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公开(公告)号：US08912229B2
公开(公告)日：2014-12-16
申请号：US14110423
申请日：2012-04-06
IPC分类号： A61K31/35 , A61K31/335 , C07D309/00 , C07D407/00 , A61K31/357 , C07D493/06 , C07D493/04 , A61K45/06
CPC分类号： C07D493/06 , A61K31/357 , A61K45/06 , C07D493/04
摘要： The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes and methods of treating cancer with the abeo-taxanes.
摘要翻译： 本申请公开了新的紫杉烷类似物，中间体及其生产方法。 本申请还涉及包含抗紫杉烷类的药物制剂和用抗紫杉烷类药物治疗癌症的方法。
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公开(公告)号：US20140093503A1
公开(公告)日：2014-04-03
申请号：US14110423
申请日：2012-04-06
IPC分类号： C07D493/06 , A61K45/06 , A61K31/357
CPC分类号： C07D493/06 , A61K31/357 , A61K45/06 , C07D493/04
摘要： The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes and methods of treating cancer with the abeo-taxanes.
摘要翻译： 本申请公开了新的紫杉烷类似物，中间体及其生产方法。 本申请还涉及包含抗紫杉烷类的药物制剂和用抗紫杉烷类药物治疗癌症的方法。
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公开(公告)号：US20150158880A1
公开(公告)日：2015-06-11
申请号：US14539706
申请日：2014-11-12
IPC分类号： C07D493/06 , A61K45/06 , A61K31/357
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K31/53 , A61K39/395 , A61K39/3955 , A61K45/06 , A61N5/10 , A61K2300/00
摘要： The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes and methods of treating cancer with the abeo-taxanes.
摘要翻译： 本申请公开了新的紫杉烷类似物，中间体及其生产方法。 本申请还涉及包含抗紫杉烷类的药物制剂和用抗紫杉烷类药物治疗癌症的方法。
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公开(公告)号：US20160176894A1
公开(公告)日：2016-06-23
申请号：US14950605
申请日：2015-11-24
IPC分类号： C07D493/06 , A61N5/10 , A61K39/395 , A61K45/06 , A61K31/357 , A61K31/53
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K31/53 , A61K39/395 , A61K39/3955 , A61K45/06 , A61N5/10 , A61K2300/00
摘要： The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes and methods of treating cancer with the abeo-taxanes.
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公开(公告)号：US09227983B2
公开(公告)日：2016-01-05
申请号：US14539706
申请日：2014-11-12
IPC分类号： C07D493/06 , A61K31/357 , A61K45/06 , A61K39/395 , A61K31/495
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K31/53 , A61K39/395 , A61K39/3955 , A61K45/06 , A61N5/10 , A61K2300/00
摘要： The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical formulations comprising abeo-taxanes and methods of treating cancer with the abeo-taxanes.
摘要翻译： 本申请公开了新的紫杉烷类似物，中间体及其生产方法。 本申请还涉及包含抗紫杉烷类的药物制剂和用抗紫杉烷类药物治疗癌症的方法。
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公开(公告)号：US20120309819A1
公开(公告)日：2012-12-06
申请号：US13489247
申请日：2012-06-05
IPC分类号： A61K31/357 , C07D407/12 , C07D305/14 , A61P35/02 , A61K31/337 , C07D317/24 , A61P35/00 , C07D493/08 , A61K31/366
CPC分类号： A61K47/545 , A61K31/337 , A61K31/357 , C07D305/14 , C07D317/24 , C07D407/12 , C07D487/04 , C07D491/14 , C07D493/06 , C07D493/08 , C07D519/00
摘要： The present application discloses an acid labile lipophilic molecular conjugate of cancer chemotherapeutic agents and methods for reducing or substantially eliminating the side effects of chemotherapy associated with the administration of a cancer chemotherapeutic agent to a patient in need thereof.
摘要翻译： 本申请公开了一种癌症化学治疗剂的酸不稳定亲脂性分子结合物和用于减少或基本上消除与向有需要的患者施用癌症化学治疗剂相关的化疗的副作用的方法。
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公开(公告)号：US08440714B2
公开(公告)日：2013-05-14
申请号：US13489247
申请日：2012-06-05
CPC分类号： A61K47/545 , A61K31/337 , A61K31/357 , C07D305/14 , C07D317/24 , C07D407/12 , C07D487/04 , C07D491/14 , C07D493/06 , C07D493/08 , C07D519/00
摘要： The present application discloses an acid labile lipophilic molecular conjugate of cancer chemotherapeutic agents and methods for reducing or substantially eliminating the side effects of chemotherapy associated with the administration of a cancer chemotherapeutic agent to a patient in need thereof.
摘要翻译： 本申请公开了一种癌症化学治疗剂的酸不稳定亲脂性分子结合物和用于减少或基本上消除与向有需要的患者施用癌症化学治疗剂相关的化疗的副作用的方法。
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