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公开(公告)号：US20190264224A1
公开(公告)日：2019-08-29
申请号：US16237425
申请日：2018-12-31
摘要： Virus vectors wherein each of the virus vectors expresses a sequence targeting a consensus conserved nucleic acid sequence, which when expressed in cells, functions as a modulator for nucleic acid encoding a domain.
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公开(公告)号：US20110217267A1
公开(公告)日：2011-09-08
申请号：US13072705
申请日：2011-03-26
IPC分类号： A61K35/76 , C12N9/78 , C12N15/85 , C12N15/86 , C12N15/867 , C12N5/10 , C12N7/01 , C07H21/00 , A61K48/00 , A61P35/00 , A61P19/02
CPC分类号： C12N7/00 , A61K2039/505 , C07K14/55 , C07K14/57 , C07K16/2818 , C07K2317/622 , C07K2319/00 , C12N9/1077 , C12N9/78 , C12N15/113 , C12N15/86 , C12N2310/141 , C12N2740/13043 , C12N2840/102 , C12N2840/203 , C12Y305/04001
摘要： This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
摘要翻译： 本公开提供了修饰的胞嘧啶脱氨酶（CDs）。 本公开进一步涉及表达或包含此类修饰的CD的细胞和载体以及在治疗疾病和病症中使用这些修饰的CD的方法。
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公开(公告)号：US20180127779A1
公开(公告)日：2018-05-10
申请号：US15621880
申请日：2017-06-13
CPC分类号： C12N15/86 , A61K39/001 , A61K2039/5156 , A61K2039/525 , A61K2039/5256 , C12N2740/16043
摘要： A kit for altering allogeneic human cells for a human recipient where the kit includes a set of lentivirus vectors where each of the lentivirus vectors expresses a sequence targeting a consensus conserved nucleic acid sequence, which when expressed in cells, functions as a negative modulator for nucleic acid encoding a domain having a mismatch in an HLA protein and where the set of lentivirus vectors includes individual lentivirus vectors that correspond to individual HLA mismatches for a set of HLA mismatches that consist of HLA Class I mismatches and at least one HLA Class II mismatch and where the kit is for treatment of human cells by an appropriate subset of the set of lentivirus vectors based at least in part on a determined subset of the set of HLA mismatches between a human donor and a human recipient or between human cells and a human recipient
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公开(公告)号：US09677087B2
公开(公告)日：2017-06-13
申请号：US13567064
申请日：2012-08-05
CPC分类号： C12N15/86 , A61K39/001 , A61K2039/5156 , A61K2039/525 , A61K2039/5256 , C12N2740/16043
摘要： A method can include making one or more compositions for altering allogeneic cells of a human donor for a human recipient by identifying at least one mismatch in an HLA protein between the human donor and the human recipient; determining a consensus conserved nucleic acid sequence among nucleic acid sequences encoding a domain having the mismatch or among domains having a plurality of mismatches; and forming at least one of the one or more compositions by constructing a virus vector for expressing a sequence targeting the consensus conserved nucleic acid sequence, which when expressed in cells functions as a negative modulator for nucleic acid encoding the domain having the mismatch or the domains having the plurality of mismatches.
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公开(公告)号：US08722867B2
公开(公告)日：2014-05-13
申请号：US13072705
申请日：2011-03-26
IPC分类号： A61K48/00 , C07H21/00 , C12N15/867 , A61K35/76 , C12N15/63
CPC分类号： C12N7/00 , A61K2039/505 , C07K14/55 , C07K14/57 , C07K16/2818 , C07K2317/622 , C07K2319/00 , C12N9/1077 , C12N9/78 , C12N15/113 , C12N15/86 , C12N2310/141 , C12N2740/13043 , C12N2840/102 , C12N2840/203 , C12Y305/04001
摘要： This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
摘要翻译： 本公开提供了修饰的胞嘧啶脱氨酶（CDs）。 本公开进一步涉及表达或包含此类修饰的CD的细胞和载体以及在治疗疾病和病症中使用这些修饰的CD的方法。
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公开(公告)号：US08829173B2
公开(公告)日：2014-09-09
申请号：US13072704
申请日：2011-03-26
IPC分类号： A61K48/00 , C07H21/00 , C12N15/867 , A61K35/76 , C12N15/63 , C12N9/78 , C12N15/86 , A61K38/22
CPC分类号： C12N7/00 , A61K31/513 , A61K38/2292 , A61K48/00 , C12N9/78 , C12N15/86 , C12N2740/13043 , C12N2760/16021 , C12N2760/16032 , C12N2760/16043
摘要： This disclosure provides recombinant replication competent retroviral vectors having increased stability. The disclosure further relates compositions and uses of such vectors in the treatment of disease and disorders.
摘要翻译： 本公开提供具有增加的稳定性的重组复制能力的逆转录病毒载体。 本公开进一步涉及这些载体在治疗疾病和病症中的组合物和用途。
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公开(公告)号：US20140234958A1
公开(公告)日：2014-08-21
申请号：US14181124
申请日：2014-02-14
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N2740/13043 , C12N2740/13045 , C12N2810/50 , C12N2810/80 , C12N2810/854 , C12N2810/859 , C12N2830/002 , C12N2830/008 , C12N2830/15 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/85
摘要： A recombinant replication competent retrovirus for gene deliver and gene therapy is provided. The recombinant retrovirus has a heterologous nucleic acid sequence, a sequence encoding a cell- or tissue-specific ligand or a sequence for transcriptional targeting, or a combination of both a cell- or tissue-specific ligand and a cell- or tissue-specific transcriptional targeting sequence.
摘要翻译： 提供了用于基因递送和基因治疗的重组复制型逆转录病毒。 重组逆转录病毒具有异源核酸序列，编码细胞或组织特异性配体的序列或用于转录靶向的序列，或细胞或组织特异性配体和细胞或组织特异性转录的组合 目标序列。
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公开(公告)号：US08652460B2
公开(公告)日：2014-02-18
申请号：US13290989
申请日：2011-11-07
CPC分类号： C12N15/86 , C12N2740/13043 , C12N2740/13045 , C12N2810/50 , C12N2810/80 , C12N2810/854 , C12N2810/859 , C12N2830/002 , C12N2830/008 , C12N2830/15 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/85
摘要： A recombinant replication competent retrovirus for gene deliver and gene therapy is provided. The recombinant retrovirus has a heterologous nucleic acid sequence, a sequence encoding a cell- or tissue-specific ligand or a sequence for transcriptional targeting, or a combination of both a cell- or tissue-specific ligand and a cell- or tissue-specific transcriptional targeting sequence.
摘要翻译： 提供了用于基因递送和基因治疗的重组复制型逆转录病毒。 重组逆转录病毒具有异源核酸序列，编码细胞或组织特异性配体的序列或用于转录靶向的序列，或细胞或组织特异性配体和细胞或组织特异性转录的组合 目标序列。
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9.发明申请公开(公告)号：US20120321598A1
公开(公告)日：2012-12-20
申请号：US13567064
申请日：2012-08-05
CPC分类号： C12N15/86 , A61K39/001 , A61K2039/5156 , A61K2039/525 , A61K2039/5256 , C12N2740/16043
摘要： A method can include making one or more compositions for altering allogeneic cells of a human donor for a human recipient by identifying at least one mismatch in an HLA protein between the human donor and the human recipient; determining a consensus conserved nucleic acid sequence among nucleic acid sequences encoding a domain having the mismatch or among domains having a plurality of mismatches; and forming at least one of the one or more compositions by constructing a virus vector for expressing a sequence targeting the consensus conserved nucleic acid sequence, which when expressed in cells functions as a negative modulator for nucleic acid encoding the domain having the mismatch or the domains having the plurality of mismatches.
摘要翻译： 一种方法可以包括通过鉴定人类供体和人类接受者之间的HLA蛋白质中的至少一个错配来制备一种或多种用于改变人类供体的同种异体细胞用于人类受体的组合物; 确定编码具有不匹配的结构域的核酸序列或具有多个错配的结构域之间的共有保守核酸序列; 以及通过构建用于表达靶向共有保守核酸序列的序列的病毒载体形成所述一种或多种组合物中的至少一种，其在细胞中表达时用作编码具有不匹配或结构域的核酸的核酸的负调节剂 具有多个不匹配。
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公开(公告)号：US20110287020A1
公开(公告)日：2011-11-24
申请号：US13072704
申请日：2011-03-26
IPC分类号： A61K39/395 , A61P35/00 , A61K35/48 , C12N7/01 , C07H21/02
CPC分类号： C12N7/00 , A61K31/513 , A61K38/2292 , A61K48/00 , C12N9/78 , C12N15/86 , C12N2740/13043 , C12N2760/16021 , C12N2760/16032 , C12N2760/16043
摘要： This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
摘要翻译： 本公开提供了修饰的胞嘧啶脱氨酶（CDs）。 本公开进一步涉及表达或包含此类修饰的CD的细胞和载体以及在治疗疾病和病症中使用此类修饰的CD的方法。
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