明涉及具有药理活性的新型恶二唑衍生物，其制备方法，含有它们的药物组合物及其在治疗各种病症中的用途。
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公开(公告)号：US08288388B2
公开(公告)日：2012-10-16
申请号：US12503125
申请日：2009-07-15
申请人： Paul John Beswick , Alister Campbell , Andrew Cridland , Robert James Gleave , Jag Paul Heer , Neville Hubert Nicholson , Lee William Page , Sadie Vile
发明人： Paul John Beswick , Alister Campbell , Andrew Cridland , Robert James Gleave , Jag Paul Heer , Neville Hubert Nicholson , Lee William Page , Sadie Vile
IPC分类号： A61K31/496 , C07D401/06
CPC分类号： C07D213/81
摘要： The present invention relates to novel piperazine derivatives; to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial.
摘要翻译： 本发明涉及新的哌嗪衍生物; 进行准备; 含有该衍生物的药物组合物; 以及在治疗中使用衍生物治疗阻断Cav2.2钙通道有益的疾病。
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公开(公告)号：US08278324B2
公开(公告)日：2012-10-02
申请号：US12747191
申请日：2008-12-19
IPC分类号： C07D413/04 , A61K31/4725
CPC分类号： C07D217/06 , C07D217/16 , C07D217/22 , C07D413/04
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
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