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公开(公告)号：US5210217A
公开(公告)日：1993-05-11
申请号：US335563
申请日：1989-04-10
IPC分类号： C07D409/04 , C07D409/14 , C07D521/00 , C08G61/12 , C12Q1/00 , C12Q1/54 , G01N33/532 , H01B1/12
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D409/04 , C07D409/14 , C08G61/123 , C12Q1/002 , C12Q1/54 , G01N33/532 , H01B1/127
摘要： Electrically conducting homo- and/or copolymers and/or tripolymers can be produced from novel monomers, such as a 3-substituted 2,5-di(2-thienyl)pyrrole. The polymers exhibit unexpectedly high stability and conductivities, and can be functionalized, such as with an enzyme, like glucose oxidase, or an ion-specific binding site, like a crown ether, or an antigen, without adversely affecting the conductivity of the polymer. The functionalized, conducting polymer can be used in a diagnostic device to determine the presence and concentration of a specific analyte in a liquid medium. For example, the presence and concentration of glucose is determined by measuring the conductivity change in the polymer caused by the vibrational excitation induced in the enzyme, glucose oxidase, from its reaction with the glucose and/or by measuring a secondary effect of the enzyme/substrate reaction, such as the change in the conductivity of the conducting polymer caused by the generation of hydrogen peroxide during the glucose-glucose oxidase reaction.
摘要翻译： 导电的均聚物和/或共聚物和/或三聚物可以由新型单体如3-取代的2,5-二（2-噻吩基）吡咯制备。 聚合物表现出意想不到的高稳定性和电导率，并且可以如酶，如葡萄糖氧化酶，或离子特异性结合位点，如冠醚或抗原而被官能化，而不会不利地影响聚合物的导电性。 官能化的导电聚合物可用于诊断装置中以确定液体介质中特定分析物的存在和浓度。 例如，葡萄糖的存在和浓度通过测量由酶，葡萄糖氧化酶，其与葡萄糖的反应引起的振动激发引起的聚合物中的电导率变化和/或通过测量酶/ 底物反应，例如在葡萄糖 - 葡萄糖氧化酶反应期间由过氧化氢的产生引起的导电聚合物的导电性的变化。
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2.发明授权
公开(公告)号：US4886625A
公开(公告)日：1989-12-12
申请号：US114011
申请日：1987-10-29
IPC分类号： C12Q1/26 , C07D333/40 , C07D409/04 , C07D409/14 , C07D419/14 , C07D421/04 , C07D421/14 , C07D521/00 , C08G61/10 , C08G61/12 , C12Q1/00 , C12Q1/54 , G01N33/532 , G01N33/543 , H01B1/12
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D409/04 , C07D409/14 , C08G61/123 , C12Q1/002 , C12Q1/54 , G01N33/532 , H01B1/127
摘要： Electrically conducting homo- and/or copolymers and/or tripolymers can be produced from novel monomers, such as a 3-substituted 2,5-di(2-thienyl)pyrrole. The polymers exhibit unexpectedly high stability and conductivities, and can be functionalized, such as with an enzyme, like glucose oxidase, or an ion-specific binding site, like a crown ether, or an antigen, without adversely affecting the conductivity of the polymer. The functionalized, conducting polymer can be used in a diagnostic device to determine the presence and concentration of a specific analyte in a liquid medium. For example, the presence and concentration of glucose is determined by measuring the conductivity change in the polymer caused by the vibrational excitation induced in the enzyme, glucose oxidase, from its reaction with the glucose and/or by measuring a secondary effect of the enzyme/substrate reaction, such as the change in the conductivity of the conducting polymer caused by the generation of hydrogen peroxide during the glucose-glucose oxidase reaction.
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3.发明授权公开(公告)号：US06673630B2
公开(公告)日：2004-01-06
申请号：US09510690
申请日：2000-02-23
IPC分类号： G01N3353
CPC分类号： G01N33/521 , Y10S435/97 , Y10S435/973 , Y10S436/81 , Y10S436/823
摘要： One embodiment of the present invention improves the visual use of urine test strips and reagent pads by providing a single color from a reference color spectrum directly on the colorimetric strip and adjacent to the reagent area to allow easy comparison. After application of a fluid to be tested to a reagent area on the colorimetric strip, a technician is able to easily compare the color in the reagent area to the reference color area(s) to determine the presence or absence of, for example, glucose, in the fluid. Placing at least one reference color immediately next to the reagent area markedly improves technician's accuracy in comparing and analyzing the reagent area against the reference color(s). The present invention allows a technician to easily and quickly compare a reagent area color to more than one reference area to determine the actual numerical value of, for example, the pH in the tested fluid.
摘要翻译： 本发明的一个实施方案通过直接在比色条上和附近的试剂区域提供来自参考色谱的单一颜色来改善尿液测试条和试剂垫的视觉用途，以便于进行比较。 在将待测试的流体施加到比色条上的试剂区域之后，技术人员能够容易地将试剂区域中的颜色与参考色彩区域进行比较，以确定是否存在例如葡萄糖 ，在流体。 在试剂区域旁边放置至少一种参考颜色，显着提高了技术人员在比较和分析试剂面积与参考颜色时的准确性。 本发明允许技术人员容易且快速地将试剂区域颜色与多于一个参考区域进行比较，以确定例如测试流体中的pH的实际数值。
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公开(公告)号：US07125481B2
公开(公告)日：2006-10-24
申请号：US10864011
申请日：2004-06-09
IPC分类号： G01N27/327 , G01N27/333
CPC分类号： C12Q1/001 , G01N27/3274
摘要： An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.
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公开(公告)号：US5250439A
公开(公告)日：1993-10-05
申请号：US990340
申请日：1992-12-14
申请人： Matthew K. Musho , J. Oakey Noell , Pius H-S. Tse
发明人： Matthew K. Musho , J. Oakey Noell , Pius H-S. Tse
CPC分类号： C12Q1/002 , C12Q1/005 , Y10T436/144444
摘要： A conductive sensor and its use in a diagnostic assay are disclosed. The miniaturized conductive sensor, utilizing a conducting polymer, is used in a diagnostic device to determine the presence or concentration of a predetermined analyte in a liquid test sample, wherein the predetermined analyte, like glucose, is assayed by an oxidase interaction. The interaction between the oxidase and a small amount of the predetermined analyte in the test sample generates, either directly or indirectly, a dopant compound in a reaction zone of the conductive sensor. The dopant compound then migrates to the detection zone of the conductive sensor of the diagnostic device to oxidize the conducting polymer and convert the conducting polymer from an insulating form to a conducting form. The resulting increase in conductivity of the conducting polymer is measured, then the conductivity increase is correlated to the concentration of the predetermined analyte in the test sample.
摘要翻译： 公开了一种导电传感器及其在诊断测定中的应用。 使用导电聚合物的小型化导电传感器用于诊断装置中以确定液体测试样品中预定分析物的存在或浓度，其中通过氧化酶相互作用测定预定分析物（如葡萄糖）。 测试样品中氧化酶与少量预定分析物之间的相互作用直接或间接地产生导电传感器反应区中的掺杂剂化合物。 然后，掺杂剂化合物迁移到诊断装置的导电传感器的检测区域，以氧化导电聚合物并将导电聚合物从绝缘形式转换为导电形式。 测量导电聚合物导电率的增加，然后电导率增加与测试样品中预定分析物的浓度相关。
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公开(公告)号：US5119819A
公开(公告)日：1992-06-09
申请号：US517699
申请日：1990-05-02
IPC分类号： A61B5/00 , A61B8/08 , G01N29/024 , G01N29/32
CPC分类号： A61B8/08 , A61B5/14532 , G01N29/024 , G01N29/326 , G01N2291/02466 , G01N2291/02809 , G01N2291/02881
摘要： A new and improved method and apparatus are provided for non-invasive monitoring of changes in blood glucose concentration in a tissue specimen and particularly in an individual. The method uses acoustic velocity measurements for monitoring the effect of glucose concentration upon the density and adiabatic compressibility of the serum.In a preferred embodiment, the acoustic velocity measurements are made through the earlobe of a subject by means of an acoustic probe or monitor which includes a transducer for transmitting and receiving ultrasonic energy pulses to and from the blood flowing in the subject's earlobe and a reflector for facilitating reflection of the acoustic pulses from the blood. The probe is designed in such a way that when properly affixed to an ear, the transducer is positioned flush against the anterior portion of an earlobe while the reflector is positioned flush against the interior portion of the earlobe. A microthermocouple is provided on the probe for monitoring the internal temperature of the blood being sampled.An electrical system, essentially comprising a frequency generator, a time intervalometer and an oscilloscope, is linked to the glucose monitoring probe. The electrical system analyzes selected ones of the pulses reflected from the blood sample in order to determine therefrom the acoustic velocity of the blood which, in turn, provides a representation of the blood glucose concentration levels at the time of the acoustic velocity measurements.
摘要翻译： 提供了一种新的和改进的方法和装置，用于非组织监测组织标本中，特别是个体中血糖浓度变化。 该方法使用声速测量来监测葡萄糖浓度对血清的密度和绝热压缩性的影响。 在优选实施例中，通过声探针或监视器通过主体的耳垂进行声速测量，所述声探头或监视器包括用于向从被检者的耳垂流动的血液发送和接收超声波能量脉冲的换能器和用于 促进来自血液的声脉冲的反射。 探针被设计成使得当适当地固定在耳朵上时，换能器被定位成与耳垂的前部相对齐，同时反射器被定位成与耳垂的内部部分齐平。 在探头上提供微热电偶，用于监测正在采样的血液的内部温度。 基本上包括频率发生器，时间间隔计和示波器的电气系统连接到葡萄糖监测探头。 电气系统分析从血液样本反射的所选脉冲中的所选脉冲，以便由此确定血液的声速，其进而提供在声速测量时血糖浓度水平的表示。
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公开(公告)号：USRE44521E1
公开(公告)日：2013-10-08
申请号：US12257031
申请日：2008-10-23
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , G01N27/3274
摘要： An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.
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公开(公告)号：US06841052B2
公开(公告)日：2005-01-11
申请号：US09861437
申请日：2001-05-21
IPC分类号： C12Q1/00 , G01N33/487 , G01N27/327 , G01N27/333
CPC分类号： C12Q1/001 , G01N27/3274
摘要： An improved electrochemical sensor having a base bearing a working and counter electrode which provides a flow path for a fluid test sample. The working and counter electrodes are configured so that a major portion of the counter electrode is located downstream on the flow path from the working electrode with the exception of a small sub-element of the counter electrode which is in electrical communication with the primary portion of the counter electrode and located upstream of the working electrode. This configuration enables the sensor when the capillary space is incompletely filled with test fluid.
摘要翻译： 一种改进的电化学传感器，其具有承载工作和对电极的基座，其提供用于流体测试样品的流动路径。 工作电极和对电极被构造成使得相对电极的主要部分位于与工作电极相距的流动路径的下游，除了对电极的小子元件之外，该小子元件与主电极 对置电极并位于工作电极的上游。 当毛细管空间未完全填充测试流体时，该配置使得传感器成为可能。
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公开(公告)号：US06531040B2
公开(公告)日：2003-03-11
申请号：US09731943
申请日：2000-12-08
IPC分类号： G01N2726
CPC分类号： C12Q1/001 , G01N27/3274
摘要： Disclosed is an electrochemical sensor for detecting the concentration of an analyte such as glucose in a fluid test sample. The sensor involves a base as flow path for the fluid test sample having a working and counter electrode on its surface. The base is mated with a cover to form a capillary space to capture the fluid and the counter electrode has a sub-element located upstream in the flow path. When there is detected electrical communication only between the sub-element and the working electrode the meter, with which the sensor is in electrical communication senses that the capillary space has not completely filled with test fluid.
摘要翻译： 公开了一种用于检测流体测试样品中诸如葡萄糖的分析物浓度的电化学传感器。 该传感器涉及一个流动测试样品的流动路径，其底部具有在其表面上的工作和反电极。 基座与盖子配合以形成毛细管空间以捕获流体，并且对电极具有位于流动路径上游的子元件。 当仅在子元件和工作电极之间检测到电气通信时，与传感器电连通的仪表可以检测到毛细管空间未完全充满测试流体。
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公开(公告)号：US5202261A
公开(公告)日：1993-04-13
申请号：US793180
申请日：1991-11-18
申请人： Matthew K. Musho , J. Oakey Noell , Pius H. Tse
发明人： Matthew K. Musho , J. Oakey Noell , Pius H. Tse
IPC分类号： C12Q1/00
CPC分类号： C12Q1/005 , C12Q1/002 , Y10S435/817
摘要： A conductive sensor and its use in a diagnostic assay are disclosed. The miniaturized conductive sensor, utilizing a conducting polymer, is used in a diagnostic device to determine the presence or concentration of a predetermined analyte in a liquid test sample, wherein the predetermined analyte, like glucose, is assayed by an oxidase interaction. The interaction between the oxidase and a small amount of the predetermined analyte in the test sample generates, either directly or indirectly, a dopant compound in a reaction zone of the conductive sensor. The dopant compound then migrates to the detection zone of the conductive sensor of the diagnostic device to oxidize the conducting polymer and convert the conducting polymer from an insulating form to a conducting form. The resulting increase in conductivity of the conducting polymer is measured, then the conductivity increase is correlated to the concentration of the predetermined analyte in the test sample.
摘要翻译： 公开了一种导电传感器及其在诊断测定中的应用。 使用导电聚合物的小型化导电传感器用于诊断装置中以确定液体测试样品中预定分析物的存在或浓度，其中通过氧化酶相互作用测定预定分析物，如葡萄糖。 测试样品中氧化酶与少量预定分析物之间的相互作用直接或间接地产生导电传感器反应区中的掺杂剂化合物。 然后，掺杂剂化合物迁移到诊断装置的导电传感器的检测区域，以氧化导电聚合物并将导电聚合物从绝缘形式转换为导电形式。 测量导电聚合物导电率的增加，然后电导率增加与测试样品中预定分析物的浓度相关。
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