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公开(公告)号：US20120195909A1
公开(公告)日：2012-08-02
申请号：US13216751
申请日：2011-08-24
申请人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
发明人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
IPC分类号： A61K39/395 , C12N5/16 , C12N15/63 , A61P29/00 , C07K16/24 , C12N15/13 , A61P35/00 , A61P37/00 , C12P21/06 , G01N33/566
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
摘要翻译： 本发明涉及结合人APRIL的结合化合物。 更具体地，本发明提供了抗APRIL特异性抗体的组合物和使用这种抗体调节生物活性APRIL，特别是炎性疾病，抑制细胞增殖和癌症的方法。
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2.发明授权Antibodies against a proliferating inducing ligand (APRIL) and methods of use thereof 有权针对增殖诱导配体（APRIL）的抗体及其使用方法公开(公告)号：US09000128B2
公开(公告)日：2015-04-07
申请号：US13792339
申请日：2013-03-11
申请人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
发明人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , G01N33/53 , C07K16/28 , C07K16/24 , G01N33/68 , A61K39/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
摘要翻译： 本发明涉及结合人APRIL的结合化合物。 更具体地，本发明提供了抗APRIL特异性抗体的组合物和使用这种抗体调节生物活性APRIL，特别是炎性疾病，抑制细胞增殖和癌症的方法。
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3.发明授权Antibodies against a proliferating inducing ligand (APRIL) and methods of use thereof 有权针对增殖诱导配体（APRIL）的抗体及其使用方法公开(公告)号：US08895705B2
公开(公告)日：2014-11-25
申请号：US13216751
申请日：2011-08-24
申请人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
发明人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
IPC分类号： C07K16/00 , C12P21/08 , G01N33/53 , C07K1/00 , C07K14/00 , C07K17/00 , C07K16/24 , C07K16/28 , G01N33/68 , A61K39/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
摘要翻译： 本发明涉及结合人APRIL的结合化合物。 更具体地，本发明提供了抗APRIL特异性抗体的组合物和使用这种抗体调节生物活性APRIL，特别是炎性疾病，抑制细胞增殖和癌症的方法。
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公开(公告)号：US20130302353A1
公开(公告)日：2013-11-14
申请号：US13792406
申请日：2013-03-11
申请人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
发明人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
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公开(公告)号：US20130295103A1
公开(公告)日：2013-11-07
申请号：US13792380
申请日：2013-03-11
申请人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
发明人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
摘要翻译： 本发明涉及结合人APRIL的结合化合物。 更具体地，本发明提供了抗APRIL特异性抗体的组合物和使用这种抗体调节生物活性APRIL，特别是炎性疾病，抑制细胞增殖和癌症的方法。
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公开(公告)号：US20130273064A1
公开(公告)日：2013-10-17
申请号：US13792339
申请日：2013-03-11
申请人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
发明人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
IPC分类号： C07K16/24
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
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公开(公告)号：US20140112942A1
公开(公告)日：2014-04-24
申请号：US13792425
申请日：2013-03-11
申请人： Hans Van Eenennaam , Winfried Robert Mulder , Jannetje Geertruida Borst , Aartje Maria Elizabeth Veraar , Paul Maria Frederikus Vink
发明人： Hans Van Eenennaam , Winfried Robert Mulder , Jannetje Geertruida Borst , Aartje Maria Elizabeth Veraar , Paul Maria Frederikus Vink
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395
CPC分类号： C07K16/2878 , A61K39/3955 , A61K45/06 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The invention relates to a binding compound, which binds the same epitope of human CD27 as monoclonal antibody hCD27.15, produced by hybridoma hCD27.15 which was deposited with the ATCC in on Jun. 2, 2010 under number PTA-11008. In particular the invention relates to such a binding compound of claim 1 which may comprise: an antibody heavy chain variable region which may comprise at least one CDR selected from the group consisting of SEQ ID NOs: 5, 6 and 7, or a variant of any of said sequences; and/or an antibody light chain variable region which may comprise at least one CDR selected from the group consisting of SEQ ID NOs: 8, 9 and 10, or a variant of any of said sequences.
摘要翻译： 本发明涉及一种结合化合物，其结合人单克隆抗体hCD27.15的相同抗原决定簇，该抗体是由编号为PTA-11008的2010年6月2日保藏于ATCC的杂交瘤hCD27.15产生的。 特别地，本发明涉及权利要求1的这种结合化合物，其可以包含：抗体重链可变区，其可以包含选自SEQ ID NO：5,6和7中的至少一个CDR，或者 任何所述序列; 和/或抗体轻链可变区，其可以包含选自SEQ ID NO：8,9和10的至少一个CDR，或任何所述序列的变体。
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公开(公告)号：US20100266617A1
公开(公告)日：2010-10-21
申请号：US12663950
申请日：2008-06-13
CPC分类号： C07K16/2803 , C07K16/2818 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/57488 , G01N33/6869 , G01N2333/55 , G01N2800/52
摘要： Antibodies which block the binding of human Programmed Death Receptor 1(hPD-1) to its ligands (hPD-L1 or hPD-L2) and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune response through the PD-I pathway is also disclosed.
摘要翻译： 公开了阻断人程序死亡受体1（hPD-1）与其配体（hPD-L1或hPD-L2）及其可变区序列的结合的抗体。 还公开了通过PD-1途径增加免疫应答的活性（或降低调节）的方法。
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