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公开(公告)号：US20110270073A1
公开(公告)日：2011-11-03
申请号：US12769967
申请日：2010-04-29
申请人： Jan-Henrik Ardenkjaer-Larsen , Jonathan Alan Murray , Fraser John Laing Robb , Ralph Eugene Hurd , Victor Taracila
发明人： Jan-Henrik Ardenkjaer-Larsen , Jonathan Alan Murray , Fraser John Laing Robb , Ralph Eugene Hurd , Victor Taracila
IPC分类号： A61B5/055
CPC分类号： G01R33/60 , A61B5/055 , A61B5/14542
摘要： An electron paramagnetic resonance imaging (EPRI) system includes a resistive magnet driven by a power supply such as a power supply module to generate radio frequency signals in a substantially coherent polyphase perfect sequence scheme. The EPRI system further includes image acquisition and processing electronics configured to generate, acquire, quantify and map pO2 information associated with a free radical agent in vivo and having a resonance line width that is sensitive to oxygen and in response to the radio frequency signals without imparting harmful heating effects to a corresponding human or animal body.
摘要翻译： 电子顺磁共振成像（EPRI）系统包括由诸如电源模块的电源驱动的电阻磁体，以产生基本上相干的多相完美序列方案中的射频信号。 EPRI系统还包括图像采集和处理电子器件，其被配置为在体内产生，获取，量化和映射与自由基相关的pO2信息，并且具有对氧敏感的谐振线宽度并且响应于射频信号而不赋予 对相应的人体或动物体有害的加热效果。
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2.发明申请公开(公告)号：US20130154637A1
公开(公告)日：2013-06-20
申请号：US13330451
申请日：2011-12-19
IPC分类号： G01R33/46
CPC分类号： A61B5/055 , A61B5/14539 , G01R33/4608 , G01R33/4804 , G01R33/485
摘要： The use of selective RF excitation is discussed. A spectrally selective, large tip angle RF pulse is used to detect a weak signal from a first chemical species. A non-selective, small tip angle pulse is used in measuring a signal from a second chemical species in exchange with the first chemical species. The acquired resonance data provides maybe used to measure the ratio of the spectrally distinct species in exchange.
摘要翻译： 讨论了选择性RF激励的使用。 使用光谱选择性大的尖角RF脉冲来检测来自第一化学物质的弱信号。 非选择性小尖角脉冲用于测量来自第二化学物质的信号以与第一化学物质交换。 获得的共振数据可用于测量光谱不同物种的交换比例。
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3.发明申请METHOD OF DETERMINING ALANINE TRANSAMINASE (ALT) ACTIVITY BY 13C-MR DETECTION USING HYPERPOLARISED 13C-PYRUVATE 审中-公开通过13C-MR检测利用13C-PYRUVATE进行检测的方法确定丙氨酰胺转移酶（ALT）活性公开(公告)号：US20110038802A1
公开(公告)日：2011-02-17
申请号：US12989795
申请日：2009-04-30
申请人： Zhong-Min Hu , Ralph Eugene Hurd , John Kurhanewicz , Sarah Jane Nelson , Daniel Blackburn Vigneron
发明人： Zhong-Min Hu , Ralph Eugene Hurd , John Kurhanewicz , Sarah Jane Nelson , Daniel Blackburn Vigneron
CPC分类号： A61K49/10 , C12Q1/52 , G01N2333/91188 , G01N2800/085
摘要： The invention relates to a method of determination of alanine transaminase (ALT) activity by 13C-MR detection using an imaging medium which comprises hyperpolarised 13C-pyruvate.
摘要翻译： 本发明涉及使用包含超极化13 C-丙酮酸的成像介质通过13C-MR检测测定丙氨酸转氨酶（ALT）活性的方法。
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4.发明授权公开(公告)号：US08933697B2
公开(公告)日：2015-01-13
申请号：US13330451
申请日：2011-12-19
IPC分类号： G01V3/00
CPC分类号： A61B5/055 , A61B5/14539 , G01R33/4608 , G01R33/4804 , G01R33/485
摘要： The use of selective RF excitation is discussed. A spectrally selective, large tip angle RF pulse is used to detect a weak signal from a first chemical species. A non-selective, small tip angle pulse is used in measuring a signal from a second chemical species in exchange with the first chemical species. The acquired resonance data provides maybe used to measure the ratio of the spectrally distinct species in exchange.
摘要翻译： 讨论了选择性RF激励的使用。 使用光谱选择性大的尖角RF脉冲来检测来自第一化学物质的弱信号。 非选择性小尖角脉冲用于测量来自第二化学物质的信号以与第一化学物质交换。 获得的共振数据可用于测量光谱不同物种的交换比例。
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5.发明申请FAST METABOLIC IMAGING OF SYSTEMS WITH SPARSE SPECTRA USING SPIRAL CSI 有权使用螺旋CSI的SPARSE SPECTRA的系统的快速代谢成像公开(公告)号：US20080057587A1
公开(公告)日：2008-03-06
申请号：US11469801
申请日：2006-09-01
申请人： Dirk Mayer , Yakir Levin , Daniel Spielman , Ralph Eugene Hurd
发明人： Dirk Mayer , Yakir Levin , Daniel Spielman , Ralph Eugene Hurd
IPC分类号： G01N33/00
CPC分类号： G01R33/485 , G01R33/5601 , Y10T436/24
摘要： A method of imaging the individual components of systems with sparse spectra using magnetic resonance imaging including the steps of a) exciting nuclei of labeled components using a MRI pulse sequence, b) selecting a proper spectral window to avoid/minimize signal overlap of aliased frequency components. In step a) preferably a spiral chemical shift imaging (spCSI) sequence is employed. In a preferred embodiment, hyperpolarized nuclei of 13C are used for labeling in a pyruvate substrate with metabolites of lacatate, alanine, and bicarbonate.
摘要翻译： 使用磁共振成像对具有稀疏光谱的系统的各个部件成像的方法，包括以下步骤：a）使用MRI脉冲序列激励标记分量的核; b）选择适当的光谱窗口以避免/最小化混叠频率分量的信号重叠 。 在步骤a）中优选使用螺旋化学位移成像（spCSI）序列。 在优选的实施方案中，13 C的超极化核用于在丙酮酸底物中用lacatate，丙氨酸和碳酸氢盐的代谢物进行标记。
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6.发明授权公开(公告)号：US07709266B2
公开(公告)日：2010-05-04
申请号：US11469801
申请日：2006-09-01
申请人： Dirk Mayer , Yakir Levin , Daniel Spielman , Ralph Eugene Hurd
发明人： Dirk Mayer , Yakir Levin , Daniel Spielman , Ralph Eugene Hurd
IPC分类号： G01N24/00
CPC分类号： G01R33/485 , G01R33/5601 , Y10T436/24
摘要： A method of imaging the individual components of systems with sparse spectra using magnetic resonance imaging including the steps of a) exciting nuclei of labeled components using a MRI pulse sequence, b) selecting a proper spectral window to avoid/minimize signal overlap of aliased frequency components. In step a) preferably a spiral chemical shift imaging (spCSI) sequence is employed. In a preferred embodiment, hyperpolarized nuclei of 13C are used for labeling in a pyruvate substrate with metabolites of lacatate, alanine, and bicarbonate.
摘要翻译： 使用磁共振成像对具有稀疏光谱的系统的各个部件成像的方法，包括以下步骤：a）使用MRI脉冲序列激励标记分量的核; b）选择适当的光谱窗口以避免/最小化混叠频率分量的信号重叠 。 在步骤a）中优选使用螺旋化学位移成像（spCSI）序列。 在优选的实施方案中，13C的超极化核用于在丙酮酸底物中用lacatate，丙氨酸和碳酸氢盐的代谢物进行标记。
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7.发明授权Interleaved MR spectroscopy and imaging with dynamically changing acquisition parameters 失效具有动态变化的采集参数的交错MR光谱和成像
公开(公告)号：US5657757A
公开(公告)日：1997-08-19
申请号：US516265
申请日：1995-08-17
IPC分类号： G01N24/00 , A61B5/055 , G01R33/483 , G01R33/54 , G01R33/20
CPC分类号： G01R33/4828 , G01R33/483
摘要： An MRS or MRI scan is performed by interleaving pulse sequences which acquire MR spectra or images from different locations in a subject. Parameters for the pulse sequence used to acquire MR data at each location are dynamically changed during the scan to optimize the MR measurements.
摘要翻译： MRS或MRI扫描通过交织从受试者的不同位置获取MR谱或图像的脉冲序列来执行。 用于在每个位置获取MR数据的脉冲序列的参数在扫描期间动态地改变，以优化MR测量。
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8.发明授权Methods and systems for detection and monitoring of neurodegenerative diseases using magnetic resonance spectroscopy 有权使用磁共振光谱法检测和监测神经变性疾病的方法和系统公开(公告)号：US07742800B2
公开(公告)日：2010-06-22
申请号：US11072831
申请日：2005-03-04
IPC分类号： A61B5/05
CPC分类号： G01R33/465 , A61B5/055 , A61B5/4088 , G01N33/6893 , G01N2800/28 , G01N2800/2821 , Y10T436/24
摘要： A method for increasing sensitivity and/or specificity of a magnetic resonance spectroscopy imaging technique for detecting a neurodegenerative disease is provided. The method includes acquiring magnetic resonance spectroscopy data from the brain of a subject, while suppressing certain metabolites in the spectrum via a data acquisition protocol, to improve quantification accuracy for the remaining metabolites, and quantifying a metabolite concentration or a metabolite concentration ratio from the spectral data as an indicator of the neurodegenerative disease.
摘要翻译： 提供了用于增加用于检测神经变性疾病的磁共振波谱成像技术的灵敏度和/或特异性的方法。 该方法包括从受试者脑中获取磁共振光谱数据，同时通过数据采集方案抑制光谱中的某些代谢物，以提高剩余代谢物的定量准确度，并从光谱中量化代谢物浓度或代谢物浓度比 数据作为神经变性疾病的指标。
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公开(公告)号：US20080146914A1
公开(公告)日：2008-06-19
申请号：US11612727
申请日：2006-12-19
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/0035 , A61B6/037 , A61B6/4417 , A61B6/5247
摘要： A method for imaging cancer using a combined PET-MRI system takes advantage of the performance characteristics for both PET and MRI in the context of cancer imaging. MRI is used to assess a large area of the body with high sensitivity for cancer and PET is then used in localized areas of concern to provide physiological information. Optionally, MRI may also then be used to re-scan the localized areas of concern with high spatial resolution and additional tissue contrasts to provide anatomical information and soft tissue contrast to supplement the PET information. The use of a combined PET-MRI system ensures that the imaging data from both modalities is accurately referenced to the same locations in the body.
摘要翻译： 使用组合PET-MRI系统对癌症进行成像的方法在癌症成像的背景下利用PET和MRI两者的性能特征。 MRI用于对癌症的高灵敏度的大面积身体进行评估，然后将PET用于关注的局部区域以提供生理信息。 可选地，MRI还可用于重新扫描具有高空间分辨率和附加组织对比度的局部区域，以提供解剖信息和软组织对比度来补充PET信息。 使用组合的PET-MRI系统确保来自两种模式的成像数据准确地参考身体中相同的位置。
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