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    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
    2.
    发明申请
    Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power 失效

    公开(公告)号：US20060184092A1

    公开(公告)日：2006-08-17

    申请号：US11055930

    申请日：2005-02-11

    申请人： Liliana Atanasoska ,  Thomas Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    发明人： Liliana Atanasoska ,  Thomas Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

    IPC分类号： A61N1/30

    CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

    摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

    Laser shock peening of medical devices
    10.
    发明申请
    Laser shock peening of medical devices 失效
    医疗器械的激光冲击硬化

    公开(公告)号：US20050182478A1

    公开(公告)日：2005-08-18

    申请号：US10778841

    申请日：2004-02-13

    申请人： Thomas Holman ,  Jan Weber

    发明人： Thomas Holman ,  Jan Weber

    IPC分类号： A61F2/00 ,  A61F2/06 ,  A61F2/90 ,  C21D10/00

    CPC分类号： C21D10/005 ,  A61F2/91 ,  A61F2250/0068

    摘要： A laser shock peening process for producing one or more compressive residual stress regions in a medical device is disclosed. A high-energy laser apparatus can be utilized to direct an intense laser beam through a confining medium and onto the target surface of a workpiece. An absorption overlay disposed on the target surface of the workpiece absorbs the laser beam, inducing a pressure shock wave that forms a compressive residual stress region deep within the workpiece. Medical devices such as stents and guidewires having one or more of these compressive residual stress regions are also disclosed.

    摘要翻译： 公开了一种用于在医疗装置中产生一个或多个压缩残余应力区域的激光冲击硬化方法。 可以使用高能激光装置将强激光束引导通过约束介质和工件的目标表面。 设置在工件的目标表面上的吸收层吸收激光束，引起在工件内部形成压缩残余应力区域的压力冲击波。 还公开了具有这些压缩残余应力区域中的一个或多个的支架和导线的医疗装置。