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公开(公告)号：US20190264224A1
公开(公告)日：2019-08-29
申请号：US16237425
申请日：2018-12-31
摘要： Virus vectors wherein each of the virus vectors expresses a sequence targeting a consensus conserved nucleic acid sequence, which when expressed in cells, functions as a modulator for nucleic acid encoding a domain.
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2.发明授权Vectors and methods for long-term immune evasion to prolong transplant viability 有权用于长期免疫逃避的载体和方法来延长移植生存力公开(公告)号：US08236771B2
公开(公告)日：2012-08-07
申请号：US11131507
申请日：2005-05-18
IPC分类号： C12N15/11
CPC分类号： C12N15/86 , A61K39/001 , A61K2039/5156 , A61K2039/525 , A61K2039/5256 , C12N2740/16043
摘要： Vector compositions and methods are provided for transfecting donor cell populations and tissues for grafts, for reducing expression of mismatched proteins, thereby reducing immunogenicity of the grafted cells and tissues in a recipient subject.
摘要翻译： 提供载体组合物和方法用于转染供体细胞群体和用于移植物的组织，用于减少错配蛋白质的表达，从而降低受体受试者中移植细胞和组织的免疫原性。
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公开(公告)号：US20180127779A1
公开(公告)日：2018-05-10
申请号：US15621880
申请日：2017-06-13
CPC分类号： C12N15/86 , A61K39/001 , A61K2039/5156 , A61K2039/525 , A61K2039/5256 , C12N2740/16043
摘要： A kit for altering allogeneic human cells for a human recipient where the kit includes a set of lentivirus vectors where each of the lentivirus vectors expresses a sequence targeting a consensus conserved nucleic acid sequence, which when expressed in cells, functions as a negative modulator for nucleic acid encoding a domain having a mismatch in an HLA protein and where the set of lentivirus vectors includes individual lentivirus vectors that correspond to individual HLA mismatches for a set of HLA mismatches that consist of HLA Class I mismatches and at least one HLA Class II mismatch and where the kit is for treatment of human cells by an appropriate subset of the set of lentivirus vectors based at least in part on a determined subset of the set of HLA mismatches between a human donor and a human recipient or between human cells and a human recipient
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公开(公告)号：US09677087B2
公开(公告)日：2017-06-13
申请号：US13567064
申请日：2012-08-05
CPC分类号： C12N15/86 , A61K39/001 , A61K2039/5156 , A61K2039/525 , A61K2039/5256 , C12N2740/16043
摘要： A method can include making one or more compositions for altering allogeneic cells of a human donor for a human recipient by identifying at least one mismatch in an HLA protein between the human donor and the human recipient; determining a consensus conserved nucleic acid sequence among nucleic acid sequences encoding a domain having the mismatch or among domains having a plurality of mismatches; and forming at least one of the one or more compositions by constructing a virus vector for expressing a sequence targeting the consensus conserved nucleic acid sequence, which when expressed in cells functions as a negative modulator for nucleic acid encoding the domain having the mismatch or the domains having the plurality of mismatches.
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5.发明申请公开(公告)号：US20120321598A1
公开(公告)日：2012-12-20
申请号：US13567064
申请日：2012-08-05
CPC分类号： C12N15/86 , A61K39/001 , A61K2039/5156 , A61K2039/525 , A61K2039/5256 , C12N2740/16043
摘要： A method can include making one or more compositions for altering allogeneic cells of a human donor for a human recipient by identifying at least one mismatch in an HLA protein between the human donor and the human recipient; determining a consensus conserved nucleic acid sequence among nucleic acid sequences encoding a domain having the mismatch or among domains having a plurality of mismatches; and forming at least one of the one or more compositions by constructing a virus vector for expressing a sequence targeting the consensus conserved nucleic acid sequence, which when expressed in cells functions as a negative modulator for nucleic acid encoding the domain having the mismatch or the domains having the plurality of mismatches.
摘要翻译： 一种方法可以包括通过鉴定人类供体和人类接受者之间的HLA蛋白质中的至少一个错配来制备一种或多种用于改变人类供体的同种异体细胞用于人类受体的组合物; 确定编码具有不匹配的结构域的核酸序列或具有多个错配的结构域之间的共有保守核酸序列; 以及通过构建用于表达靶向共有保守核酸序列的序列的病毒载体形成所述一种或多种组合物中的至少一种，其在细胞中表达时用作编码具有不匹配或结构域的核酸的核酸的负调节剂 具有多个不匹配。
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公开(公告)号：US20100261203A1
公开(公告)日：2010-10-14
申请号：US12755843
申请日：2010-04-07
IPC分类号： G01N33/566 , G01N33/564 , G01N33/53
CPC分类号： G01N33/56977 , G01N33/564 , G01N33/566 , G01N33/6893 , G01N2333/70503 , G01N2333/70539 , G01N2800/245 , G01N2800/52
摘要： Methods and kits are provided for determining of immunoglobulin isotypes and subclasses in a subject. In general the subject is a human who is a transplant candidate recipient or recipient, has allergies, or has an autoimmune disease. The method involves analyzing a sample of a body fluid of a transplant candidate or recipient, allergy patient or autoimmune disease sufferer and correlating the relative amounts of each immunoglobulin isotype and subtype, such that the distribution of isotypes and subtypes is an indication of success of the transplant in the candidate and recipient or the prognosis of the autoimmune disease.
摘要翻译： 提供了用于确定受试者中免疫球蛋白同种型和亚类的方法和试剂盒。 一般而言，受试者是移植候选人接受者或接受者，具有过敏反应或具有自身免疫性疾病的人。 该方法包括分析移植候选人或接受者，过敏患者或自身免疫疾病患者的体液样品，并且将每种免疫球蛋白同种型和亚型的相对量相关联，使得同种型和亚型的分布是 移植候选人和受体或预后的自身免疫性疾病。
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公开(公告)号：US09528988B2
公开(公告)日：2016-12-27
申请号：US12755843
申请日：2010-04-07
IPC分类号： G01N33/564 , G01N33/566 , G01N33/569
CPC分类号： G01N33/56977 , G01N33/564 , G01N33/566 , G01N33/6893 , G01N2333/70503 , G01N2333/70539 , G01N2800/245 , G01N2800/52
摘要： Methods and kits are provided for determining of immunoglobulin isotypes and subclasses in a subject. In general the subject is a human who is a transplant candidate recipient or recipient, has allergies, or has an autoimmune disease. The method involves analyzing a sample of a body fluid of a transplant candidate or recipient, allergy patient or autoimmune disease sufferer and correlating the relative amounts of each immunoglobulin isotype and subtype, such that the distribution of isotypes and subtypes is an indication of success of the transplant in the candidate and recipient or the prognosis of the autoimmune disease.
摘要翻译： 提供了用于确定受试者中免疫球蛋白同种型和亚类的方法和试剂盒。 一般而言，受试者是移植候选人接受者或接受者，具有过敏反应或具有自身免疫性疾病的人。 该方法包括分析移植候选人或接受者，过敏患者或自身免疫疾病患者的体液样品，并且将每种免疫球蛋白同种型和亚型的相对量相关联，使得同种型和亚型的分布是 移植候选人和受体或预后的自身免疫性疾病。
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