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1.发明申请公开(公告)号：US20180161427A1
公开(公告)日：2018-06-14
申请号：US15577377
申请日：2016-05-26
申请人： Ying YU , Elliot Keith CHARTASH , Svetlana SADEKOVA , Uyen Truong PHAN , Robert A. KASTELEIN , Robert L. COFFMAN , Cristiana GUIDUCCI , Robert S. JANSSEN , MERCK SHARP & DOHME CORP. , DYNAVAX TECHNOLOGIES CORPORATION
发明人： Ying YU , Elliot Keith CHARTASH , Svetlana SADEKOVA , Uyen Truong PHAN , Robert A. KASTELEIN , Robert L. COFFMAN , Cristiana GUIDUCCI , Robert S. JANSSEN
IPC分类号： A61K39/395 , A61K31/7125 , A61P35/00
CPC分类号： A61K39/3955 , A61K31/7125 , A61K2039/505 , A61K2039/54 , A61K2039/545 , A61K2039/55561 , A61P35/00 , C07K16/244
摘要： The present disclosure describes combination therapies comprising an anti-IL-10 antibody or antigen-binding fragment thereof and a CpG-C type oligonucleotide, and the use of the combination therapies for the treatment of cancer.
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公开(公告)号：US20120195909A1
公开(公告)日：2012-08-02
申请号：US13216751
申请日：2011-08-24
申请人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
发明人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
IPC分类号： A61K39/395 , C12N5/16 , C12N15/63 , A61P29/00 , C07K16/24 , C12N15/13 , A61P35/00 , A61P37/00 , C12P21/06 , G01N33/566
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
摘要翻译： 本发明涉及结合人APRIL的结合化合物。 更具体地，本发明提供了抗APRIL特异性抗体的组合物和使用这种抗体调节生物活性APRIL，特别是炎性疾病，抑制细胞增殖和癌症的方法。
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公开(公告)号：US20130302353A1
公开(公告)日：2013-11-14
申请号：US13792406
申请日：2013-03-11
申请人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
发明人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
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公开(公告)号：US20130295103A1
公开(公告)日：2013-11-07
申请号：US13792380
申请日：2013-03-11
申请人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
发明人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
摘要翻译： 本发明涉及结合人APRIL的结合化合物。 更具体地，本发明提供了抗APRIL特异性抗体的组合物和使用这种抗体调节生物活性APRIL，特别是炎性疾病，抑制细胞增殖和癌症的方法。
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公开(公告)号：US20130273064A1
公开(公告)日：2013-10-17
申请号：US13792339
申请日：2013-03-11
申请人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
发明人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
IPC分类号： C07K16/24
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
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6.发明授权Antibodies against a proliferating inducing ligand (APRIL) and methods of use thereof 有权针对增殖诱导配体（APRIL）的抗体及其使用方法公开(公告)号：US09000128B2
公开(公告)日：2015-04-07
申请号：US13792339
申请日：2013-03-11
申请人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
发明人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , G01N33/53 , C07K16/28 , C07K16/24 , G01N33/68 , A61K39/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
摘要翻译： 本发明涉及结合人APRIL的结合化合物。 更具体地，本发明提供了抗APRIL特异性抗体的组合物和使用这种抗体调节生物活性APRIL，特别是炎性疾病，抑制细胞增殖和癌症的方法。
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7.发明授权Antibodies against a proliferating inducing ligand (APRIL) and methods of use thereof 有权针对增殖诱导配体（APRIL）的抗体及其使用方法公开(公告)号：US08895705B2
公开(公告)日：2014-11-25
申请号：US13216751
申请日：2011-08-24
申请人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
发明人： Jan Paul Medema , Hans Van Eenennaam , Marco Guadagnoli , Fiona Clare Kimberley , Uyen Truong Phan
IPC分类号： C07K16/00 , C12P21/08 , G01N33/53 , C07K1/00 , C07K14/00 , C07K17/00 , C07K16/24 , C07K16/28 , G01N33/68 , A61K39/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/241 , C07K16/2875 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , G01N33/6863
摘要： The present invention relates to a binding compound which binds to human APRIL. More specifically the invention provides, compositions of anti-APRIL specific antibodies and methods to use such antibodies in modulating the biological activity APRIL, particularly in inflammatory diseases, inhibition of cell proliferation and cancer.
摘要翻译： 本发明涉及结合人APRIL的结合化合物。 更具体地，本发明提供了抗APRIL特异性抗体的组合物和使用这种抗体调节生物活性APRIL，特别是炎性疾病，抑制细胞增殖和癌症的方法。
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公开(公告)号：US20180169229A1
公开(公告)日：2018-06-21
申请号：US15577369
申请日：2016-05-26
申请人： Ying YU , Andrew Evan DENKER , Svetlana SADEKOVA , Uyen truong PHAN , Robert A. KASTELEIN , David Ross KAUFMAN , Robert L. COFFMAN , Cristiana GUIDUCCI , Robert S. JANSSEN , MERCK SHARP & DOHME CORP. , DYNAVAX TECHNOLOGIES CORPORATION
发明人： Ying YU , Andrew Evan DENKER , Svetlana SADEKOVA , Uyen Truong PHAN , Robert A. KASTELEIN , David Ross KAUFMAN , Robert L. COFFMAN , Cristiana GUIDUCCI , Robert S. JANSSEN
IPC分类号： A61K39/395 , A61K31/7115 , A61K45/06 , C07K14/435 , A61P35/00
摘要： The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a Toll-like receptor 9 (TLR9) agonist that is a CpG-C type oligonucleotide, and the use of the combination therapies for the treatment of cancer.
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