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1.发明申请WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS 审中-公开WNT拮抗剂及其在诊断和治疗WNT介导性疾病中的应用公开(公告)号：US20110311534A1
公开(公告)日：2011-12-22
申请号：US13113211
申请日：2011-05-23
IPC分类号： A61K39/395 , A61P35/00 , C07K19/00 , C12N5/071 , C12N5/09
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/71 , G01N2333/71 , Y02A50/473
摘要： The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
摘要翻译： 本发明提供了包含衍生自卷曲蛋白的Frz结构域组分，分泌的卷曲相关蛋白或Ror蛋白和Fc免疫球蛋白组分的嵌合Wnt拮抗剂，以及它们在细胞Wnt信号传导和Wnt介导的治疗和诊断检测中的用途 疾病，包括癌症。
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2.发明申请WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS 审中-公开WNT拮抗剂及其在诊断和治疗WNT介导性疾病中的应用公开(公告)号：US20120141481A1
公开(公告)日：2012-06-07
申请号：US13367760
申请日：2012-02-07
IPC分类号： A61K39/395 , A61M37/00 , A61P35/00 , C07K16/18 , C07K14/705
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/71 , G01N2333/71 , Y02A50/473
摘要： The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
摘要翻译： 本发明提供了包含衍生自卷曲蛋白的Frz结构域组分，分泌的卷曲相关蛋白或Ror蛋白和Fc免疫球蛋白组分的嵌合Wnt拮抗剂，以及它们在细胞Wnt信号传导和Wnt介导的治疗和诊断检测中的用途 疾病，包括癌症。
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3.发明授权Wnt antagonists and their use in the diagnosis and treatment of Wnt-mediated disorders 有权Wnt拮抗剂及其在诊断和治疗Wnt介导的疾病中的应用公开(公告)号：US07947277B2
公开(公告)日：2011-05-24
申请号：US11851596
申请日：2007-09-07
IPC分类号： A61K38/01 , A61K38/00 , C07K19/00 , A61K39/385
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/71 , G01N2333/71 , Y02A50/473
摘要： The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
摘要翻译： 本发明提供了包含衍生自卷曲蛋白的Frz结构域组分，分泌的卷曲相关蛋白或Ror蛋白和Fc免疫球蛋白组分的嵌合Wnt拮抗剂，以及它们在细胞Wnt信号传导和Wnt介导的治疗和诊断检测中的用途 疾病，包括癌症。
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4.发明申请WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS 审中-公开WNT拮抗剂及其在诊断和治疗WNT介导性疾病中的应用公开(公告)号：US20100266593A1
公开(公告)日：2010-10-21
申请号：US12826194
申请日：2010-06-29
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00 , C12N5/07
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/71 , G01N2333/71 , Y02A50/473
摘要： The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
摘要翻译： 本发明提供了包含衍生自卷曲蛋白的Frz结构域组分，分泌的卷曲相关蛋白或Ror蛋白和Fc免疫球蛋白组分的嵌合Wnt拮抗剂，以及它们在细胞Wnt信号传导和Wnt介导的治疗和诊断检测中的用途 疾病，包括癌症。
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5.发明申请WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS 有权WNT拮抗剂及其在诊断和治疗WNT介导性疾病中的应用公开(公告)号：US20080299136A1
公开(公告)日：2008-12-04
申请号：US11851596
申请日：2007-09-07
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/71 , G01N2333/71 , Y02A50/473
摘要： The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
摘要翻译： 本发明提供了包含衍生自卷曲蛋白的Frz结构域组分，分泌的卷曲相关蛋白或Ror蛋白和Fc免疫球蛋白组分的嵌合Wnt拮抗剂，以及它们在细胞Wnt信号传导和Wnt介导的治疗和诊断检测中的用途 疾病，包括癌症。
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