公开(公告)号：US20080050462A1

公开(公告)日：2008-02-28

申请号：US11849913

申请日：2007-09-04

申请人： Thomas Holman ,  Nam Hoang ,  Jeffrey Lindquist ,  Richard Dunn ,  Scott Schewe ,  Kevin Silberg ,  David Parsons ,  Ken Zhang ,  Afsar Ali

发明人： Thomas Holman ,  Nam Hoang ,  Jeffrey Lindquist ,  Richard Dunn ,  Scott Schewe ,  Kevin Silberg ,  David Parsons ,  Ken Zhang ,  Afsar Ali

IPC分类号： B29C45/78

CPC分类号： A61M25/1029 ,  B29C49/6445 ,  B29L2031/7542

摘要： Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.

摘要翻译： 医疗装置气囊由管状型坯通过工艺或装置形成，该方法或装置在径向膨胀开始的型坯上建立受控的位置（起始区）。 在起始区域内的起始是通过将该位置的型坯加热到比型坯的其余部分高的至少一部分吹制时间的温度来实现的。 提供了各种装置配置，其中一些允许容易重新配置启动区域的大小和位置。 气球也可以改装，后吹，使用加热装置和方法描述。

公开(公告)号：US20050146085A1

公开(公告)日：2005-07-07

申请号：US10753043

申请日：2004-01-07

申请人： Thomas Holman ,  Nam Hoang ,  Jeffrey Lindquist ,  Richard Dunn ,  Scott Schewe ,  Kevin Silberg ,  David Parsons ,  Ken Xiao Zhang ,  Afsar Ali

发明人： Thomas Holman ,  Nam Hoang ,  Jeffrey Lindquist ,  Richard Dunn ,  Scott Schewe ,  Kevin Silberg ,  David Parsons ,  Ken Xiao Zhang ,  Afsar Ali

IPC分类号： A61M25/00 ,  B29C49/64

CPC分类号： A61M25/1029 ,  B29C49/6445 ,  B29L2031/7542

摘要： Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.

摘要翻译： 医疗装置气囊由管状型坯通过工艺或装置形成，该方法或装置在径向膨胀开始的型坯上建立受控的位置（起始区）。 在起始区域内的起始是通过将该位置的型坯加热到比型坯的其余部分高的至少一部分吹制时间的温度来实现的。 提供了各种装置配置，其中一些允许容易重新配置启动区域的大小和位置。 气球也可以改装，后吹，使用加热装置和方法描述。

公开(公告)号：US07708928B2

公开(公告)日：2010-05-04

申请号：US12336073

申请日：2008-12-16

申请人： Thomas Holman ,  Nam H. Hoang ,  Jeffrey S. Lindquist ,  Richard Dunn ,  Scott Schewe ,  Kevin Silberg ,  David Parsons ,  Ken Xiao Kang Zhang ,  Afsar Ali

发明人： Thomas Holman ,  Nam H. Hoang ,  Jeffrey S. Lindquist ,  Richard Dunn ,  Scott Schewe ,  Kevin Silberg ,  David Parsons ,  Ken Xiao Kang Zhang ,  Afsar Ali

IPC分类号： B29C49/64

CPC分类号： A61M25/1029 ,  B29C49/6445 ,  B29L2031/7542

摘要： Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.

摘要翻译： 医疗装置气囊由管状型坯通过工艺或装置形成，该方法或装置在径向膨胀开始的型坯上建立受控的位置（起始区）。 在起始区域内的起始是通过将该位置的型坯加热到比型坯的其余部分高的至少一部分吹制时间的温度来实现的。 提供了各种装置配置，其中一些允许容易重新配置启动区域的大小和位置。 气球也可以改装，后吹，使用加热装置和方法描述。

公开(公告)号：US20060182873A1

公开(公告)日：2006-08-17

申请号：US11060151

申请日：2005-02-17

申请人： Leo Klisch ,  Jan Weber ,  Thomas Holman ,  Scott Schewe ,  Afsar Ali ,  Richard Noddin ,  James Shippy ,  Karl Jagger ,  Jan Seppala

发明人： Leo Klisch ,  Jan Weber ,  Thomas Holman ,  Scott Schewe ,  Afsar Ali ,  Richard Noddin ,  James Shippy ,  Karl Jagger ,  Jan Seppala

IPC分类号： A61L33/00

CPC分类号： A61B17/320725 ,  A61B2017/22061 ,  A61M25/10 ,  A61M25/1029 ,  A61M25/1038 ,  A61M2025/1031 ,  A61M2025/1075 ,  A61M2025/1086 ,  A61M2025/1088

摘要： Medical devices, for example, those that have balloons, and methods of making the devices are described. In some embodiments, a method includes providing a medical balloon having a first cone portion and a body portion, and removing material from an outer surface the body portion of the balloon such that the balloon includes a first region and a second region, the first region being recessed relative to the second region.

摘要翻译： 描述了医疗设备，例如具有气球的设备，以及制造设备的方法。 在一些实施例中，一种方法包括提供具有第一锥形部分和主体部分的医疗气囊，以及从球囊的主体部分的外表面移除材料，使得球囊包括第一区域和第二区域，第一区域 相对于第二区域凹进。

公开(公告)号：US20060135909A1

公开(公告)日：2006-06-22

申请号：US11020540

申请日：2004-12-22

申请人： Thomas Holman ,  Afsar Ali

发明人： Thomas Holman ,  Afsar Ali

IPC分类号： A61M29/00

CPC分类号： A61M25/1034 ,  A61M25/10 ,  A61M2025/1093 ,  Y10T156/10

摘要： A catheter assembly comprises at least one catheter shaft and a balloon. The catheter shaft comprises a substantially cylindrical portion and at least one tapered portion. The tapered portion forms an angle with the cylindrical portion of about 1 degree to about 25 degrees. At least one of the waists of the balloon is sealingly engaged to the tapered portion.

摘要翻译： 导管组件包括至少一个导管轴和气球。 导管轴包括基本上圆柱形的部分和至少一个锥形部分。 锥形部分与圆柱形部分形成约1度至约25度的角度。 球囊的至少一个腰部密封地接合到锥形部分。

公开(公告)号：US20060289112A1

公开(公告)日：2006-12-28

申请号：US11166027

申请日：2005-06-23

申请人： Thomas Holman ,  Afsar Ali ,  Stacie Depner

发明人： Thomas Holman ,  Afsar Ali ,  Stacie Depner

IPC分类号： B32B37/00

CPC分类号： B29C65/04 ,  A61M25/005 ,  A61M25/1036 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/1056 ,  B29C65/14 ,  B29C65/1406 ,  B29C65/1409 ,  B29C65/1412 ,  B29C65/1496 ,  B29C65/1606 ,  B29C65/1612 ,  B29C65/1619 ,  B29C65/1629 ,  B29C65/1632 ,  B29C65/1674 ,  B29C65/1696 ,  B29C65/7802 ,  B29C66/003 ,  B29C66/5227 ,  B29C66/63 ,  B29C66/71 ,  B29C66/73921 ,  B29C66/73941 ,  B29C66/81267 ,  B29C66/81423 ,  B29C66/81425 ,  B29C66/81431 ,  B29C66/83221 ,  B29K2709/02 ,  B29L2031/753 ,  B29L2031/7542 ,  B29K2083/00 ,  B29K2077/00 ,  B29K2075/02 ,  B29K2075/00 ,  B29K2071/00 ,  B29K2067/00 ,  B29K2063/00 ,  B29K2033/08 ,  B29K2027/12 ,  B29K2023/16 ,  B29K2023/00 ,  B29K2049/00 ,  B29K2033/12 ,  B29K2021/00

摘要： Methods of making medical devices are disclosed. In some embodiments, a method for welding together two components is described. The two components are non-coaxial and contact one another. A fixture holds the two components in a desired configuration. Electromagnetic radiation is directed at an area where the two components are in contact. The radiation causes the two portions to fuse together. The fixture has an open area or a transmissive material in the path of the electromagnetic radiation so that at least a portion of the radiation impinged up on the two components.

摘要翻译： 披露了制造医疗器械的方法。 在一些实施例中，描述了用于将两个部件焊接在一起的方法。 两个部件是非同轴的并且彼此接触。 夹具将两个部件保持在所需的配置中。 电磁辐射指向两个部件接触的区域。 辐射使两部分熔合在一起。 固定装置在电磁辐射的路径中具有开放区域或透射材料，使得至少一部分辐射照射在两个部件上。

公开(公告)号：US20060282156A1

公开(公告)日：2006-12-14

申请号：US11152555

申请日：2005-06-14

申请人： Jan Weber ,  Thomas Holman ,  Scott Schewe

发明人： Jan Weber ,  Thomas Holman ,  Scott Schewe

IPC分类号： A61F2/06

CPC分类号： A61F2/95 ,  A61F2/91 ,  A61F2/958 ,  A61F2210/0033 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2250/0018 ,  A61F2250/0068 ,  A61M25/09 ,  A61M25/1006 ,  A61M25/10186 ,  A61M2025/1015 ,  A61M2025/105 ,  A61M2025/1056 ,  A61M2025/1068 ,  A61M2025/1086 ,  A61M2025/1093

摘要： A medical system including an elongate member and an elongate element associated with the elongate member so that a shape of the elongate member can be altered upon applying energy to the element.

摘要翻译： 一种医疗系统，包括细长构件和与细长构件相关联的细长元件，使得在向元件施加能量时可以改变细长构件的形状。

公开(公告)号：US20060184092A1

公开(公告)日：2006-08-17

申请号：US11055930

申请日：2005-02-11

申请人： Liliana Atanasoska ,  Thomas Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

发明人： Liliana Atanasoska ,  Thomas Holman ,  Jan Weber ,  Robert Warner ,  Scott Schewe

IPC分类号： A61N1/30

CPC分类号： A61N1/325 ,  A61N1/05 ,  A61N1/306 ,  A61N1/327

摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.

公开(公告)号：US20060129179A1

公开(公告)日：2006-06-15

申请号：US11010810

申请日：2004-12-13

申请人： Jan Weber ,  Scott Schewe ,  Thomas Holman

发明人： Jan Weber ,  Scott Schewe ,  Thomas Holman

IPC分类号： A61M29/00

CPC分类号： A61M25/1029 ,  A61M25/0009 ,  A61M25/0045 ,  A61M25/1036 ,  A61M25/104 ,  A61M2025/1075 ,  A61M2025/1086

摘要： Medical devices formed using a sacrificial structure, and processes of forming the devices therefrom.

摘要翻译： 使用牺牲结构形成的医疗器械，以及由其形成器件的工艺。

公开(公告)号：US20060079836A1

公开(公告)日：2006-04-13

申请号：US10963272

申请日：2004-10-12

申请人： Thomas Holman ,  Jan Weber ,  Scott Schewe

发明人： Thomas Holman ,  Jan Weber ,  Scott Schewe

IPC分类号： A61M29/00

CPC分类号： A61M25/1029 ,  A61M25/10 ,  A61M25/1002 ,  A61M25/1034 ,  A61M25/1038 ,  A61M2025/0058 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1084

摘要： The present invention generally relates to the field of intravascular medical devices, and more specifically to the field of balloon catheters and other similar diagnostic or therapeutic catheters within the body for treatment and diagnosis of diseases. In particular, the present invention relates to reinforced balloon catheters and drug-eluting balloon catheters and corresponding methods for producing same.