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1.发明授权
公开(公告)号：US5268129A
公开(公告)日：1993-12-07
申请号：US878645
申请日：1992-05-05
CPC分类号： A61K51/1217 , A61K2121/00 , A61K2123/00
摘要： A stabilized radionuclide-colloid composition useful in therapeutic radiation ablation therapies is disclosed. The composition contains a viscosity modifier layered mixed metal hydroxide and optionally an ion exchange medium to stabilize the radioactive colloid.
摘要翻译： 公开了一种稳定的放射性核素 - 胶体组合物，用于治疗放射线消融治疗。 组合物含有粘度调节剂层状混合金属氢氧化物和任选的离子交换介质以稳定放射性胶体。
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2.发明授权Layered mixed metal hydroxides for the stabilization of radioactive colloids 失效层状混合金属氢氧化物用于放射性胶体的稳定化
公开(公告)号：US5137709A
公开(公告)日：1992-08-11
申请号：US656397
申请日：1991-02-15
CPC分类号： A61K51/1217 , A61K2121/00 , A61K2123/00
摘要： A stabilized radionuclide-colloid composition useful in therapeutic radiation ablation therapies is disclosed. The composition contains a viscosity modifier layered mixed metal hydroxide and optionally an ion exchange medium to stabilize the radioactive colloid.
摘要翻译： 公开了一种稳定的放射性核素 - 胶体组合物，用于治疗性放射线消融治疗。 组合物含有粘度调节剂层状混合金属氢氧化物和任选的离子交换介质以稳定放射性胶体。
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3.发明授权
公开(公告)号：US5435990A
公开(公告)日：1995-07-25
申请号：US962168
申请日：1992-10-15
申请人： Roberta C. Cheng , William A. Fordyce , William F. Goeckleler , William J. Kruper, Jr. , Richard K. Frank , Joseph R. Garlich , Garry E. Kiefer , Kenneth McMillan , Jaime Simon , David A. Wilson , Sharon Braughman
发明人： Roberta C. Cheng , William A. Fordyce , William F. Goeckleler , William J. Kruper, Jr. , Richard K. Frank , Joseph R. Garlich , Garry E. Kiefer , Kenneth McMillan , Jaime Simon , David A. Wilson , Sharon Braughman
IPC分类号： A61K9/08 , A61K9/107 , A61K31/395 , A61K39/395 , A61K51/00 , A61K51/04 , A61K51/10 , A61P35/00 , C07D257/02 , C07K16/00 , A61M36/06 , C07K16/30
CPC分类号： C07D257/02 , A61K51/0482 , A61K51/1045 , A61K51/109 , A61K2121/00 , A61K2123/00
摘要： A group of functionalized macrocyclic polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes for cancer.
摘要翻译： 公开了与稀土类金属离子形成络合物的一组官能化的大环多胺羧酸盐螯合剂。 与抗体或抗体片段共价连接的复合物可用于癌症的治疗和/或诊断目的。
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公开(公告)号：US4976950A
公开(公告)日：1990-12-11
申请号：US435096
申请日：1989-11-13
IPC分类号： A61K51/04
CPC分类号： A61K51/0482 , A61K2121/00
摘要： The invention concerns a method for suppressing bone marrow which comprises administering to a mammal at least one bone marrow suppressing complex of a radionuclide selected from the group consisting of Samarium-153, Gadolinium-159, Holmium-166 and Yttrium-90 and at least one macrocyclic aminophosphonic acid ligand containing the 1,4,7,10-tetraazacyclododecane moiety, or a physiologically acceptable salt thereof. Suitable compositions for use in this method are also provided.
摘要翻译： 本发明涉及一种抑制骨髓的方法，其包括向哺乳动物施用选自钐-153，钆-159，钬-166和钇-90的至少一种放射性核素的骨髓抑制复合物和至少一种 含有1,4,7,10-四氮杂环十二烷部分的大环氨基膦酸配体或其生理上可接受的盐。 还提供了用于该方法的合适的组合物。
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公开(公告)号：US5714631A
公开(公告)日：1998-02-03
申请号：US597335
申请日：1996-02-06
IPC分类号： A61K51/04 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/00 , G01N33/534 , C07C229/00
CPC分类号： G01N33/534 , A61K51/0478 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/003 , A61K2121/00 , A61K2123/00
摘要： A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
摘要翻译： 公开了一组具有与稀土类金属离子形成络合物的邻位官能团的官能化胺螯合剂。 复合物可以共价连接到抗体或抗体片段上并用于治疗和/或诊断目的。 此外，某些螯合剂 - 放射性核素复合物可以有效地用于可用作钙化肿瘤的治疗和/或诊断剂和/或缓解骨痛的组合物中。
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公开(公告)号：US4882142A
公开(公告)日：1989-11-21
申请号：US284875
申请日：1988-12-19
IPC分类号： A61K31/675 , A61K51/00 , A61K51/04 , A61P7/00
CPC分类号： A61K51/0489 , A61K51/0482 , A61K2121/00
摘要： The invention concerns a method for suppressing bone marrow which comprises administering to a mammal at least one bone marrow suppressing complex of a radionuclide selected from the group consisting of Samarium-153, Gadolinium-159, and Holmium-166 and 1,4,7,10-tetraazacyclododecanetetramethylenephosphonic acid a physiologically acceptable salt thereof. Suitable compositions for use in this method are also provided.
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公开(公告)号：US5342604A
公开(公告)日：1994-08-30
申请号：US900808
申请日：1992-06-17
IPC分类号： A61K51/04 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/00 , G01N33/534 , A61K43/00 , A61K49/02 , C07F3/00
CPC分类号： G01N33/534 , A61K51/0478 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/003 , A61K2121/00 , A61K2123/00
摘要： A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The chelants possess the general formula ##STR1## wherein R.sup.'1, R.sup.'2, R.sup.'3, R.sup.'4, R.sup.'5 and R.sup.'6, Z' and X are all defined in the specification. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
摘要翻译： 公开了一组具有与稀土类金属离子形成络合物的邻位官能团的官能化胺螯合剂。 螯合剂具有通式III，其中R'1，R'2，R'3，R'4，R'5和R'6，Z'和X均在本说明书中定义。 此外，某些螯合剂 - 放射性核素复合物可以有效地用于可用作钙化肿瘤的治疗和/或诊断剂和/或缓解骨痛的组合物中。
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8.发明授权Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents 失效大环四氮环十二烷共轭物及其作为诊断和治疗剂的用途
公开(公告)号：US5756065A
公开(公告)日：1998-05-26
申请号：US389836
申请日：1995-02-15
申请人： David A. Wilson , Joseph R. Garlich , William A. Fordyce , R. Keith Frank , Jaime Simon , William F. Goeckler , Roberta C. Cheng , William J. Kruper , Kenneth McMillan
发明人： David A. Wilson , Joseph R. Garlich , William A. Fordyce , R. Keith Frank , Jaime Simon , William F. Goeckler , Roberta C. Cheng , William J. Kruper , Kenneth McMillan
CPC分类号： A61K51/0482
摘要： A group conjugates having a functionalized polyaminocarboxylate chelant that form complexes with rare earth-type metal ions, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.
摘要翻译： 具有与共价键连接到抗体或抗体片段的与稀土类金属离子形成复合物的官能化聚氨基羧酸盐螯合剂的基团缀合物可用于治疗和/或诊断目的。
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公开(公告)号：US5652361A
公开(公告)日：1997-07-29
申请号：US028050
申请日：1993-03-08
申请人： Jaime Simon , Joseph R. Garlich , Garry E. Kiefer , Kenneth McMillan , Richard Keith Frank , William F. Goeckeler , William A. Fordyce , Roberta C. Cheng , William J. Kruper, Jr. , Sharon Baughman , David A. Wilson
发明人： Jaime Simon , Joseph R. Garlich , Garry E. Kiefer , Kenneth McMillan , Richard Keith Frank , William F. Goeckeler , William A. Fordyce , Roberta C. Cheng , William J. Kruper, Jr. , Sharon Baughman , David A. Wilson
IPC分类号： A61K20060101 , A61K31/395 , A61K39/44 , A61K47/00 , A61K49/00 , A61K51/00 , A61K51/04 , A61K51/10 , A61M36/06 , C07D20060101 , C07D257/02 , C07D259/00 , C07K16/30 , G01N20060101 , G01N33/53 , G01N33/534 , C07F15/00
CPC分类号： A61K51/0482 , A61K31/395 , A61K51/1045 , A61K51/109 , C07D257/02 , A61K2121/00
摘要： A group of functionalized polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/or diagnostic purposes.
摘要翻译： 公开了与稀土类金属离子形成络合物的一组官能化的聚氨基羧酸盐螯合剂。 与抗体或抗体片段共价连接的复合物可用于治疗和/或诊断目的。
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公开(公告)号：US5061476A
公开(公告)日：1991-10-29
申请号：US458049
申请日：1989-12-27
CPC分类号： A61K51/1217 , A61K2121/00
摘要： Radiolabeled colloid compositions and a method for the preparation of radionuclide-colloid compositions useful in the treatment of rheumatoid arthritis are disclosed. A radionuclide selected from the group consisting of Sm-135, Ho-166, In-155m, Y-90, Gd-159 La-140, Lu-177, or Yb-175 is sorbed to a previously prepared iron-hydroxide colloid. The radiolabeled colloid compositions are comprised of spherical aggregations containing greater than 50% of the radioactive metal in iron-hydroxide particles. The method produces stable radionuclide iron-hydroxide compositions which are useful in therapeutic procedures such as radiation synovectomy.
摘要翻译： 公开了放射性标记的胶体组合物和制备用于治疗类风湿性关节炎的放射性核素 - 胶体组合物的方法。 选自Sm-135，Ho-166，In-155m，Y-90，Gd-159 La-140，Lu-177或Yb-175的放射性核素吸附到预先制备的氢氧化铁胶体上。 放射性标记的胶体组合物由含有大于50％的氢氧化铁颗粒中的放射性金属的球形聚集体组成。 该方法产生稳定的放射性核素氢氧化铁组合物，其可用于诸如放射性滑膜切除术的治疗程序。
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