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1.发明申请Methods for Prediction and Prognosis of Cancer, and Monitoring Cancer Therapy 审中-公开癌症预测与预后方法及癌症治疗监测方法公开(公告)号：US20080311601A1
公开(公告)日：2008-12-18
申请号：US12091889
申请日：2006-11-01
IPC分类号： G01N33/574 , C12Q1/02
CPC分类号： G01N33/57492 , G01N2333/475 , G01N2333/71 , G01N2800/52
摘要： The present invention relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of VEGF as a biomarker for multi-kinase inhibitors.
摘要翻译： 本发明涉及生物标志物和生物标志物用于癌症的预测和预后以及使用生物标志物来监测癌症治疗的功效的用途。 具体地，本发明涉及VEGF作为多激酶抑制剂的生物标志物的用途。
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2.发明申请Methods for Prediction and Prognosis of Cancer, and Monitoring Cancer Therapy 审中-公开癌症预测与预后方法及癌症治疗监测方法公开(公告)号：US20080311604A1
公开(公告)日：2008-12-18
申请号：US12091899
申请日：2006-11-01
CPC分类号： G01N33/57492 , G01N2333/475 , G01N2333/71
摘要： The present invention relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of soluble VEGF-R2 as a biomarker for multi-kinase inhibitors.
摘要翻译： 本发明涉及生物标志物和生物标志物用于癌症的预测和预后以及使用生物标志物来监测癌症治疗的功效的用途。 具体地，本发明涉及可溶性VEGF-R2作为多激酶抑制剂的生物标志物的用途。
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公开(公告)号：US20060240441A1
公开(公告)日：2006-10-26
申请号：US10574398
申请日：2004-10-01
申请人： Ian Taylor , Nicole Pauloski , Douglas Bigwood
发明人： Ian Taylor , Nicole Pauloski , Douglas Bigwood
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/142
摘要： The present invention relates to gene expression profiles for lung cancer, microarrays comprising nucleic acid sequences representing gene expression profiles, and methods of using expression profiles and microarrays. The invention also provides methods and compositions for diagnostic assays for detecting cancer and therapeutic methods and compositions for treating cancer. The invention also provides methods for designing, identifying, and optimizing therapeutics for cancer.
摘要翻译： 本发明涉及肺癌的基因表达谱，包含代表基因表达谱的核酸序列的微阵列，以及使用表达谱和微阵列的方法。 本发明还提供了用于检测癌症的诊断测定法和用于治疗癌症的治疗方法和组合物的方法和组合物。 本发明还提供了用于设计，鉴定和优化癌症治疗剂的方法。
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公开(公告)号：US20130143762A1
公开(公告)日：2013-06-06
申请号：US13738207
申请日：2013-01-10
申请人： Ian Taylor , Douglas Bigwood
发明人： Ian Taylor , Douglas Bigwood
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5023 , G01N33/57484
摘要： The present invention relates to gene expression profiles, microarrays comprising nucleic acid sequences representing gene expression profiles, and methods of using expression profiles and microarrays. The invention also provides methods and compositions for diagnostic assays for detecting cancer and therapeutic methods and compositions for treating cancer. The invention also provides methods for designing, identifying, and optimizing therapeutics for cancer.
摘要翻译： 本发明涉及基因表达谱，包含代表基因表达谱的核酸序列的微阵列，以及使用表达谱和微阵列的方法。 本发明还提供用于检测癌症的诊断测定法和用于治疗癌症的治疗方法和组合物的方法和组合物。 本发明还提供了用于设计，鉴定和优化癌症治疗剂的方法。
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公开(公告)号：US20100233680A1
公开(公告)日：2010-09-16
申请号：US12092987
申请日：2006-11-10
申请人： Ian Taylor , Douglas Bigwood
发明人： Ian Taylor , Douglas Bigwood
CPC分类号： C12Q1/6837 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5023 , G01N33/57484
摘要： The present invention relates to gene expression profiles, microarrays comprising nucleic acid sequences representing gene expression profiles, and methods of using expression profiles and microarrays. The invention also provides methods and compositions for diagnostic assays for detecting cancer and therapeutic methods and compositions for treating cancer. The invention also provides methods for designing, identifying, and optimizing therapeutics for cancer.
摘要翻译： 本发明涉及基因表达谱，包含代表基因表达谱的核酸序列的微阵列，以及使用表达谱和微阵列的方法。 本发明还提供了用于检测癌症的诊断测定法和用于治疗癌症的治疗方法和组合物的方法和组合物。 本发明还提供了用于设计，鉴定和优化癌症治疗剂的方法。
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公开(公告)号：US20100209914A1
公开(公告)日：2010-08-19
申请号：US12513764
申请日：2008-05-26
申请人： Douglas Bigwood , Eric Eastman , Eric Kaldjian
发明人： Douglas Bigwood , Eric Eastman , Eric Kaldjian
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention provides a method for evaluating multiple sclerosis (MS), or excluding MS as a diagnosis for a patient The method comprises determining a gene expression profile for a sample from such a patient. The gene expression profile, which contains gene expression values for a plurality of genes that are differentially expressed in white blood cells of MS patients, is compared to an MS-profile and/or a non-MS profile, and classified. The invention also provides a method for monitoring treatment of an MS patient Pre-treatment and post-treatment gene expression profiles contain gene expression values for a plurality of genes that are differentially expressed upon treatment of MS patients. The expression profiles may then be compared, to identify differences between pre-treatment and post-treatment gene expression. These differences are indicative of the patient's response to treatment The invention further provides kits and systems for performing the methods of the invention.
摘要翻译： 本发明提供了一种评价多发性硬化（MS）或不包括MS作为患者诊断的方法。该方法包括确定来自该患者的样品的基因表达谱。 将包含MS患者的白细胞中差异表达的多个基因的基因表达值的基因表达谱与MS谱和/或非MS谱进行比较并分类。 本发明还提供了用于监测MS患者治疗的方法。预处理和后处理基因表达谱包含在治疗MS患者时差异表达的多个基因的基因表达值。 然后可以比较表达谱，以鉴定预处理和后处理基因表达之间的差异。 这些差异表示患者对治疗的反应本发明还提供用于实施本发明方法的试剂盒和系统。
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