公开(公告)号：US20060141048A1

公开(公告)日：2006-06-29

申请号：US11304421

申请日：2005-12-15

申请人： James Kipp ,  Ton Hai ,  Bennett Melnick

发明人： James Kipp ,  Ton Hai ,  Bennett Melnick

IPC分类号： A61K9/14

CPC分类号： C08G65/334 ,  A61K8/90 ,  A61K9/146 ,  A61K47/34 ,  A61Q19/00 ,  C08G65/326 ,  C08L71/02

摘要： The present invention is directed to novel compounds, methods of manufacture and methods of use. The present invention is also directed to solid drug/active agent particles having one or more of the compounds of the present invention associated with the surface thereof. The compounds of the present invention are comprised of a non-polar polyether covalently linked to an anionic sulfonate group. The compounds have an amphipathic quality and preferably, are surface active. Such compounds are preferably useful as surface-active agents to coat and stabilize dispersions of particles in a continuous liquid medium. These surface-active agents may be applied in the stabilization of suspensions, emulsions, or liposome formulations intended for pharmaceutical, medical, cosmetic, or agricultural use. The particles that can be prepared by a variety of methods and will preferably comprise a pharmaceutical agent. Pharmaceutical compositions of the present invention can be used to treat a myriad of conditions and can be administered by many routes, including intravenous, intramuscular, subcutaneous, intrathecal, subdural, intracameral, intracerebral, intralesional, topical, oral, buccal, rectal, transcutaneous, pulmonary, and nasal.

摘要翻译： 本发明涉及新化合物，制备方法和使用方法。 本发明还涉及具有一种或多种与其表面相关的本发明化合物的固体药物/活性剂颗粒。 本发明的化合物由与阴离子磺酸盐基团共价连接的非极性聚醚组成。 该化合物具有两性质量，优选表面活性。 这些化合物优选用作表面活性剂以涂覆和稳定颗粒在连续液体介质中的分散体。 这些表面活性剂可以用于稳定用于制药，医疗，化妆品或农业用途的悬浮液，乳剂或脂质体制剂。 可以通过多种方法制备并且优选包含药剂的颗粒。 本发明的药物组合物可用于治疗无数的病症，并且可以通过许多途径施用，包括静脉内，肌肉内，皮下，鞘内，硬膜下，阴道内，脑内，肠内，局部，口腔，口腔，直肠，经皮， 肺和鼻。

公开(公告)号：US20100048483A1

公开(公告)日：2010-02-25

申请号：US12545406

申请日：2009-08-21

申请人： Guohan Yang ,  Ton T. Hai ,  Bennett Melnick ,  Paul Sanders ,  Cong Jiang ,  Catherine Quinn ,  Jie Li ,  Arounaguiry Ambroise ,  Larry R. Brown

发明人： Guohan Yang ,  Ton T. Hai ,  Bennett Melnick ,  Paul Sanders ,  Cong Jiang ,  Catherine Quinn ,  Jie Li ,  Arounaguiry Ambroise ,  Larry R. Brown

IPC分类号： A61K38/16 ,  C07D207/46 ,  C08F8/00 ,  C08B37/00 ,  C07H5/04 ,  C08B37/08 ,  C08B37/10 ,  C08B37/02 ,  C07K2/00 ,  C07K14/00 ,  C07K14/745 ,  C07K14/505 ,  C07K14/755 ,  C12N9/48 ,  A61K38/02 ,  C07C69/63 ,  C07C69/66 ,  A61P43/00

CPC分类号： A61K47/48215 ,  A61K31/405 ,  A61K47/60

摘要： The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.

摘要翻译： 本发明涉及聚合物衍生物，其可以与含氨基的药物缀合以改善其体内特性。 随后可以释放聚合物衍生物以产生其天然形式的药物。 描述了制备和使用这些聚合物衍生物和药物偶联物的方法。