公开(公告)号：US20120070562A1

公开(公告)日：2012-03-22

申请号：US12884578

申请日：2010-09-17

申请人： Salvador Avelar ,  James E. Mitchell

发明人： Salvador Avelar ,  James E. Mitchell

IPC分类号： B05D3/00

CPC分类号： A61L31/16 ,  A61F2/86 ,  A61F2240/001 ,  A61F2250/0068 ,  A61L31/14 ,  A61L2300/416 ,  A61L2300/802

摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。

公开(公告)号：US20110070357A1

公开(公告)日：2011-03-24

申请号：US12884503

申请日：2010-09-17

申请人： James E. Mitchell ,  Justin Peterson ,  Dishuan Chu ,  Joseph Traina ,  Salvador Avelar ,  Michele Silver

发明人： James E. Mitchell ,  Justin Peterson ,  Dishuan Chu ,  Joseph Traina ,  Salvador Avelar ,  Michele Silver

IPC分类号： B05D7/00

CPC分类号： A61L31/16 ,  A61F2240/001 ,  A61F2250/0068

摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。

公开(公告)号：US20120070563A1

公开(公告)日：2012-03-22

申请号：US12884596

申请日：2010-09-17

申请人： James E. Mitchell ,  William Heaton ,  Dishuan Chu ,  Terry Morgan ,  Justin Peterson ,  Joseph Traina

发明人： James E. Mitchell ,  William Heaton ,  Dishuan Chu ,  Terry Morgan ,  Justin Peterson ,  Joseph Traina

IPC分类号： B05D3/02 ,  B05D3/10

CPC分类号： A61L31/16 ,  A61F2240/001 ,  A61F2250/0068 ,  A61L2300/416

摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。

公开(公告)号：US08027756B2

公开(公告)日：2011-09-27

申请号：US11608064

申请日：2006-12-07

申请人： Robert B. Davis ,  Daniel J. Boorman ,  L. Kirk Gagnon ,  William L. Goodman ,  Alan R. Jacobsen ,  William A. Miller ,  James E. Mitchell ,  Victor A. Riley ,  William F. Royce ,  William D. Tafs

发明人： Robert B. Davis ,  Daniel J. Boorman ,  L. Kirk Gagnon ,  William L. Goodman ,  Alan R. Jacobsen ,  William A. Miller ,  James E. Mitchell ,  Victor A. Riley ,  William F. Royce ,  William D. Tafs

IPC分类号： G05D1/06

CPC分类号： G01C23/00 ,  G01C21/00 ,  G01C23/005 ,  G08G5/0021 ,  G08G5/025

摘要： Systems, computer program products, and methods for displaying navigation performance based flight path deviation information during the final approach segment to a runway and during landing of non-precision flight modes are provided. Improved graphical depictions of navigation performance based flight path deviation information provide pilots and flight crew members with clear, concise displays of the dynamic relationship between ANP and RNP, mode and aspect of flight and related procedures, intersecting flight paths, and current actual flight path deviation from a predefined flight path during the final approach segment to a runway and during landing. For example, an enhanced IAN display may include NPS-type deviation scales to show RNP/ANP relationships and predetermined RNP markers to alert the pilots and flight crew members that the FMC has transitioned from an NPS display for RNAV (LNAV/VNAV) flight procedures to an enhanced IAN display for a non-precision (non-xLS) approach and/or landing.

摘要翻译： 提供了系统，计算机程序产品以及在最终进场段到跑道和非精确飞行模式着陆期间显示导航性能的飞行路径偏差信息的方法。 基于导航性能的飞行路径偏差信息的改进图形描述为飞行员和飞行机组成员提供了ANP和RNP之间的动态关系，飞行模式和方面以及相关程序，相交飞行路径以及当前实际飞行路径偏差的清晰简明的显示 在最终进场段期间从预定义的飞行路径到跑道和着陆期间。 例如，增强的IAN显示器可以包括NPS型偏差标度以显示RNP / ANP关系和预定的RNP标记，以警告飞行员和飞行机组成员FMC已经从用于RNAV（LNAV / VNAV）飞行程序的NPS显示器转换 到非精确（非xLS）方法和/或着陆的增强型IAN显示。

公开(公告)号：US5061601A

公开(公告)日：1991-10-29

申请号：US554232

申请日：1990-07-17

申请人： Paul R. West ,  James E. Mitchell ,  Gary R. Miller ,  Paul R. Josephson, Jr. ,  Raymond W. Ryan, Jr.

发明人： Paul R. West ,  James E. Mitchell ,  Gary R. Miller ,  Paul R. Josephson, Jr. ,  Raymond W. Ryan, Jr.

IPC分类号： C08L67/06 ,  G03F7/038

CPC分类号： G03F7/0384 ,  C08L67/06

摘要： Radiation-sensitive compositions which are especially useful in the production of negative-working lithographic printing plates comprise a photocrosslinkable polymer containing the photosensitive group ##STR1## as an integral part of the polymer backbone and, in an amount sufficient to improve the properties of the composition, a polymer of vinyl pyrrolidone. The polymer of vinyl pyrrolidone improves the properties of the radiation-sensitive composition in regard to such factors as shelf life, image contrast, and developability and thereby provides a superior lithographic printing plate.

摘要翻译： 特别可用于制备负性平版印刷版的辐射敏感组合物包含含有作为聚合物主链的组成部分的光敏基团“IMAGE”的光可交联聚合物，其用量足以改善组合物的性质 ，乙烯基吡咯烷酮的聚合物。 关于诸如保质期，图像对比度和显影性的因素，乙烯基吡咯烷酮的聚合物改善了辐射敏感组合物的性能，从而提供了优异的平版印刷版。

公开(公告)号：US08423207B2

公开(公告)日：2013-04-16

申请号：US13218978

申请日：2011-08-26

申请人： Robert B. Davis ,  Daniel J. Boorman ,  L. Kirk Gagnon ,  William L. Goodman ,  Alan R. Jacobsen ,  William A. Miller ,  James E. Mitchell ,  Victor A. Riley ,  William F. Royce ,  William D. Tafs

发明人： Robert B. Davis ,  Daniel J. Boorman ,  L. Kirk Gagnon ,  William L. Goodman ,  Alan R. Jacobsen ,  William A. Miller ,  James E. Mitchell ,  Victor A. Riley ,  William F. Royce ,  William D. Tafs

IPC分类号： G05D1/00 ,  G05D1/06 ,  G05D3/00 ,  G06F17/00

CPC分类号： G01C23/00 ,  G01C21/00 ,  G01C23/005 ,  G08G5/0021 ,  G08G5/025

摘要： Systems, computer program products, and methods for displaying navigation performance based flight path deviation information during the final approach segment to a runway and during landing of non-precision flight modes are provided. Improved graphical depictions of navigation performance based flight path deviation information provide pilots and flight crew members with clear, concise displays of the dynamic relationship between ANP and RNP, mode and aspect of flight and related procedures, intersecting flight paths, and current actual flight path deviation from a predefined flight path during the final approach segment to a runway and during landing. For example, an enhanced IAN display may include NPS-type deviation scales to show RNP/ANP relationships and predetermined RNP markers to alert the pilots and flight crew members that the FMC has transitioned from an NPS display for RNAV (LNAV/VNAV) flight procedures to an enhanced IAN display for a non-precision (non-xLS) approach and/or landing.

摘要翻译： 提供了系统，计算机程序产品以及在最终进场段到跑道和非精确飞行模式着陆期间显示导航性能的飞行路径偏差信息的方法。 基于导航性能的飞行路径偏差信息的改进图形描述为飞行员和飞行机组成员提供了ANP和RNP之间的动态关系，飞行模式和方面以及相关程序，相交飞行路径以及当前实际飞行路径偏差的清晰简明的显示 在最终进场段期间从预定义的飞行路径到跑道和着陆期间。 例如，增强的IAN显示器可以包括NPS型偏差标度以显示RNP / ANP关系和预定的RNP标记，以警告飞行员和飞行机组成员FMC已经从用于RNAV（LNAV / VNAV）飞行程序的NPS显示器转换 到非精确（非xLS）方法和/或着陆的增强型IAN显示。

公开(公告)号：US20110313600A1

公开(公告)日：2011-12-22

申请号：US13218978

申请日：2011-08-26

申请人： Robert B. Davis ,  Daniel J. Boorman ,  Kirk L. Gagnon ,  William L. Goodman ,  Alan R. Jacobsen ,  William A. Miller ,  James E. Mitchell ,  Victor A. Riley ,  William F. Royce ,  William D. Tafs

发明人： Robert B. Davis ,  Daniel J. Boorman ,  Kirk L. Gagnon ,  William L. Goodman ,  Alan R. Jacobsen ,  William A. Miller ,  James E. Mitchell ,  Victor A. Riley ,  William F. Royce ,  William D. Tafs

IPC分类号： G01C23/00 ,  G05D1/00

CPC分类号： G01C23/00 ,  G01C21/00 ,  G01C23/005 ,  G08G5/0021 ,  G08G5/025

摘要： Systems, computer program products, and methods for displaying navigation performance based flight path deviation information during the final approach segment to a runway and during landing of non-precision flight modes are provided. Improved graphical depictions of navigation performance based flight path deviation information provide pilots and flight crew members with clear, concise displays of the dynamic relationship between ANP and RNP, mode and aspect of flight and related procedures, intersecting flight paths, and current actual flight path deviation from a predefined flight path during the final approach segment to a runway and during landing. For example, an enhanced IAN display may include NPS-type deviation scales to show RNP/ANP relationships and predetermined RNP markers to alert the pilots and flight crew members that the FMC has transitioned from an NPS display for RNAV (LNAV/VNAV) flight procedures to an enhanced IAN display for a non-precision (non-xLS) approach and/or landing.

摘要翻译： 提供了系统，计算机程序产品以及在最终进场段到跑道和非精确飞行模式着陆期间显示导航性能的飞行路径偏差信息的方法。 基于导航性能的飞行路径偏差信息的改进图形描述为飞行员和飞行机组成员提供了ANP和RNP之间的动态关系，飞行模式和方面以及相关程序，相交飞行路径以及当前实际飞行路径偏差的清晰简明的显示 在最终进场段期间从预定义的飞行路径到跑道和着陆期间。 例如，增强的IAN显示器可以包括NPS型偏差标度以显示RNP / ANP关系和预定的RNP标记，以警告飞行员和飞行机组成员FMC已经从用于RNAV（LNAV / VNAV）飞行程序的NPS显示器转换 到非精确（非xLS）方法和/或着陆的增强型IAN显示。

公开(公告)号：US20080140270A1

公开(公告)日：2008-06-12

申请号：US11608064

申请日：2006-12-07

申请人： Robert B. Davis ,  Daniel J. Boorman ,  L. Kirk Gagnon ,  William L. Goodman ,  Alan R. Jacobsen ,  William A. Miller ,  James E. Mitchell ,  Victor A. Riley ,  William F. Royce ,  William D. Tafs

发明人： Robert B. Davis ,  Daniel J. Boorman ,  L. Kirk Gagnon ,  William L. Goodman ,  Alan R. Jacobsen ,  William A. Miller ,  James E. Mitchell ,  Victor A. Riley ,  William F. Royce ,  William D. Tafs

IPC分类号： G01C21/00 ,  G05D1/00

CPC分类号： G01C23/00 ,  G01C21/00 ,  G01C23/005 ,  G08G5/0021 ,  G08G5/025

摘要： Systems, computer program products, and methods for displaying navigation performance based flight path deviation information during the final approach segment to a runway and during landing of non-precision flight modes are provided. Improved graphical depictions of navigation performance based flight path deviation information provide pilots and flight crew members with clear, concise displays of the dynamic relationship between ANP and RNP, mode and aspect of flight and related procedures, intersecting flight paths, and current actual flight path deviation from a predefined flight path during the final approach segment to a runway and during landing. For example, an enhanced IAN display may include NPS-type deviation scales to show RNP/ANP relationships and predetermined RNP markers to alert the pilots and flight crew members that the FMC has transitioned from an NPS display for RNAV (LNAV/VNAV) flight procedures to an enhanced IAN display for a non-precision (non-xLS) approach and/or landing.

摘要翻译： 提供了系统，计算机程序产品以及在最终进场段到跑道和非精确飞行模式着陆期间显示导航性能的飞行路径偏差信息的方法。 基于导航性能的飞行路径偏差信息的改进图形描述为飞行员和飞行机组成员提供了ANP和RNP之间的动态关系，飞行模式和方面以及相关程序，相交飞行路径以及当前实际飞行路径偏差的清晰简明的显示 在最终进场段期间从预定义的飞行路径到跑道和着陆期间。 例如，增强的IAN显示器可以包括NPS型偏差标度以显示RNP / ANP关系和预定的RNP标记，以警告飞行员和飞行机组成员FMC已经从用于RNAV（LNAV / VNAV）飞行程序的NPS显示器转换 到非精确（非xLS）方法和/或着陆的增强型IAN显示。

公开(公告)号：US5795784A

公开(公告)日：1998-08-18

申请号：US716079

申请日：1996-09-19

申请人： David C. Arnquist ,  Grady Barnes, III ,  Chadwick M. Dunn ,  Richard C. East, Jr. ,  Patrick P. Fritchie ,  Gregory E. Gardner ,  Cass J. Grandone ,  Robert C. Gray ,  James T. Holen ,  Jimmy D. McCoy ,  James E. Mitchell ,  Adrian John Murray ,  David W. Murray ,  Jack F. Ramsey ,  Neal T. Sleszynski

发明人： David C. Arnquist ,  Grady Barnes, III ,  Chadwick M. Dunn ,  Richard C. East, Jr. ,  Patrick P. Fritchie ,  Gregory E. Gardner ,  Cass J. Grandone ,  Robert C. Gray ,  James T. Holen ,  Jimmy D. McCoy ,  James E. Mitchell ,  Adrian John Murray ,  David W. Murray ,  Jack F. Ramsey ,  Neal T. Sleszynski

IPC分类号： G01N33/483 ,  G01N33/49 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04

CPC分类号： G01N35/04 ,  G01N35/0092 ,  G01N2035/00534 ,  G01N2035/00752 ,  G01N2035/0465 ,  G01N2035/0467 ,  G01N35/025 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/115831

摘要： Embodiments described herein provide methods of performing a process for determining an item of interest in a sample. In one embodiment, a container for holding the sample is accepted in a process lane where a process step is selectively automatically performed on the sample in the container. The process step is selectively automatically performed on the sample in the container. An effective length of the process lane is maintained constant while a physical length of the process lane is selectively varied.

摘要翻译： 本文描述的实施例提供了执行用于确定样本中的感兴趣项目的过程的方法。 在一个实施例中，用于保持样品的容器在处理通道中被接受，其中对容器中的样品选择性地自动执行处理步骤。 选择性地自动对容器中的样品进行处理步骤。 过程车道的有效长度保持恒定，同时选择性地改变过程车道的物理长度。

公开(公告)号：US5358691A

公开(公告)日：1994-10-25

申请号：US126447

申请日：1993-09-24

申请人： Frederic L. Clark ,  Gilbert Clift ,  Kendall B. Hendrick ,  William J. Kanewske, III ,  Peter A. Lagocki ,  Richard R. Martin ,  James E. Mitchell ,  Larry W. Moore ,  Charles D. Pennington ,  Edna S. Walker ,  B. Jane Smith ,  Apparao Tayi ,  James A. Vaught ,  David A. Yost

发明人： Frederic L. Clark ,  Gilbert Clift ,  Kendall B. Hendrick ,  William J. Kanewske, III ,  Peter A. Lagocki ,  Richard R. Martin ,  James E. Mitchell ,  Larry W. Moore ,  Charles D. Pennington ,  Edna S. Walker ,  B. Jane Smith ,  Apparao Tayi ,  James A. Vaught ,  David A. Yost

IPC分类号： G01N21/64 ,  B01L3/00 ,  B01L3/08 ,  B01L9/06 ,  B29C45/00 ,  G01N1/00 ,  G01N21/03 ,  G01N21/25 ,  G01N21/27 ,  G01N21/49 ,  G01N21/59 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  H01J49/04 ,  G01N35/06

CPC分类号： H01J49/04 ,  B01L3/08 ,  B01L3/5025 ,  B01L3/50853 ,  B29C45/00 ,  G01N21/03 ,  G01N21/253 ,  G01N33/5302 ,  G01N33/537 ,  G01N33/538 ,  G01N33/542 ,  G01N33/54313 ,  G01N35/0092 ,  G01N35/025 ,  B01L2200/142 ,  B01L2300/042 ,  B01L2300/043 ,  B01L3/5085 ,  B01L9/06 ,  B29K2995/0032 ,  B29L2023/22 ,  G01N2001/007 ,  G01N2035/00168 ,  G01N2035/00287 ,  G01N2035/00356 ,  G01N2035/00386 ,  G01N2035/00455 ,  G01N2035/00475 ,  G01N2035/00495 ,  G01N2035/00524 ,  G01N2035/00752 ,  G01N2035/0093 ,  G01N2035/0405 ,  G01N2035/0436 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0453 ,  G01N2035/0465 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2035/1086 ,  G01N35/0099 ,  G01N35/1065 ,  Y10S435/809 ,  Y10S436/807 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： An automated, continuous and random access analytical system, having apparatus and methodology capable of simultaneously performing multiple assays of liquid samples using different assay methodologies, and providing continuous and random access while performing a plurality of different assays on the same or different samples during the same time period, is disclosed. A method is also disclosed of operating an automated continuous and random access analytical system capable of simultaneously effecting multiple assays of a plurality of liquid samples wherein scheduling of various assays of the plurality of liquid samples is followed by creating a unit dose disposable and separately transferring a first liquid sample and reagents to a reaction vessel without initiation of an assay reaction sequence, followed by physical transfer of the unit dose disposable to a processing workstation, whereby a mixture of the unit dose disposable reagents and sample are achieved during incubation. The system is capable of performing more than one scheduled assay in any order, and assays where more than such scheduled assays are presented. The automated, continuous and random access analytical system is also capable of analyzing the incubated reaction mixtures independently and individually by at least two assay procedures.

摘要翻译： 一种自动化，连续和随机存取分析系统，其具有能够使用不同测定方法同时进行液体样品的多个测定的装置和方法，并且在相同或不同样品的同一或不同样品上进行多个不同测定 时间段被披露。 还公开了一种操作自动连续和随机存取分析系统的方法，其能够同时进行多个液体样品的多次测定，其中多个液体样品的各种测定的调度之后是产生单位剂量一次性并分别转移 将第一液体样品和试剂加入到反应容器中，而不引发测定反应顺序，随后将单位剂量一次性物理转移到加工工作站，由此在孵育期间实现单位剂量的一次性试剂和样品的混合物。 该系统能够以任何顺序执行多于一次的计划分析，以及多于此类计划测定的测定。 自动，连续和随机存取分析系统还能够通过至少两种测定程序独立地和单独地分析温育的反应混合物。