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    Immunization Regimen with E4-Deleted Adenovirus Prime and E1-Deleted Adenovirus Boost
    2.
    发明申请
    Immunization Regimen with E4-Deleted Adenovirus Prime and E1-Deleted Adenovirus Boost 有权
    E4缺失腺病毒Prime和E1缺失腺病毒的免疫方案

    公开(公告)号：US20070231347A1

    公开(公告)日：2007-10-04

    申请号：US11587549

    申请日：2005-04-27

    申请人： James Wilson ,  Yan Zhi

    发明人： James Wilson ,  Yan Zhi

    IPC分类号： A61K39/235

    CPC分类号： A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/57 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10362 ,  C12N2750/14043 ,  C12N2760/14122 ,  C12N2760/14134 ,  Y02A50/484

    摘要： An immunization regimen is provided which involves priming with an E1, E4-deleted adenovirus and boosting with an E1-deleted adenovirus. The second administered adenovirus has a capsid of a serotype which is not cross-reactive with the previously administered adenovirus. Each of the adenoviruses carries a heterologous expression cassette comprising a nucleic acid sequence encoding a product for inducing an immune response under the control of regulatory control sequences which direct expression of the product. The expression cassettes can have the same or different regulatory control sequences. Further, a product containing the adenoviruses necessary to perform the immunization regimen is provided.

    摘要翻译： 提供免疫方案，其包括用E1，E4缺失的腺病毒引发并用E1缺失的腺病毒加强。 第二次施用的腺病毒具有不与先前施用的腺病毒交叉反应的血清型的衣壳。 每个腺病毒携带异源表达盒，其包含编码产物的核酸序列的核酸序列，用于在引导产物表达的调节控制序列的控制下诱导免疫应答。 表达盒可以具有相同或不同的调节控制序列。 此外，提供了含有进行免疫方案所必需的腺病毒的产品。