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    CDNAS coding for members of the carcinoembryonic antigen family
    4.
    发明授权
    CDNAS coding for members of the carcinoembryonic antigen family 失效
    癌细胞抗原家族成员的CDNAS编码

    公开(公告)号：US5231009A

    公开(公告)日：1993-07-27

    申请号：US760031

    申请日：1991-09-13

    申请人： Thomas R. Barnett ,  James J. Elting ,  Michael E. Kamarck ,  Axel W. Kretschmer

    发明人： Thomas R. Barnett ,  James J. Elting ,  Michael E. Kamarck ,  Axel W. Kretschmer

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C07K16/30 ,  C12N1/21 ,  C12Q1/68

    CPC分类号： C07K14/705 ,  C07K16/3007 ,  C12Q1/6886 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/40 ,  C12Q2600/158

    摘要： A nucleic acid comprising a base sequence which codes for a CEA family member peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or injected with such cloning vehicles, polypeptides expressed by such cells, synthetic peptides derived from the coding sequence of CEA family member nucleic acids, antibody preparations specific for such polypeptides, immunoassays for detecting CEA family members using such antibody preparations and nucleic acid hybridization methods for detecting CEA family member nucleic acid sequences using a nucleic acid probe comprising the above described nucleic acid.

    摘要翻译： 一种核酸，其包含编码CEA家族成员肽序列的碱基序列或具有与其可杂交的碱基序列的核酸，具有包含该核酸的插入片段的可复制重组克隆载体，用该克隆载体转染，感染或注射的细胞，多肽 由这样的细胞表达，衍生自CEA家族成员核酸的编码序列的合成肽，对这些多肽具有特异性的抗体制剂，使用这种抗体制剂检测CEA家族成员的免疫测定法和用于检测CEA家族成员核酸序列的核酸杂交方法，其使用 包含上述核酸的核酸探针。

    Bioassay of parathyroid hormone
    5.
    发明授权
    Bioassay of parathyroid hormone 失效
    甲状旁腺激素的生物测定

    公开(公告)号：US4508828A

    公开(公告)日：1985-04-02

    申请号：US477253

    申请日：1983-03-21

    申请人： Arnold W. Lindall ,  James J. Elting

    发明人： Arnold W. Lindall ,  James J. Elting

    IPC分类号： G01N33/78 ,  G01N33/56 ,  G01N33/58 ,  G01N33/60

    CPC分类号： G01N33/78 ,  Y10S436/804 ,  Y10S436/808 ,  Y10S436/817 ,  Y10S436/824 ,  Y10S436/825

    摘要： A method is disclosed for extraction, concentration, and bioassay measurement of the concentration of bioactive parathyroid peptides in biological or other fluids. Parathyroid peptides are extracted from the fluid by a support-antibody matrix specific to the N-terminal region. The bioassay is directed to the extracted parathyroid peptides. The volume of the medium containing the extracted parathyroid peptides and tissue, cells or tissue extracts with adenylate cyclase-coupled parathyroid hormone receptors may be chosen to be significantly less than the volume of biological or other fluid being assayed.

    摘要翻译： 公开了用于提取，浓缩和生物测定生物或其它流体中生物活性甲状旁腺肽浓度的方法。 通过特异于N-末端区域的载体 - 抗体基质从流体中提取甲状旁腺肽。 生物测定指向提取的甲状旁腺肽。 含有提取的甲状旁腺肽和组织，含腺苷酸环化酶偶联甲状旁腺激素受体的细胞或组织提取物的培养基的体积可以选择为显着小于被测定的生物或其他流体的体积。

    cDNAs coding for members of the carcinoembryonic antigen family
    6.
    发明授权
    cDNAs coding for members of the carcinoembryonic antigen family 失效
    编码癌胚抗原家族成员的cDNA

    公开(公告)号：US06342583B1

    公开(公告)日：2002-01-29

    申请号：US08027974

    申请日：1993-03-08

    申请人： Thomas R. Barnett ,  James J. Elting ,  Michael E. Kamarck ,  Axel W. Kretschmer

    发明人： Thomas R. Barnett ,  James J. Elting ,  Michael E. Kamarck ,  Axel W. Kretschmer

    IPC分类号： C07K1400

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K16/3007 ,  C07K2319/00 ,  C07K2319/40 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： A nucleic acid comprising a base sequence which codes for a CEA family member peptide sequence or nucleic acids having a base sequence hybridizable therewith, replicable recombinant cloning vehicles having an insert comprising such nucleic acid, cells transfected, infected or injected with such cloning vehicles, polypeptides expressed by such cells, synthetic peptides derived from the coding sequence of CEA family member nucleic acids, antibody preparations specific for such polypeptides, immunoassays for detecting CEA family members using such antibody preparations and nucleic acid hybridization methods for detecting CEA family member nucleic acid sequences using a nucleic acid probe comprising the above described nucleic acid.

    摘要翻译： 一种核酸，其包含编码CEA家族成员肽序列的碱基序列或具有与其可杂交的碱基序列的核酸，具有包含该核酸的插入片段的可复制重组克隆载体，用该克隆载体转染，感染或注射的细胞，多肽 由这样的细胞表达，衍生自CEA家族成员核酸的编码序列的合成肽，对这些多肽具有特异性的抗体制剂，使用这种抗体制剂检测CEA家族成员的免疫测定法和用于检测CEA家族成员核酸序列的核酸杂交方法，其使用 包含上述核酸的核酸探针。