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公开(公告)号：US20080234315A1
公开(公告)日：2008-09-25
申请号：US11997451
申请日：2006-08-02
申请人： Jakob Busch-Petersen , Dramane Ibrahim Laine , Michael R. Palovich , Roderick S. Davis , Wei Fu , Haibo Xie
发明人： Jakob Busch-Petersen , Dramane Ibrahim Laine , Michael R. Palovich , Roderick S. Davis , Wei Fu , Haibo Xie
IPC分类号： A61K31/435 , C07D451/02 , A61P17/00
CPC分类号： C07D451/02
摘要： The present invention is directed to novel Muscarinic Acetylcholine receptor antagonists of Formula (I), pharmaceutical compositions and methods of using them. Compounds of Formula (I) are, inter alia, wherein: R1 and R2 are, independently, selected from the group consisting of 3-thienyl, pyridyl, benzyl, pyrimidyl, thiazolyl, isothiazolyl and C3-7cycloalkyl.
摘要翻译： 本发明涉及式（I）的新颖的毒蕈碱乙酰胆碱受体拮抗剂，药物组合物及其使用方法。 式（I）的化合物尤其是其中：R 1和R 2独立地选自3-噻吩基，吡啶基，苄基，嘧啶基，噻唑基，异噻唑基和C 3-7 >环烷基。
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公开(公告)号：US20080275079A1
公开(公告)日：2008-11-06
申请号：US11997466
申请日：2006-08-02
申请人： Jakob Busch-Petersen , Dramane Ibrahim Laine , Michael R. Palovich , Roderick S. Davis , Wei Fu , Haibo Xie
发明人： Jakob Busch-Petersen , Dramane Ibrahim Laine , Michael R. Palovich , Roderick S. Davis , Wei Fu , Haibo Xie
IPC分类号： A61K31/437 , C07D451/02 , A61P17/00
CPC分类号： C07D451/02
摘要： Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
摘要翻译： 提供毒蕈碱性乙酰胆碱受体拮抗剂及其使用方法。
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公开(公告)号：US20070179184A1
公开(公告)日：2007-08-02
申请号：US10581230
申请日：2004-12-03
申请人： Jakob Busch-Petersen , Jian Jin , Michael Palovich , Wei Fu
发明人： Jakob Busch-Petersen , Jian Jin , Michael Palovich , Wei Fu
IPC分类号： A61K31/454 , A61K31/445 , A61K31/522 , A61K31/52 , A61K31/502 , A61K31/517 , A61K31/53
CPC分类号： C07D405/12 , A61K9/0075 , C07D401/12 , C07D413/12 , C07D417/12
摘要： Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
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公开(公告)号：US20070179180A1
公开(公告)日：2007-08-02
申请号：US10581229
申请日：2004-12-03
申请人： Jakob Busch-Petersen , Jian Jin , Michael Palovich , Wei Fu
发明人： Jakob Busch-Petersen , Jian Jin , Michael Palovich , Wei Fu
IPC分类号： A61K31/4709 , A61K31/454 , A61K31/4545 , A61K31/453 , A61K31/452 , C07D409/02 , C07D405/02 , C07D403/02 , C07D401/02
CPC分类号： C07D211/56 , C07D215/36 , C07D263/46 , C07D277/44 , C07D317/46 , C07D333/34 , C07D401/12 , C07D405/06 , C07D409/02 , C07D409/14 , C07D413/12 , C07D417/14
摘要： Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
摘要翻译： 提供毒蕈碱性乙酰胆碱受体拮抗剂及其使用方法。
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公开(公告)号：US08044075B2
公开(公告)日：2011-10-25
申请号：US12517878
申请日：2007-12-05
申请人： Gregory L. Adams , James A. Brackley, III , Jakob Busch-Petersen , Jianghe Deng , Wei Fu , Huijie Li , Jack J. Taggart , Feng Wang , Yonghui Wang , Katherine Louisa Widdowson , Hongyi Yu
发明人： Gregory L. Adams , James A. Brackley, III , Jakob Busch-Petersen , Jianghe Deng , Wei Fu , Huijie Li , Jack J. Taggart , Feng Wang , Yonghui Wang , Katherine Louisa Widdowson , Hongyi Yu
CPC分类号： C07D285/135 , C07D417/04
摘要： This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
摘要翻译： 本发明涉及可用于治疗由趋化因子介导的疾病状态的白细胞介素-8（IL-8）的新化合物，组合物及其组合。
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公开(公告)号：US20100298387A1
公开(公告)日：2010-11-25
申请号：US12517878
申请日：2007-12-05
申请人： Gregory L. Adams , James A. Brackley, III , Jakob Busch-Petersen , Jianghe Deng , Wei Fu , Huijie Li , Jack J. Taggart , Feng Wang , Yonghui Wang , Katherine Louisa Widdowson , Hongyi Yi
发明人： Gregory L. Adams , James A. Brackley, III , Jakob Busch-Petersen , Jianghe Deng , Wei Fu , Huijie Li , Jack J. Taggart , Feng Wang , Yonghui Wang , Katherine Louisa Widdowson , Hongyi Yi
IPC分类号： A61K31/433 , C07D285/135 , A61P11/06
CPC分类号： C07D285/135 , C07D417/04
摘要： This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
摘要翻译： 本发明涉及可用于治疗由趋化因子介导的疾病状态的白细胞介素-8（IL-8）的新化合物，组合物及其组合。
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公开(公告)号：US20120040958A1
公开(公告)日：2012-02-16
申请号：US13279434
申请日：2011-10-24
申请人： Jeffrey Charles Boehm , Jakob Busch-Petersen , Wei Fu , Qi Jin , Jeffrey K. Kerns , Huijie Li , Guoliang Lin , Xichen Lin , Christopher E. Neipp
发明人： Jeffrey Charles Boehm , Jakob Busch-Petersen , Wei Fu , Qi Jin , Jeffrey K. Kerns , Huijie Li , Guoliang Lin , Xichen Lin , Christopher E. Neipp
IPC分类号： A61K31/404 , C07D409/14 , A61K31/4439 , A61K31/55 , A61K31/416 , C07D417/14 , A61K31/427 , C07D413/14 , A61K31/5377 , A61K31/553 , A61K31/496 , C07D495/08 , A61P29/00 , A61P11/06 , A61P11/00 , C07D409/04
CPC分类号： C07D409/04 , C07D409/14 , C07D417/14
摘要： The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein.The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译： 本发明涉及新的吲哚羧酰胺化合物。 具体地，本发明涉及式（I）的化合物：其中R 1，R 2，R 3，R 4和m如本文所定义。 本发明的化合物是IKK2的抑制剂，并且可用于治疗与不适当的IKK2（也称为IKK＆bgr）活性相关的疾病，例如类风湿性关节炎，哮喘，鼻炎和COPD（慢性阻塞性肺疾病）。 因此，本发明进一步涉及包含本发明化合物的药物组合物。 本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物来抑制IKK2活性和与其相关的病症的治疗方法。
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公开(公告)号：US20070185090A1
公开(公告)日：2007-08-09
申请号：US10598887
申请日：2004-03-17
申请人： Jakob Busch-Petersen , Anthony Cooper , Roderick Davis , Dramane Laine , Michael Palovich , Wei Fu
发明人： Jakob Busch-Petersen , Anthony Cooper , Roderick Davis , Dramane Laine , Michael Palovich , Wei Fu
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： C07D409/12 , C07D223/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
摘要翻译： 提供毒蕈碱性乙酰胆碱受体拮抗剂及其使用方法。
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公开(公告)号：US20060122173A1
公开(公告)日：2006-06-08
申请号：US10559154
申请日：2004-06-04
IPC分类号： C07D285/22 , A61K31/549
CPC分类号： C07D285/24 , C07D285/22
摘要： This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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公开(公告)号：US08071584B2
公开(公告)日：2011-12-06
申请号：US12532773
申请日：2008-03-20
申请人： Jeffrey Charles Boehm , Jakob Busch-Petersen , Wei Fu , Qi Jin , Jeffrey K. Kerns , Huijie Li , Guoliang Lin , Xichen Lin , Christopher E. Neipp
发明人： Jeffrey Charles Boehm , Jakob Busch-Petersen , Wei Fu , Qi Jin , Jeffrey K. Kerns , Huijie Li , Guoliang Lin , Xichen Lin , Christopher E. Neipp
IPC分类号： A61K31/397 , A61K31/55 , A61K31/5377 , A61K31/4436 , A61K31/404 , C07D409/14 , C07D413/14 , C07D209/04
CPC分类号： C07D409/04 , C07D409/14 , C07D417/14
摘要： The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译： 本发明涉及新的吲哚甲酰胺衍生物。 具体地，本发明涉及式（I）的化合物：其中R 1，R 2，R 3，R 4和m如本文所定义。 本发明的化合物是IKK2的抑制剂，并且可用于治疗与不适当的IKK2（也称为IKK＆bgr）活性相关的疾病，例如类风湿性关节炎，哮喘，鼻炎和COPD（慢性阻塞性肺疾病）。 因此，本发明进一步涉及包含本发明化合物的药物组合物。 本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物来抑制IKK2活性和与其相关的病症的治疗方法。
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