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公开(公告)号：US08436157B2
公开(公告)日：2013-05-07
申请号：US12409951
申请日：2009-03-24
IPC分类号： C07H1/00
摘要： The present invention provides a method for producing sucralose from a feed stream including a sucrose-6-acylate in a reaction vehicle. The method includes: (i) reacting the sucrose-6-acylate with a chlorinating agent in order to chlorinate the 4, 1′ and 6′ positions of the sucrose-6-acylate; (ii) quenching the product stream of (i) with an aqueous solution of a base to provide a sucralose-6-acylate and the chloride salt of said base, wherein the concentration of the aqueous solution of the base is sufficiently high such that at least a portion of the chloride salt of the base is formed as a precipitate; (iii) either: deacylating the sucralose-6-acylate by treating the product stream of (ii) with a base and thereafter removing precipitated salt to provide a product stream including sucralose; or: removing precipitated salt from the product stream of (ii) and thereafter deacylating the sucralose-6-acylate by treating with a base to provide a product stream including sucralose; and (iv) isolating sucralose from the product stream of (iii).
摘要翻译： 本发明提供了在反应载体中从包含蔗糖-6-酰化物的进料流中制备三氯半乳蔗糖的方法。 该方法包括：（i）使蔗糖-6-酰化物与氯化剂反应，以使蔗糖-6-酰化物的4,1'和6'位置氯化; （ii）用碱的水溶液淬灭（i）的产物流，得到三氯半乳蔗糖-6-酰化物和所述碱的氯化物盐，其中碱的水溶液的浓度足够高，使得在 至少一部分碱的氯化物盐形成沉淀物; （iii）：通过用碱处理（ii）的产物流，然后除去沉淀的盐以提供包含三氯蔗糖的产物流，使三氯蔗糖-6-酰化物脱酰化; 或者：从（ii）的产物流中除去沉淀的盐，然后用碱处理三氯半乳蔗糖-6-酰化物，以提供包含三氯蔗糖的产物流; 和（iv）从（iii）的产物流中分离三氯半乳蔗糖。
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公开(公告)号：US20090247737A1
公开(公告)日：2009-10-01
申请号：US12409951
申请日：2009-03-24
IPC分类号： C07H1/00
摘要： The present invention provides a method for producing sucralose from a feed stream including a sucrose-6-acylate in a reaction vehicle. The method includes: (i) reacting the sucrose-6-acylate with a chlorinating agent in order to chlorinate the 4, 1′ and 6′ positions of the sucrose-6-acylate; (ii) quenching the product stream of (i) with an aqueous solution of a base to provide a sucralose-6-acylate and the chloride salt of said base, wherein the concentration of the aqueous solution of the base is sufficiently high such that at least a portion of the chloride salt of the base is formed as a precipitate; (iii) either: deacylating the sucralose-6-acylate by treating the product stream of (ii) with a base and thereafter removing precipitated salt to provide a product stream including sucralose; or: removing precipitated salt from the product stream of (ii) and thereafter deacylating the sucralose-6-acylate by treating with a base to provide a product stream including sucralose; and (iv) isolating sucralose from the product stream of (iii).
摘要翻译： 本发明提供了在反应载体中从包含蔗糖-6-酰化物的进料流中制备三氯半乳蔗糖的方法。 该方法包括：（i）使蔗糖-6-酰化物与氯化剂反应，以使蔗糖-6-酰化物的4,1'和6'位置氯化; （ii）用碱的水溶液淬灭（i）的产物流，得到三氯半乳蔗糖-6-酰化物和所述碱的氯化物盐，其中碱的水溶液的浓度足够高，使得在 至少一部分碱的氯化物盐形成沉淀物; （iii）：通过用碱处理（ii）的产物流，然后除去沉淀的盐以提供包含三氯蔗糖的产物流，使三氯蔗糖-6-酰化物脱酰化; 或者：从（ii）的产物流中除去沉淀的盐，然后用碱处理三氯半乳蔗糖-6-酰化物，以提供包含三氯蔗糖的产物流; 和（iv）从（iii）的产物流中分离三氯半乳蔗糖。
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公开(公告)号：US20090259034A1
公开(公告)日：2009-10-15
申请号：US12403762
申请日：2009-03-13
IPC分类号： C07H3/04
CPC分类号： C07C231/24 , B01D11/0426 , B01D11/0446 , B01D11/0476 , B01D11/0492 , C07H1/06 , C07H5/02 , C07H13/04 , C07C233/03
摘要： A method of removing a carboxylic acid from a liquid that contains a tertiary amide solvent includes a step of contacting the liquid with an extraction medium comprising an amine. The amine is immiscible with both water and the tertiary amide solvent, and the contacting step forms a de-acidified phase containing the tertiary amide solvent and a phase containing the extraction medium and the carboxylic acid. Both the liquid that contains the tertiary amide solvent and the de-acidified phase may also contain a sucrose-6-acylate.
摘要翻译： 从含有叔酰胺溶剂的液体中除去羧酸的方法包括使液体与包含胺的萃取介质接触的步骤。 胺与水和叔酰胺溶剂不混溶，接触步骤形成含有叔酰胺溶剂的脱酸相和含有萃取介质和羧酸的相。 含有叔酰胺溶剂和脱酸相的液体也可以含有蔗糖-6-酰化物。
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公开(公告)号：US20090264633A1
公开(公告)日：2009-10-22
申请号：US12345998
申请日：2008-12-30
申请人： John Kerr , Robert Jansen , Duane A. Leinhos , James Edwin Wiley, JR. , Sebastien Camborieux , Anthony Baiada , Gordon Walker , Carlo Maffezzoni
发明人： John Kerr , Robert Jansen , Duane A. Leinhos , James Edwin Wiley, JR. , Sebastien Camborieux , Anthony Baiada , Gordon Walker , Carlo Maffezzoni
IPC分类号： C07H15/00
摘要： The present invention provides a method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle. The feed stream includes a sucralose-6-acylate, the reaction vehicle, water, and salts. The salts include one or more selected from the group consisting of alkali metal chlorides, alkaline earth metal chlorides and ammonium chloride. The method includes: (i) deacylation of the sucralose-6-acylate by treatment with a base to afford a product stream comprising sucralose; (ii) partial removal of water and, optionally, reaction vehicle from the product stream of (i) in order to cause precipitation of the salts from the product stream; (iii) removal of the precipitated salts from the product stream of (ii); and (iv) isolation of sucralose from the product stream of (iii).
摘要翻译： 本发明提供了由反应载体中蔗糖-6-酰化物的氯化得到的进料流中生产三氯蔗糖的方法。 进料流包括三氯蔗糖-6-酰化物，反应载体，水和盐。 所述盐包括选自碱金属氯化物，碱土金属氯化物和氯化铵中的一种或多种。 该方法包括：（i）用碱处理三氯半乳蔗糖-6-酰化物脱酰基，得到包含三氯蔗糖的产物流; （ii）从（i）的产物流中部分除去水和任选的反应载体，以便使产物流中的盐沉淀; （iii）从（ii）的产物流中除去沉淀的盐; 和（iv）从（iii）的产物流中分离三氯半乳蔗糖。
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公开(公告)号：US08476424B2
公开(公告)日：2013-07-02
申请号：US12403762
申请日：2009-03-13
CPC分类号： C07C231/24 , B01D11/0426 , B01D11/0446 , B01D11/0476 , B01D11/0492 , C07H1/06 , C07H5/02 , C07H13/04 , C07C233/03
摘要： A method of removing a carboxylic acid from a liquid that contains a tertiary amide solvent includes a step of contacting the liquid with an extraction medium comprising an amine. The amine is immiscible with both water and the tertiary amide solvent, and the contacting step forms a de-acidified phase containing the tertiary amide solvent and a phase containing the extraction medium and the carboxylic acid. Both the liquid that contains the tertiary amide solvent and the de-acidified phase may also contain a sucrose-6-acylate.
摘要翻译： 从含有叔酰胺溶剂的液体中除去羧酸的方法包括使液体与包含胺的萃取介质接触的步骤。 胺与水和叔酰胺溶剂不混溶，接触步骤形成含有叔酰胺溶剂的脱酸相和含有萃取介质和羧酸的相。 含有叔酰胺溶剂和脱酸相的液体也可以含有蔗糖-6-酰化物。
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公开(公告)号：US08436156B2
公开(公告)日：2013-05-07
申请号：US12345998
申请日：2008-12-30
申请人： John Kerr , Robert Jansen , Duane A. Leinhos , James Edwin Wiley, Jr. , Sebastien Camborieux , Anthony Baiada , Gordon Walker , Carlo Maffezzoni
发明人： John Kerr , Robert Jansen , Duane A. Leinhos , James Edwin Wiley, Jr. , Sebastien Camborieux , Anthony Baiada , Gordon Walker , Carlo Maffezzoni
IPC分类号： C07H15/00
摘要： The present invention provides a method for producing sucralose from a feed stream resulting from the chlorination of a sucrose-6-acylate in a reaction vehicle. The feed stream includes a sucralose-6-acylate, the reaction vehicle, water, and salts. The salts include one or more selected from the group consisting of alkali metal chlorides, alkaline earth metal chlorides and ammonium chloride. The method includes: (i) deacylation of the sucralose-6-acylate by treatment with a base to afford a product stream comprising sucralose; (ii) partial removal of water and, optionally, reaction vehicle from the product stream of (i) in order to cause precipitation of the salts from the product stream; (iii) removal of the precipitated salts from the product stream of (ii); and (iv) isolation of sucralose from the product stream of (iii).
摘要翻译： 本发明提供了由反应载体中蔗糖-6-酰化物的氯化得到的进料流中生产三氯蔗糖的方法。 进料流包括三氯蔗糖-6-酰化物，反应载体，水和盐。 所述盐包括选自碱金属氯化物，碱土金属氯化物和氯化铵中的一种或多种。 该方法包括：（i）用碱处理三氯半乳蔗糖-6-酰化物脱酰基，得到包含三氯蔗糖的产物流; （ii）从（i）的产物流中部分除去水和任选的反应载体，以便使产物流中的盐沉淀; （iii）从（ii）的产物流中除去沉淀的盐; 和（iv）从（iii）的产物流中分离三氯半乳蔗糖。
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7.发明申请公开(公告)号：US20090281295A1
公开(公告)日：2009-11-12
申请号：US12417153
申请日：2009-04-02
IPC分类号： C07H17/04
摘要： A process for the purification of sucralose in sucralose-containing feed streams is disclosed. The process includes multiple liquid-liquid extraction steps; optionally, a concentration step; multiple crystallization steps; optionally, a chromatography step; and various recycle steps.
摘要翻译： 公开了一种在含三氯蔗糖的进料流中纯化三氯蔗糖的方法。 该方法包括多个液 - 液萃取步骤; 任选地，浓缩步骤; 多结晶步骤; 任选地，色谱步骤; 和各种回收步骤。
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公开(公告)号：US20080227971A1
公开(公告)日：2008-09-18
申请号：US12004260
申请日：2007-12-20
IPC分类号： C07H1/06
CPC分类号： C07H5/02
摘要： A method of making sucralose includes maintaining a solution of a sucralose-6-acylate in an aqueous solvent at a temperature in a range from −20° C. to 20° C. and at a pH of at least 12.2 and less than 14.0 for a period of time sufficient to deacylate substantially all of the sucralose-6-acylate. The method may employ purified sucralose-6-acylate as the starting material, or the sucralose-6-acylate may be present in a quenched reaction mixture resulting from chlorination of a sucrose-6-acylate. The quenched reaction mixture may be exposed to deacylation conditions either before or after removal of a tertiary amide that may be present in it. Sucralose is subsequently recovered to complete the process.
摘要翻译： 制备三氯蔗糖的方法包括在-20℃至20℃的温度范围内保持三氯蔗糖-6-酰化物在水性溶剂中的溶液，并且在至少12.2和小于14.0的pH下保持 足以使基本上所有的三氯蔗糖-6-酰化物脱酰基化的时间。 该方法可以使用纯化的三氯半乳蔗糖-6-酰化物作为起始原料，或三氯蔗糖-6-酰化物可存在于由蔗糖-6-酰化物氯化得到的骤冷反应混合物中。 在除去可能存在的叔酰胺之前或之后，骤冷的反应混合物可能暴露于脱酰基化条件。 随后回收三氯蔗糖以完成该过程。
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公开(公告)号：US5977349A
公开(公告)日：1999-11-02
申请号：US022071
申请日：1998-02-11
摘要： A process for separating, in the liquid phase, a reaction mixture which comprises a first chlorinated sucrose and at least one additional component selected from the group consisting of at least one other chlorinated sucrose different from said first chlorinated sucrose, salt and solvent, by injecting said reaction mixture onto a fixed bed of solid adsorbent and treating with a desorbent such that:(a) the first chlorinated sucrose passes through the adsorbent into a first recoverable product stream rich in said first chlorinated sucrose at a rate, which is different than the rate at which,(b) at least one of said additional components passes through the adsorbent into at least a second recoverable stream rich in said additional component.
摘要翻译： 一种在液相中分离反应混合物的方法，该反应混合物包含第一氯化蔗糖和至少一种选自至少一种其它不同于所述第一氯化蔗糖，盐和溶剂的氯化蔗糖的另外的组分，通过注射 所述反应混合物在固定床上固体吸附剂上并用解吸剂处理，使得：（a）第一氯化蔗糖以不同于第一氯化蔗糖的速率通过吸附剂进入富含所述第一氯化蔗糖的第一可回收产物流中 （b）所述附加组分中的至少一种通过吸附剂至少富含所述另外组分的第二可回收流。
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