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公开(公告)号：US08436023B2
公开(公告)日：2013-05-07
申请号：US13156450
申请日：2011-06-09
申请人： Xuqing Zhang , Zhihua Sui , James C. Lanter
发明人： Xuqing Zhang , Zhihua Sui , James C. Lanter
IPC分类号： A61K31/4418 , A61K31/427 , A61K31/422 , A61K31/423 , A61K31/416 , A61K31/4178 , C07D231/56 , C07D401/14 , C07D417/14 , C07D263/32 , C07D261/20 , C07D233/64
CPC分类号： C07D413/14 , C07D401/14 , C07D403/12 , C07D403/14 , C07D417/14 , C07D471/04
摘要： The present invention comprises compounds of Formula (I). wherein: R1, R2, X, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
摘要翻译： 本发明包括式（I）的化合物。 其中：R1，R2，X和Z如说明书中所定义。 本发明还包括预防，治疗或改善综合征，病症或疾病的方法，其中所述综合征，病症或疾病是II型糖尿病，肥胖症和哮喘。 本发明还包括通过施用治疗有效量的至少一种式（I）化合物来抑制哺乳动物CCR2活性的方法。
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公开(公告)号：US20110312936A1
公开(公告)日：2011-12-22
申请号：US13161572
申请日：2011-06-16
IPC分类号： A61K31/4725 , A61K31/517 , A61K31/4709 , A61P35/00 , A61P35/02 , C07D413/14 , A61P25/00 , C07D403/12 , A61P9/00 , C07D471/04 , A61K31/502 , A61P19/00 , C07D405/14 , C07D403/14 , C07D401/14 , A61K31/5377 , C07D417/14 , A61P29/00 , A61P11/00 , A61P27/02 , A61P19/02 , A61P17/06 , A61P17/00 , A61P3/10 , A61P3/04 , A61P3/00 , A61P31/06 , A61P37/08 , A61P41/00 , A61P25/28 , A61K31/541
CPC分类号： C07D471/04 , A61K31/4709 , A61K31/4725 , A61K31/502 , A61K31/517 , A61K31/5377 , A61K31/541 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention comprises compounds of Formula I. wherein: R1, R2, R4, J, Q, and A are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
摘要翻译： 本发明包括式I化合物，其中：R1，R2，R4，J，Q和A如说明书中所定义。 本发明还包括预防，治疗或改善综合征，病症或疾病的方法，其中所述综合征，病症或疾病是II型糖尿病，肥胖症和哮喘。 本发明还包括通过施用治疗有效量的至少一种式I化合物来抑制哺乳动物CCR2活性的方法。
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公开(公告)号：US20110306592A1
公开(公告)日：2011-12-15
申请号：US13156450
申请日：2011-06-09
申请人： Xuqing Zhang , Zhihua Sui , James C. Lanter
发明人： Xuqing Zhang , Zhihua Sui , James C. Lanter
IPC分类号： A61K31/423 , A61K31/4439 , C07D417/14 , A61K31/427 , C07D413/12 , C07D401/14 , C07D403/12 , A61K31/416 , A61K31/422 , C07D403/14 , A61K31/4178 , C07D405/14 , C07D471/04 , A61P29/00 , A61P11/00 , A61P27/02 , A61P9/10 , A61P17/06 , A61P37/06 , A61P13/12 , A61P19/02 , A61P17/00 , A61P25/28 , A61P3/10 , A61P3/04 , A61P3/00 , A61P31/04 , A61P11/02 , A61P27/14 , A61P11/06 , A61P1/02 , A61P9/00 , A61P35/00 , A61P35/02 , C07D413/14
CPC分类号： C07D413/14 , C07D401/14 , C07D403/12 , C07D403/14 , C07D417/14 , C07D471/04
摘要： The present invention comprises compounds of Formula (I). wherein: R1, R2, X, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
摘要翻译： 本发明包括式（I）的化合物。 其中：R1，R2，X和Z如说明书中所定义。 本发明还包括预防，治疗或改善综合征，病症或疾病的方法，其中所述综合征，病症或疾病是II型糖尿病，肥胖症和哮喘。 本发明还包括通过施用治疗有效量的至少一种式（I）化合物来抑制哺乳动物CCR2活性的方法。
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4.发明授权3,4-diamino-3-cyclobutene-1,2-dione derivatives as potassium channel openers 有权3,4-二氨基-3-环丁烯-1,2-二酮衍生物作为钾通道开放剂公开(公告)号：US07595409B2
公开(公告)日：2009-09-29
申请号：US11693167
申请日：2007-03-29
申请人： James C. Lanter , Zhihua Sui
发明人： James C. Lanter , Zhihua Sui
IPC分类号： C07D307/94
CPC分类号： C07D307/94 , C07D405/12
摘要： The present invention is directed to novel 3,4-diamino-3-cyclobutene-1,2-dione derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel.
摘要翻译： 本发明涉及新的3,4-二氨基-3-环丁烯-1,2-二酮衍生物，含有它们的药物组合物及其在治疗与钾通道相关的病症中的用途。
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5.发明授权Benzimidazole derivatives useful as selective androgen receptor modulators (SARMS) 有权可用作选择性雄激素受体调节剂（SARMS）的苯并咪唑衍生物公开(公告)号：US08586616B2
公开(公告)日：2013-11-19
申请号：US12970554
申请日：2010-12-16
申请人： Raymond Ng , Zhihua Sui , Jihua Guan , James C. Lanter , Vernon C. Alford, Jr.
发明人： Raymond Ng , Zhihua Sui , Jihua Guan , James C. Lanter , Vernon C. Alford, Jr.
IPC分类号： A61K31/4184 , C07D235/12
CPC分类号： C07D403/06 , C07D235/10 , C07D235/12 , C07D235/16 , C07D401/06 , C07D403/10 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/10
摘要： The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有它们的药物组合物及其在治疗由雄激素受体调节的病症和状况中的用途。
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公开(公告)号：US08269015B2
公开(公告)日：2012-09-18
申请号：US12760832
申请日：2010-04-15
申请人： Xuqing Zhang , Heather Rae Hufnagel , Chaozhong Cai , James C. Lanter , Thomas P. Markotan , Zhihua Sui
发明人： Xuqing Zhang , Heather Rae Hufnagel , Chaozhong Cai , James C. Lanter , Thomas P. Markotan , Zhihua Sui
IPC分类号： C07D401/00 , A01N43/00
CPC分类号： C07D401/08 , C07D403/08 , C07D413/08 , C07D417/08 , C07D471/04
摘要： The present invention comprises compounds of Formula (I). wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
摘要翻译： 本发明包括式（I）的化合物。 其中：X，R1，R2，R3和R4如说明书中所定义。 本发明还包括预防，治疗或改善综合征，病症或疾病的方法，其中所述综合征，病症或疾病是II型糖尿病，肥胖症和哮喘。 本发明还包括通过施用治疗有效量的至少一种式（I）化合物来抑制哺乳动物CCR2活性的方法。
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7.发明申请NOVEL INDOLE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) 有权作为选择性受体调节剂（SARMS）的新型吲哚衍生物公开(公告)号：US20090216023A1
公开(公告)日：2009-08-27
申请号：US12188586
申请日：2008-08-08
申请人： James C. Lanter , Zhihua Sui , James J. Fiordeliso , Weiqin Jiang , Xuqing Zhang
发明人： James C. Lanter , Zhihua Sui , James J. Fiordeliso , Weiqin Jiang , Xuqing Zhang
IPC分类号： C07D487/04 , C07D401/02 , C07D209/12
CPC分类号： C07D209/12 , A61K31/407 , A61K31/4985 , A61K31/5025 , A61K31/519 , C07D209/08 , C07D209/30 , C07D401/04 , C07D405/04 , C07D409/04 , C07D487/04
摘要： The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
摘要翻译： 本发明涉及新的吲哚衍生物，含有它们的药物组合物及其用于治疗由雄激素受体调节的病症和状况。
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8.发明授权Benzimidazole derivatives useful as selective androgen receptor modulators (sarms) 有权可用作选择性雄激素受体调节剂（arms arms）的苯并咪唑衍生物公开(公告)号：US07566733B2
公开(公告)日：2009-07-28
申请号：US11235024
申请日：2005-09-26
申请人： Raymond Ng , Zhihua Sui , Jihua Guan , James C. Lanter , Vernon C. Alford, Jr.
发明人： Raymond Ng , Zhihua Sui , Jihua Guan , James C. Lanter , Vernon C. Alford, Jr.
IPC分类号： A61K31/4184 , C07D235/10 , C07D235/12
CPC分类号： C07D403/06 , C07D235/10 , C07D235/12 , C07D235/16 , C07D401/06 , C07D403/10 , C07D405/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/10
摘要： The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有它们的药物组合物及其在治疗由雄激素受体调节的病症和状况中的用途。
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9.发明授权Benzimidazole derivatives useful as selective androgen receptor modulators (SARMS) 有权可用作选择性雄激素受体调节剂（SARMS）的苯并咪唑衍生物公开(公告)号：US07348438B2
公开(公告)日：2008-03-25
申请号：US11235581
申请日：2005-09-26
申请人： Raymond Ng , Zhihua Sui , Jihua Guan , James C. Lanter , Vernon C. Alford, Jr.
发明人： Raymond Ng , Zhihua Sui , Jihua Guan , James C. Lanter , Vernon C. Alford, Jr.
IPC分类号： C07D235/16
CPC分类号： C07D405/06 , C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , C07D401/06 , C07D403/10 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/10
摘要： The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有它们的药物组合物及其在治疗由雄激素受体调节的病症和状况中的用途。
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10.发明授权公开(公告)号：US07288553B2
公开(公告)日：2007-10-30
申请号：US11096673
申请日：2005-04-01
申请人： James C. Lanter , Zhihua Sui , James J. Fiordeliso , Weiqin Jiang , Xuqing Zhang
发明人： James C. Lanter , Zhihua Sui , James J. Fiordeliso , Weiqin Jiang , Xuqing Zhang
IPC分类号： C07D209/12 , A61K31/404
CPC分类号： C07D209/12 , C07D405/04
摘要： The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
摘要翻译： 本发明涉及新的吲哚衍生物，含有它们的药物组合物及其用于治疗由雄激素受体调节的病症和状况。
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