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    Spring loaded docking mechanism
    1.
    发明授权
    Spring loaded docking mechanism 有权
    弹簧加载对接机制

    公开(公告)号：US08800075B2

    公开(公告)日：2014-08-12

    申请号：US13205201

    申请日：2011-08-08

    申请人： Jan Christopher van Leyen ,  Shoufeng Li

    发明人： Jan Christopher van Leyen ,  Shoufeng Li

    IPC分类号： E03D1/04

    CPC分类号： E03C1/0404 ,  E03C2001/0415

    摘要： An improved docking assembly for faucets having a pull-down sprayhead extendable from a spout. The docking assembly generally comprises a receptacle fitted into the spout which is formed with chamfered interior walls. A spring-loaded flexible collet is contained within the receptacle with a degree of sliding freedom for spring-biased travel along the chamfered interior walls of the receptacle, from a first position that allows generous radial expansion of the collet to a second position in which radial expansion is restricted. A quick-connect fitting attached to the pull-down sprayhead moves the collet into its first position allowing radial expansion of the collet. Removal of the quick-connect fitting moves the collet to its second position which restricts radial expansion, inhibiting said removal. Consequently, the pulldown sprayhead may be docked to the spout with considerably less insertion force than the opposite removal force needed to undock the pulldown sprayhead from the spout.

    摘要翻译： 一种用于水龙头的改进的对接组件，其具有可从喷口延伸的下拉喷头。 对接组件通常包括装配到喷口中的插座，其形成有倒角的内壁。 弹簧加载的弹性夹头容纳在容器内，具有一定程度的滑动自由度，用于沿着插座的倒角内壁的弹簧偏置行进，从允许夹头大幅度径向膨胀到第二位置的第一位置，其中径向 扩张受到限制 连接到下拉式喷头的快速连接配件将夹头移动到其第一位置，允许夹头径向膨胀。 快速连接配件的拆卸将夹头移动到其限制径向膨胀的第二位置，从而阻止所述拆卸。 因此，下拉式喷头可以以比相对于从喷口拆下下拉喷头所需的相反的移除力相对更小的插入力对接到喷口。

    SPRING LOADED DOCKING MECHANISM
    2.
    发明申请
    SPRING LOADED DOCKING MECHANISM 有权
    弹簧装载机构

    公开(公告)号：US20130037626A1

    公开(公告)日：2013-02-14

    申请号：US13205201

    申请日：2011-08-08

    申请人： Jan Christopher van Leyen ,  Shoufeng Li

    发明人： Jan Christopher van Leyen ,  Shoufeng Li

    IPC分类号： A62C33/00

    CPC分类号： E03C1/0404 ,  E03C2001/0415

    摘要： An improved docking assembly for faucets having a pull-down sprayhead extendable from a spout. The docking assembly generally comprises a receptacle fitted into the spout which is formed with chamfered interior walls. A spring-loaded flexible collet is contained within the receptacle with a degree of sliding freedom for spring-biased travel along the chamfered interior walls of the receptacle, from a first position that allows generous radial expansion of the collet to a second position in which radial expansion is restricted. A quick-connect fitting attached to the pull-down sprayhead moves the collet into its first position allowing radial expansion of the collet. Removal of the quick-connect fitting moves the collet to its second position which restricts radial expansion, inhibiting said removal. Consequently, the pulldown sprayhead may be docked to the spout with considerably less insertion force than the opposite removal force needed to undock the pulldown sprayhead from the spout.

    摘要翻译： 一种用于水龙头的改进的对接组件，其具有可从喷口延伸的下拉喷头。 对接组件通常包括装配到喷口中的插座，其形成有倒角的内壁。 弹簧加载的弹性夹头容纳在容器内，具有一定程度的滑动自由度，用于沿着插座的倒角内壁的弹簧偏置行进，从允许夹头大幅度径向膨胀到第二位置的第一位置，其中径向 扩张受到限制 连接到下拉式喷头的快速连接配件将夹头移动到其第一位置，允许夹头径向膨胀。 快速连接配件的拆卸将夹头移动到其限制径向膨胀的第二位置，从而阻止所述拆卸。 因此，下拉式喷头可以以比相对于从喷口拆下下拉喷头所需的相反的移除力相对更小的插入力对接到喷口。

    PHARMACEUTICAL COMPOSITIONS
    6.
    发明申请
    PHARMACEUTICAL COMPOSITIONS 审中-公开
    药物组合物

    公开(公告)号：US20130245061A1

    公开(公告)日：2013-09-19

    申请号：US13989250

    申请日：2011-12-01

    申请人： Yu Cao ,  Wolfgang Hackl ,  Ping Li ,  Shoufeng Li ,  Tahseen Mirza ,  Hartmut Zehender ,  Jiahao Zhu

    发明人： Yu Cao ,  Wolfgang Hackl ,  Ping Li ,  Shoufeng Li ,  Tahseen Mirza ,  Hartmut Zehender ,  Jiahao Zhu

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1694 ,  A61K31/00

    摘要： A pharmaceutical composition for the oral administration of a therapeutic compound of formula (I), comprising granules that comprise at least therapeutic compound of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt, or a hydrate or solvate thereof; at least one non-ionic surfactant that is Vitamin E-TPGS in an amount ranging from about 15 to about 80% by weight of the composition; and at least one a dissolution enhancing agent selected from polyethylene glycol, polyethylene oxide, and any combination of the foregoing; processes for making such pharmaceutical compositions; a kit comprising such pharmaceutical composition and the instructions for administration thereof; and related uses and methods of treatment.

    摘要翻译： 口服给药式（I）治疗性化合物的药物组合物，其包含至少包含治疗性式（I）化合物或其互变异构体或其药学上可接受的盐或其水合物或溶剂合物的颗粒剂; 至少一种非离子表面活性剂，其量为所述组合物的约15至约80重量％的量的维生素E-TPGS; 和至少一种选自聚乙二醇，聚环氧乙烷和前述的任何组合的溶解增强剂; 制备这种药物组合物的方法; 包含该药物组合物的试剂盒及其施用说明书; 及相关用途及治疗方法。

    Pharmaceutical Composition
    9.
    发明申请
    Pharmaceutical Composition 审中-公开
    药物组成

    公开(公告)号：US20080255048A1

    公开(公告)日：2008-10-16

    申请号：US12093383

    申请日：2006-11-16

    申请人： Moise Azria ,  Simon David Bateman ,  Anasuya Ashok Ghosh ,  Shoufeng Li ,  Alan Edward Royce

    发明人： Moise Azria ,  Simon David Bateman ,  Anasuya Ashok Ghosh ,  Shoufeng Li ,  Alan Edward Royce

    IPC分类号： A61K38/23 ,  A61K38/02 ,  A61P19/00

    CPC分类号： A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/198 ,  A61K38/23 ,  A61K38/29

    摘要： The present invention provides oral pharmaceutical compositions that enable the successful delivery of drugs in a pharmaceutically effective amount, particularly poly (amino acids) such as peptides, peptidomimetics and proteins, e.g. hormones to a subject via oral administration to accomplish the desired therapeutic effect. The oral pharmaceutical composition comprising a poly (amino acid) as the active ingredient, e.g. a peptide or protein, shows a rapid disintegration and/or dissolution such that the active ingredient is able to attain a therapeutic effect.

    摘要翻译： 本发明提供口服药物组合物，其能够以药学有效量成功递送药物，特别是聚（氨基酸），例如肽，肽模拟物和蛋白质，例如， 通过口服给予受试者的激素以实现期望的治疗效果。 包含聚（氨基酸）作为活性成分的口服药物组合物，例如， 肽或蛋白质显示快速崩解和/或溶解，使得活性成分能够获得治疗效果。