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    Heterocyclic antiviral compounds
    4.
    发明申请
    Heterocyclic antiviral compounds 有权
    杂环抗病毒化合物

    公开(公告)号：US20060025462A1

    公开(公告)日：2006-02-02

    申请号：US11190478

    申请日：2005-07-27

    申请人： James Dunn ,  Todd Elworthy ,  Dimitrios Stefanidis ,  Zachary Sweeney

    发明人： James Dunn ,  Todd Elworthy ,  Dimitrios Stefanidis ,  Zachary Sweeney

    IPC分类号： C07D249/12

    CPC分类号： C07D249/12

    摘要： The present invention relates to a compounds according to formula I, methods for treating diseases mediated by human immunodeficieny virus by administration of a compound according to formula I and pharmaceutical compositions for treating diseases mediated by human immunodeficieny virus containing a compound according to formula I where R1, R2, R3, R4, R5, are as defined herein.

    摘要翻译： 本发明涉及式I化合物，通过给予式I化合物治疗由人类免疫缺陷病毒介导的疾病的方法和用于治疗由含有式I化合物的人类免疫缺陷病毒介导的疾病的药物组合物，其中R R 1，R 2，R 3，R 4，R 5，R 5，R 4， 如本文所定义。

    PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2
    9.
    发明申请
    PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 审中-公开

    公开(公告)号：US20130267513A1

    公开(公告)日：2013-10-10

    申请号：US13697878

    申请日：2011-05-16

    申请人： Brayn Chan ,  Anthony Estrada ,  Zachary Sweeney ,  Edward Giles Mciver ,  Stephen Lewis

    发明人： Brayn Chan ,  Anthony Estrada ,  Zachary Sweeney ,  Edward Giles Mciver ,  Stephen Lewis

    IPC分类号： A61K31/437 ,  A61K31/5377 ,  A61K31/506 ,  C07D471/04

    CPC分类号： A61K31/437 ,  A61K31/506 ,  A61K31/5377 ,  C07D401/04 ,  C07D471/04

    摘要： A compound of formula Ia or formula Ib, or a pharmaceutically acceptable salt or ester thereof, wherein R1 is selected from: aryl; heteroaryl; —NHR3; fused aryl-C4-7-heterocycloalkyl; —CONR4R5; —NHCOR6; —C3-7-cycloalkyl; -0-C3-7-cycloalkyl; —NR3R6; and optionally substituted —C1-6 alkyl; wherein said aryl, heteroaryl, fused aryl-C4-7-heterocycloalkyl and C4-7-heterocycloalkyl are each optionally substituted; Q is CN, halogen, or is selected from C1-6-alkyl, C3-7-cycloalkyl, heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted with one or more substituents A; R2 is selected from hydrogen, aryl, C1-6-alkyl, C2-6-alkenyl, C3-7-cycloalkyl, heteroaryl, C4-7-heterocycloalkyl and halogen, wherein said C1-6-alkyl, Cz-B-alkenyl, aryl, heteroaryl and C4-7-heterocycloalkyl are each optionally substituted; R3 is selected from aryl, heteroaryl, C4-7-heterocycloalkyl, C3-7-cycloalkyl, fused aryl-C-heterocycloalkyl and C1-6-alkyl, each of which is optionally substituted; R4 and R5 are each independently hydrogen, or optionally substituted C3-7-cycloalkyl, aryl, heteroaryl, C1-6-alkyl or C3-6-heterocycloalkyl; or R4 and R5 together with the N to which they are attached form a C3-6-heterocycloalkyl ring; each R6 is independently selected from C1-6-alkyl, C3-7-cycloalkyl, C-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted; each R7 is selected from hydrogen, optionally substituted C1-6-alkyl and C3-7-cycloalkyl; each of R8 and R9 is independently hydrogen or optionally substituted C1-6-alkyl; or R8 and R9 together with the N to which they are attached form a C4-6-heterocycloalkyl; each R10 is selected from C3-7-cycloalkyl and optionally substituted C1-6-alkyl; each R11 is independently selected from C1-6-alkyl, C3-7-cycloalkyl, C1-6-alkyl-C3-7-cycloalkyl, C4-7-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted; A is selected from halogen, —NR4S02R5, —CN, —OR6, —NR4R5, —NR7R11, hydroxyl, —CF3, —CONR4R5, —NR4COR5, —NR7(CO)NR4R5, —N02, —C02H, —C02R6, —S02R6, —S02NR4R5, —NR4COR5, —NR4COOR5, 6-alkyl and —COR6. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formulae Ia and Ib.

    Non-nucleoside reverse transcriptase inhibitors
    10.
    发明申请
    Non-nucleoside reverse transcriptase inhibitors 失效
    非核苷逆转录酶抑制剂

    公开(公告)号：US20070078128A1

    公开(公告)日：2007-04-05

    申请号：US11541011

    申请日：2006-09-29

    申请人： Yoshihito Saito ,  Mark Smith ,  Zachary Sweeney

    发明人： Yoshihito Saito ,  Mark Smith ,  Zachary Sweeney

    IPC分类号： A61K31/5383 ,  A61K31/53 ,  A61K31/50 ,  C07D273/04 ,  C07D237/02

    CPC分类号： C07D237/04 ,  C07D237/02 ,  C07D253/06 ,  C07D253/07 ,  C07D273/04

    摘要： The present invention provides compounds of formula I where R1 to R4 are as defined herein which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides for methods of treating or preventing HIV infection with compounds according to formula I and compositions containing the same. The invention still further provides process for the preparation of compounds of formula I wherein R4 is A1 and X1 is NH or O.

    摘要翻译： 本发明提供式I化合物，其中R 1至R 4如本文所定义，其可用于治疗或预防人类免疫缺陷病毒（HIV）感染或治疗 AIDS或ARC。 本发明进一步提供了用式I化合物和含有该化合物的组合物治疗或预防HIV感染的方法。 本发明还提供了制备式I化合物的方法，其中R 4是A 1和X 1是NH或O.