-
公开(公告)号:US20100256157A1
公开(公告)日:2010-10-07
申请号:US12727488
申请日:2010-03-19
申请人: Jakob Busch-Petersen , Thomas B. LEONARD , Michael R. Palovich , Henry M. Sarau , Aili L. Lazaar , Katherine L. Widdowson
发明人: Jakob Busch-Petersen , Thomas B. LEONARD , Michael R. Palovich , Henry M. Sarau , Aili L. Lazaar , Katherine L. Widdowson
IPC分类号: A61K31/495 , A61P1/18 , A61P11/00
CPC分类号: C07D295/26
摘要: This invention relates to the use of a sulfonamide substituted diphenyl urea compound to treat cystic fibrosis, or the symptoms associated with cystic fibrosis.
摘要翻译: 本发明涉及磺酰胺取代的二苯基脲化合物治疗囊性纤维化或与囊性纤维化有关的症状的用途。
-
公开(公告)号:US07709485B2
公开(公告)日:2010-05-04
申请号:US11869055
申请日:2007-10-09
IPC分类号: A61K31/495 , C07D295/26
CPC分类号: C07D295/26
摘要: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
摘要翻译: 本发明涉及式(I)至(VII)的新化合物及其组合物,其可用于治疗由趋化因子介导的疾病状态,白细胞介素-8(IL-8)。
-
公开(公告)号:US20090093492A1
公开(公告)日:2009-04-09
申请号:US11869055
申请日:2007-10-09
IPC分类号: A61K31/495 , C07D295/26
CPC分类号: C07D295/26
摘要: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
摘要翻译: 本发明涉及式(I)至(VII)的新化合物及其组合物,其可用于治疗由趋化因子介导的疾病状态,白细胞介素-8(IL-8)。
-
公开(公告)号:US07579345B2
公开(公告)日:2009-08-25
申请号:US11568909
申请日:2005-05-26
IPC分类号: C07D498/08 , A61K31/537
CPC分类号: C07D498/08
摘要: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
-
公开(公告)号:US20080275079A1
公开(公告)日:2008-11-06
申请号:US11997466
申请日:2006-08-02
申请人: Jakob Busch-Petersen , Dramane Ibrahim Laine , Michael R. Palovich , Roderick S. Davis , Wei Fu , Haibo Xie
发明人: Jakob Busch-Petersen , Dramane Ibrahim Laine , Michael R. Palovich , Roderick S. Davis , Wei Fu , Haibo Xie
IPC分类号: A61K31/437 , C07D451/02 , A61P17/00
CPC分类号: C07D451/02
摘要: Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
摘要翻译: 提供毒蕈碱性乙酰胆碱受体拮抗剂及其使用方法。
-
公开(公告)号:US07276521B2
公开(公告)日:2007-10-02
申请号:US10575839
申请日:2004-10-12
IPC分类号: A01N43/42 , A61K31/44 , C07D451/02 , C07D401/00 , C07D405/00
CPC分类号: A61K31/46 , C07D451/02
摘要: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
-
公开(公告)号:US07384946B2
公开(公告)日:2008-06-10
申请号:US10598882
申请日:2004-03-17
申请人: Jakob Busch-Petersen , Anthony W. J. Cooper , Dramane I. Laine , Brent W. McCleland , Michael R. Palovich
发明人: Jakob Busch-Petersen , Anthony W. J. Cooper , Dramane I. Laine , Brent W. McCleland , Michael R. Palovich
IPC分类号: C07D487/08 , C07D401/14 , C07D403/14 , A61K31/403 , A61K31/497 , A61K31/4439
CPC分类号: C07D519/00
摘要: Novel dimeric benzoazabicyclohepatane compounds, pharmaceutical compositions, processes for their preparation and use thereof in treating M3 muscarinic acetylcholine receptor mediated diseases are disclosed.
摘要翻译: 公开了新型二聚苯并氮杂双环磷烷化合物,药物组合物,其制备方法及其在治疗M 3毒蕈碱性乙酰胆碱受体介导的疾病中的用途。
-
公开(公告)号:US07232841B2
公开(公告)日:2007-06-19
申请号:US10552492
申请日:2004-04-07
IPC分类号: A61K31/403 , C07D209/56
CPC分类号: C07D519/00 , C07D487/08
摘要: Novel thiazole aniline compounds, pharmaceutical compositions, methods of making them and uses thereof in treating M3 muscarinic acetylcholine receptor mediated diseases are disclosed.
-
公开(公告)号:US20120142668A1
公开(公告)日:2012-06-07
申请号:US13389631
申请日:2010-08-11
申请人: Niall Anderson , Ann M. Bullion , Neysa Nevins , Michael R. Palovich , Steven L. Sollis , Michael D. Wall , Jakob Busch-Petersen , Brian Evans , Huijie Li
发明人: Niall Anderson , Ann M. Bullion , Neysa Nevins , Michael R. Palovich , Steven L. Sollis , Michael D. Wall , Jakob Busch-Petersen , Brian Evans , Huijie Li
IPC分类号: A61K31/397 , C07D211/60 , C07C229/38 , C07D277/46 , C07D209/08 , C07D213/75 , C07D231/40 , C07D401/12 , C07D417/12 , A61K31/165 , A61K31/4453 , A61K31/24 , A61K31/404 , A61K31/4406 , A61K31/415 , A61K31/4468 , A61P11/00 , A61K31/426 , A61K31/454 , C07C237/20
CPC分类号: C07C237/22 , C07B2200/07 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D205/04 , C07D209/14 , C07D209/44 , C07D211/56 , C07D211/58 , C07D213/75 , C07D231/40 , C07D277/46 , C07D285/135 , C07D295/185 , C07D307/22 , C07D309/14 , C07D333/24 , C07D333/36 , C07D401/12 , C07D403/12 , C07D417/12
摘要: Disclosed are 4-amino-2-butenamides of Formula (I) having pharmacological activity, pharmaceutical compositions containing them, and methods for the treatment of diseases mediated by the cathepsin C enzyme such as chronic obstructive pulmonary disease.
摘要翻译: 公开了具有药理活性的式(I)的4-氨基-2-丁烯酰胺,含有它们的药物组合物和用于治疗组织蛋白酶C酶介导的疾病如慢性阻塞性肺病的方法。
-
公开(公告)号:US07579361B2
公开(公告)日:2009-08-25
申请号:US11766318
申请日:2007-06-21
IPC分类号: A01N43/42 , A61K31/44 , C07D451/02
CPC分类号: A61K31/46 , C07D451/02
摘要: Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
-
-
-
-
-
-
-
-
-