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公开(公告)号：US5202261A
公开(公告)日：1993-04-13
申请号：US793180
申请日：1991-11-18
申请人： Matthew K. Musho , J. Oakey Noell , Pius H. Tse
发明人： Matthew K. Musho , J. Oakey Noell , Pius H. Tse
IPC分类号： C12Q1/00
CPC分类号： C12Q1/005 , C12Q1/002 , Y10S435/817
摘要： A conductive sensor and its use in a diagnostic assay are disclosed. The miniaturized conductive sensor, utilizing a conducting polymer, is used in a diagnostic device to determine the presence or concentration of a predetermined analyte in a liquid test sample, wherein the predetermined analyte, like glucose, is assayed by an oxidase interaction. The interaction between the oxidase and a small amount of the predetermined analyte in the test sample generates, either directly or indirectly, a dopant compound in a reaction zone of the conductive sensor. The dopant compound then migrates to the detection zone of the conductive sensor of the diagnostic device to oxidize the conducting polymer and convert the conducting polymer from an insulating form to a conducting form. The resulting increase in conductivity of the conducting polymer is measured, then the conductivity increase is correlated to the concentration of the predetermined analyte in the test sample.
摘要翻译： 公开了一种导电传感器及其在诊断测定中的应用。 使用导电聚合物的小型化导电传感器用于诊断装置中以确定液体测试样品中预定分析物的存在或浓度，其中通过氧化酶相互作用测定预定分析物，如葡萄糖。 测试样品中氧化酶与少量预定分析物之间的相互作用直接或间接地产生导电传感器反应区中的掺杂剂化合物。 然后，掺杂剂化合物迁移到诊断装置的导电传感器的检测区域，以氧化导电聚合物并将导电聚合物从绝缘形式转换为导电形式。 测量导电聚合物导电率的增加，然后电导率增加与测试样品中预定分析物的浓度相关。
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公开(公告)号：US5250439A
公开(公告)日：1993-10-05
申请号：US990340
申请日：1992-12-14
申请人： Matthew K. Musho , J. Oakey Noell , Pius H-S. Tse
发明人： Matthew K. Musho , J. Oakey Noell , Pius H-S. Tse
CPC分类号： C12Q1/002 , C12Q1/005 , Y10T436/144444
摘要： A conductive sensor and its use in a diagnostic assay are disclosed. The miniaturized conductive sensor, utilizing a conducting polymer, is used in a diagnostic device to determine the presence or concentration of a predetermined analyte in a liquid test sample, wherein the predetermined analyte, like glucose, is assayed by an oxidase interaction. The interaction between the oxidase and a small amount of the predetermined analyte in the test sample generates, either directly or indirectly, a dopant compound in a reaction zone of the conductive sensor. The dopant compound then migrates to the detection zone of the conductive sensor of the diagnostic device to oxidize the conducting polymer and convert the conducting polymer from an insulating form to a conducting form. The resulting increase in conductivity of the conducting polymer is measured, then the conductivity increase is correlated to the concentration of the predetermined analyte in the test sample.
摘要翻译： 公开了一种导电传感器及其在诊断测定中的应用。 使用导电聚合物的小型化导电传感器用于诊断装置中以确定液体测试样品中预定分析物的存在或浓度，其中通过氧化酶相互作用测定预定分析物（如葡萄糖）。 测试样品中氧化酶与少量预定分析物之间的相互作用直接或间接地产生导电传感器反应区中的掺杂剂化合物。 然后，掺杂剂化合物迁移到诊断装置的导电传感器的检测区域，以氧化导电聚合物并将导电聚合物从绝缘形式转换为导电形式。 测量导电聚合物导电率的增加，然后电导率增加与测试样品中预定分析物的浓度相关。
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公开(公告)号：US07125481B2
公开(公告)日：2006-10-24
申请号：US10864011
申请日：2004-06-09
IPC分类号： G01N27/327 , G01N27/333
CPC分类号： C12Q1/001 , G01N27/3274
摘要： An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.
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公开(公告)号：USRE44521E1
公开(公告)日：2013-10-08
申请号：US12257031
申请日：2008-10-23
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , G01N27/3274
摘要： An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.
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公开(公告)号：US06841052B2
公开(公告)日：2005-01-11
申请号：US09861437
申请日：2001-05-21
IPC分类号： C12Q1/00 , G01N33/487 , G01N27/327 , G01N27/333
CPC分类号： C12Q1/001 , G01N27/3274
摘要： An improved electrochemical sensor having a base bearing a working and counter electrode which provides a flow path for a fluid test sample. The working and counter electrodes are configured so that a major portion of the counter electrode is located downstream on the flow path from the working electrode with the exception of a small sub-element of the counter electrode which is in electrical communication with the primary portion of the counter electrode and located upstream of the working electrode. This configuration enables the sensor when the capillary space is incompletely filled with test fluid.
摘要翻译： 一种改进的电化学传感器，其具有承载工作和对电极的基座，其提供用于流体测试样品的流动路径。 工作电极和对电极被构造成使得相对电极的主要部分位于与工作电极相距的流动路径的下游，除了对电极的小子元件之外，该小子元件与主电极 对置电极并位于工作电极的上游。 当毛细管空间未完全填充测试流体时，该配置使得传感器成为可能。
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公开(公告)号：US06531040B2
公开(公告)日：2003-03-11
申请号：US09731943
申请日：2000-12-08
IPC分类号： G01N2726
CPC分类号： C12Q1/001 , G01N27/3274
摘要： Disclosed is an electrochemical sensor for detecting the concentration of an analyte such as glucose in a fluid test sample. The sensor involves a base as flow path for the fluid test sample having a working and counter electrode on its surface. The base is mated with a cover to form a capillary space to capture the fluid and the counter electrode has a sub-element located upstream in the flow path. When there is detected electrical communication only between the sub-element and the working electrode the meter, with which the sensor is in electrical communication senses that the capillary space has not completely filled with test fluid.
摘要翻译： 公开了一种用于检测流体测试样品中诸如葡萄糖的分析物浓度的电化学传感器。 该传感器涉及一个流动测试样品的流动路径，其底部具有在其表面上的工作和反电极。 基座与盖子配合以形成毛细管空间以捕获流体，并且对电极具有位于流动路径上游的子元件。 当仅在子元件和工作电极之间检测到电气通信时，与传感器电连通的仪表可以检测到毛细管空间未完全充满测试流体。
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公开(公告)号：US5856195A
公开(公告)日：1999-01-05
申请号：US740564
申请日：1996-10-30
IPC分类号： G01N27/26 , G01N27/416 , G01N33/487 , G01N33/49 , G01N33/48 , G01N21/00 , G01N33/50 , G01N35/00
CPC分类号： G01N33/48771 , Y10T436/10 , Y10T436/104998 , Y10T436/11 , Y10T436/110833 , Y10T436/112499 , Y10T436/114165 , Y10T436/115831
摘要： A method and apparatus are provided for calibrating a sensor for determination of analyte concentration. The meter includes a sensor for receiving a user sample to be measured and a processor for performing a predefined test sequence for measuring a predefined parameter value. A memory can be coupled to the processor for storing predefined parameter data values. A calibration code is associated with the sensor and read by the processor before the user sample to be measured is received. The calibration code is used in measuring the predefined parameter data value to compensate for different sensor characteristics.
摘要翻译： 提供了用于校准用于测定分析物浓度的传感器的方法和装置。 仪表包括用于接收待测量的用户样本的传感器和用于执行用于测量预定义参数值的预定义测试序列的处理器。 存储器可以耦合到处理器以存储预定义的参数数据值。 在接收到要测量的用户样本之前，校准代码与传感器相关联并由处理器读取。 校准代码用于测量预定义的参数数据值，以补偿不同的传感器特性。
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公开(公告)号：US08529742B2
公开(公告)日：2013-09-10
申请号：US12711806
申请日：2010-02-24
IPC分类号： G01N27/327
CPC分类号： G01N27/3272
摘要： An electrochemical sensor includes a dielectric substrate and a conductive layer formed on a surface of the substrate. The conductive layer includes a working electrode, an electrode lead and a connecting arm connecting the working electrode to the electrode lead. A dielectric layer is positioned over the conductive layer. The dielectric layer has an aperture exposing the working electrode and a portion of the connecting arm. The working electrode, electrode lead and connecting arm may be formed by laser ablation technique to provide precise working electrode sensor parameters.
摘要翻译： 电化学传感器包括介电基片和形成在基片表面上的导电层。 导电层包括工作电极，电极引线和将工作电极连接到电极引线的连接臂。 电介质层位于导电层上。 电介质层具有暴露工作电极和连接臂的一部分的孔。 工作电极，电极引线和连接臂可以通过激光烧蚀技术形成，以提供精确的工作电极传感器参数。
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公开(公告)号：US20110203926A1
公开(公告)日：2011-08-25
申请号：US12711806
申请日：2010-02-24
IPC分类号： G01N27/26
CPC分类号： G01N27/3272
摘要： An electrochemical sensor includes a dielectric substrate and a conductive layer formed on a surface of the substrate. The conductive layer includes a working electrode, an electrode lead and a connecting arm connecting the working electrode to the electrode lead. A dielectric layer is positioned over the conductive layer. The dielectric layer has an aperture exposing the working electrode and a portion of the connecting arm. The working electrode, electrode lead and connecting arm may be formed by laser ablation technique to provide precise working electrode sensor parameters.
摘要翻译： 电化学传感器包括介电基片和形成在基片表面上的导电层。 导电层包括工作电极，电极引线和将工作电极连接到电极引线的连接臂。 电介质层位于导电层上。 电介质层具有暴露工作电极和连接臂的一部分的孔。 工作电极，电极引线和连接臂可以通过激光烧蚀技术形成，以提供精确的工作电极传感器参数。
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公开(公告)号：US20090015273A1
公开(公告)日：2009-01-15
申请号：US12172329
申请日：2008-07-14
申请人： Paul Gossen , Jayant Angal , Matthew K. Musho , Joseph E. Yates
发明人： Paul Gossen , Jayant Angal , Matthew K. Musho , Joseph E. Yates
CPC分类号： G01N27/07 , G01N2001/028
摘要： A test system for taking a sample of a constituent on a surface utilizing a fluid source includes a transition region having a capillary layer for delivering a fluid from said fluid source, an extraction region having a collection material in contact with said surface, and a collection region having a sensor reservoir therein for collecting the fluid for analysis.
摘要翻译： 用于利用流体源在表面上取得表面上的成分样品的测试系统包括具有用于从所述流体源输送流体的毛细管层的过渡区域，具有与所述表面接触的收集材料的提取区域和收集 区域，其中具有用于收集用于分析的流体的传感器储存器。
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